8.592 - HST.452J (Spring 2022)

Statistical Physics in Biology

Lecture 23

(Please note that lecture is being recorded)


Adaptive Immune System

T cells & thymic selection

  1. Development of the T cell repertoire in the thymus
  2. Model of thymic selection effects
  3. Quorum sensing

(Chakraborty Notes and Associated figures)

B cells & affinity maturation

Antibody maturation occurs takes place in Germinal Centers formed in lymph nodes:

Computational Model:

 
(Chakraborty Notes and Associated figures)


8.592  lecture- last update 4/10/22 by M. Kardar