8.592 - HST.452J (Spring
2022)
Statistical Physics
in Biology
Lecture 23
(Please note that lecture is being recorded)
Adaptive Immune System
T cells & thymic selection
- Development of the T cell repertoire in the thymus
- Basic biology of thymic development
- The effect of thymic selection on the specificity of T cells for pathogenic peptides
- Model of thymic selection effects
- Extreme value statistic
- Experimental tests of the model
- Quorum sensing
- Enabling the T cell repertoire to be relatively self tolerant and pathogen sensitive.
(Chakraborty Notes and Associated figures)
B cells & affinity maturation
Antibody maturation occurs takes place in Germinal Centers formed in lymph nodes:
Computational Model:
(Chakraborty Notes and Associated figures)
8.592 lecture- last update 4/10/22
by M. Kardar