2010-2015

  1. Ciaccio M.F., J.P. Wagner, C.-P. Chuu, D.A. Lauffenburger, and R.B. Jones, “Systems Analysis of EGF Receptor Signaling Dynamics with Micro-Western Arrays”, Nature Methods 7: 148-155 (2010).
  2. Kreeger, P.K., Y. Wang, K.M. Haigis, and D.A. Lauffenburger, “Integration of Multiple Signaling Pathway Activities Resolves K-Ras/N-Ras Mutation Paradox in Colon Epithelial Cell Response to Inflammatory Cytokine Stimulation”, Integrative Biology 2: 202-208 (2010).
  3. Lazzara, M.J., K. Lane, R. Chan, P.J. Jasper, M.B. Yaffe, P.K. Sorger, T. Jacks, B.G. Neel, and D.A. Lauffenburger, “Impaired SHP2-Mediated ERK Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with EGFR-Activating Mutations”, Cancer Res. 70: 3843-3850 (2010).
  4. Das, A., D.A. Lauffenburger, H. Asada, and R.D. Kamm, “A Hybrid Continuum-Discrete Modelling Approach to Predict and Control Angiogenesis: Analysis of Combinatorial Growth Factor and Matrix Effects on Vessel-Sprouting Morphology”, Phil. Trans. Roy. Soc. A 368: 2937-2960 (2010).
  5. Prince, R.N., E.R. Schreiter, P. Zou, H.S. Wiley, A.Y. Ting, R.T. Lee, and D.A. Lauffenburger, “The Heparin-Binding Domain of HB-EGF Mediates Localization to Cell-Cell Contact Sites and Prevents HB-EGF Release”, J. Cell Sci. 123: 2308-2318 (2010).
  6. Cosgrove, B.D., L.G. Alexopoulos, T.-c. Hang, B.S. Hendriks, P.K. Sorger, L.G. Griffith, and D.A. Lauffenburger, “Cytokine-Associated Drug Toxicity in Human Hepatocytes is Associated with Signaling Network Dysregulation”, Molec. BioSyst. (in press, 2010).
  7. Joslin, E.J., H. Shankaran, L.K. Opresko, N. Bollinger, D.A. Lauffenburger, and H.S. Wiley, “Structure of the EGF Receptor Transactivation Circuit Integrates Multiple Signals with Cell Context”, Molec. BioSyst. (in press, 2010).
  8. Spangler, J.B., J.R. Neil, S. Abramovitch, Y. Yarden, F.M. White, D.A. Lauffenburger, and K.D. Wittrup, “Combination Antibody Treatment Downregulates EGF Receptor by Inhibiting Endosomal Recycling”, Proc. Natl. Acad. Sci. USA 107: 13252-13257 (2010).
  9. Alexopoulos, L.G., J. Saez-Rodriguez, B.D. Cosgrove, D.A. Lauffenburger, and P.K. Sorger, “Networks Inferred from Biochemical Data Reveal Profound Differences in TLR and Inflammatory Signaling Between Normal and Transformed Hepatocytes”, Molec. Cell. Proteomics 9: 1849-1865 (2010).
  10. Espelin, C.W., A. Goldsipe, P.K. Sorger, D.A. Lauffenburger, D. de Graaf, and B.S. Hendriks, “Elevated GM-CSF and IL-1β Levels Compromise the Ability of p38 MAPK Inhibitors to Modulate TNFα Levels in the Human Monocytic/Macrophage U937 Cell Line”,Molec. BioSyst. 6: 1956-1972 (2010).
  11. Naegle, K.M., M. Gymrek, B.A. Joughin, J.P. Wagner, R.E. Welsch, M.B. Yaffe, D.A. Lauffenburger, and F.M. White, “PTMScout: A Web Resource for Analysis of High-Throughput Post-Translational Proteomic Studies”, Molec. Cell. Proteomics 9: 2558-2570 (2010).
  12. Das, A., Lauffenburger D.A., H. Asada, and R.D. Kamm, “Determining Cell Fate Transition Probabilities to VEGF/AngI Levels: Relating Computational Modeling to Microfluidic Angiogenesis Studies”, Cell. Molec. Bioeng. 3: 345-360 (2010).
  13. Paradise, R.K., D.A. Lauffenburger, and K.J. Van Vliet, “Acidic Extracellular pH Promotes Activation of Integrin αvβ3”, PLoS One 6: e15746 (2011).
  14. Jiang, H., J.R. Pritchard, R.T. Williams, D.A. Lauffenburger, and M.T. Hemann, “A Mammalian Functional Genetic Approach to Characterizing Cancer Therapeutics”, Nature Chem. Biol. 7: 92-100 (2011).
  15. Bagheri, N., M. Shiina, D.A. Lauffenburger, and W.M. Korn, “A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK Inhibition”, PLoS Comp. Biol. 7: e1001085 (2011).
  16. Morris, M.K., J. Saez-Rodriguez, D.C. Clarke, P.K. Sorger, and D.A. Lauffenburger, “Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli”, PLoS Comp. Biol. 7: e1001099 (2011).
  17. Peyton, S.R., I. Kalcioglu, J.C. Cohen, A.P. Runkle, K.J. Van Vliet, D.A. Lauffenburger, and L.G. Griffith, “Marrow-Derived Stem Cell Motility in 3D Synthetic Scaffold is Governed by Geometry along with Adhesivity and Stiffness”, Biotech. Bioeng. 108: 1181-1193 (2011).
  18. Lau, K.S., A.M. Juchheim, K.R. Cavaliere, S.R. Philips, D.A. Lauffenburger, and K.M. Haigis, “In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of MAPK Modulation of TNFa-induced Apoptosis and Proliferation”, Science Signaling 4: ra16 (2011).
  19. Miller, M.A., L. Barkal, K. Jeng, A. Herrlich, M. Moss, L.G. Griffith, and D.A. Lauffenburger, “Proteolytic Activity Matrix Analysis (PrAMA) for Simultaneous Detection of Multiple Protease Activities”, Integr. Biol. 3: 422-438 (2011).
  20. Palmer, M.J., V.S. Mahajan, J. Chen, D.J. Irvine, and D.A. Lauffenburger, “Signaling Thresholds Govern Heterogeneity in IL-7 Receptor-Mediated Responses of Naïve CD8+ T-Cells”, Immunol. Cell Biol. 89: 581-594 (2011).
  21. Roussos, E.T., M. Balsamo, S.K. Alford, J.B. Wyckoff, B. Gligorijevic, Y. Wang, M. Pozzuto, R. Stobezki, S. Goswami, J.E. Segall, D.A. Lauffenburger, A.R. Bresnick, F.B. Gertler, and J.S. Condeelis, “MenaINV Promotes Multicellular Streaming Motility and Transendothelial Migration in a Mouse Model of Breast Cancer”, J. Cell Science 124: 2120-2131 (2011).
  22. Naegle, K.M., R.E. Welsch, M.B. Yaffe, F.M. White, and D.A. Lauffenburger, “MCAM: Multiple Clustering Analysis Methodology for Deriving Hypotheses and Insights from High-Throughput Proteomic Datasets”, PLoS Comp Biol 7: e1002119 (2011).
  23. Chen, C.-H., A. Sarkar, Y.-A. Song, M. Miller, L.G. Griffith, D.A. Lauffenburger, and J. Han, “Enhancing Protease Activity Assay in Droplet-Based Microfluidics using a Biomolecule Concentrator”, J. Am. Chem. Soc. 133: 10368-10371 (2011).
  24. Wu, S., A. Wells, L.G. Griffith, and D.A. Lauffenburger, “Controlling Multi-Potent Stromal Cell Migration by Integrating ‘Course-Graining’ Materials and ‘Fine-Tuning’ Small Molecules via Decision Tree Modeling”, Biomaterials 32: 7524-7531 (2011).
  25. Saez-Rodriguez, J., L. Alexopoulos, M.-S. Zheng, M.K. Morris, D.A. Lauffenburger, and P.K. Sorger, “Comparing Signaling Networks Between Normal and Transformed Hepatocytes Using Discrete Logic Models”, Cancer Res. 71: 5400-5411 (2011).
  26. Pritchard, J.R., L.A. Gilbert, C.E. Meacham, J.L. Ricks, H. Jiang, D.A. Lauffenburger, and M.T. Hemann, “Bcl-2 Family Genetic Profiling Reveals Microenvironment-Specific Determinants of Chemotherapeutic Response”, Cancer Res. 71: 5850-5858 (2011).
  27. Kleiman, L.B., T. Maiwald, H. Conzelmann, D.A. Lauffenburger, and P.K. Sorger, “Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding”, Molec. Cell 43: 723-737 (2011).
  28. Kim, H.D., A.S. Meyer, J.P. Wagner, S.K. Alford, A. Wells, F.B. Gertler, and D.A. Lauffenburger, “Signaling Network State Predicts Twist-Mediated Effects on Breast Cell Migration Across Diverse Growth Factor Contexts”, Molec. Cell. Proteomics 10: M111.008433 (2011).
  29. Moss, M.L., G. Powell, M.A. Miller, L. Edwards, Q. Bin, Q.X. Sang, B. De Strooper, I. Tesseur, S.F. Lichtenthaler, M. Taverna, J.L. Zhang, C. Dingwall, T. Ferdous, U. Schlomann, P. Zhou, L. Griffith, D.A. Lauffenburger, R. Petrovich, and J.W. Bartsch, “ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein”, J. Biol. Chem. 286: 40443-40451 (2011).
  30. Aldridge, B.B., S. Gaudet, D.A. Lauffenburger, and P.K. Sorger, “Lyapunov Exponents and Phase Diagrams Reveal Multi-Factorial Control over TRAIL-Induced Apoptosis”, Molec. Syst. Biol. 7: 553 (2011).
  31. Hang, T., D.A. Lauffenburger, L.G. Griffith, and D.B. Stolz, “Lipids Promote Survival, Proliferation, and Maintenance of Differentiation of Rat Liver Sinusoidal Endothelial Cells in Vitro”, Am. J. Physiol. Gastrointest. Liver Physiol. 302: G375-G388 (2012).
  32. Tentner AR, MJ Lee, GJ Ostheimer, LD Samson, DA Lauffenburger, MB Yaffe, “Combined Experimental and Computational Analysis of DNA Damage Signaling Reveals Context-Dependent Roles for ERK in Apoptosis and G1/S Arrest after Genotoxic Stress”, Molec. Syst. Biol. 8: 568 (2012).
  33. Han, Q., N. Bagheri, E.M. Bradshaw, D.A. Hafler, D.A. Lauffenburger, and J.C. Love, “Polyfunctional Responses by Human T Cells Result from Sequential Release of Cytokines”, Proc. Natl. Acad. Sci. USA 109: 1607-1612 (2012).
  34. Stains CI, NC Tedford, TC Walkup, E Lukovic, BN Goguen, LG Griffith, DA Lauffenburger, and B Imperiali, “Interrogating Signaling Nodes Involved in Cellular Transformations using Kinase Activity Probes”, Chem. & Biol. 19: 210-217 (2012).
  35. Morris, M.K., Z. Shriver, R. Sasisekharan, and D.A. Lauffenburger, “Querying Quantitative Logic Models to Study Intracellular Signaling Networks and Cell/Cytokine Interactions”, Biotech. J. 7: 374-386 (2012).
  36. Meyer, A.S., S.K. Hughes-Alford, J.E. Kay, A. Castillo, A. Wells, F.B. Gertler, and D.A. Lauffenburger, “2D Protrusion but not Motility Predicts Growth Factor-Induced Cancer Cell Migration in 3D Collagen”, J. Cell Biol. 197: 721-729 (2012).
  37. Lau, K.S., T. Zhang, K.R. Kendall, D.A. Lauffenburger, N.S. Gray, and K.M. Haigis, “BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner”, PLoS ONE 7: e41343 (2012).
  38. Kirouac, D.C., J. Saez-Rodriguez, J. Swantek, J.M. Burke, D.A. Lauffenburger, and P.K. Sorger, “Creating and Analyzing Pathway and Protein Interaction Compendia for Modeling Signal Transduction Networks”, BMC Syst. Biol. 6: 29 (2012).
  39. Miller, M., M. Hafner, E. Sontag, N. Davidsohn, S. Subramaniam, P.E.M. Purnick, D.A. Lauffenburger, and R. Weiss, “Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity”, PLoS Comp. Biol.8 e1002579 (2012).
  40. Joughin, B.A., C., Liu, D.A. Lauffenburger, C.W.V. Hogue, and M.B. Yaffe, “Protein Kinases Display Minimal Interpositional Dependence on Substrate Sequence: Potential Implications for the Evolution of Signalling Networks”, Phil. Trans. Roy. Soc. B 367: 2574-2583 (2012).
  41. Gupton, S.L., D. Riquelme, S.K. Hughes-Alford, J. Tadros, S.S. Rudina, R.O. Hynes, D.A. Lauffenburger, and F.B. Gertler, “Mena Binds a5 Integrin Directly and Modulates a5b1 Function”, J. Cell Biol. 198: 657-676 (2012).
  42. Naegle, K.M., F.M. White, D.A. Lauffenburger, and M.B. Yaffe, “Robust Co-Regulation of Tyrosine Phosphorylation Sites on Proteins Reveals Novel Protein Interactions”, Molec. BioSyst. 8 2771-2782 (2012).
  43. Noonan, E.M., D. Shah, M.B. Yaffe, D.A. Lauffenburger, and L.D. Samson, “O6-Methylguanine DNA Lesions Induce an Intra-S-Phase Arrest from which Cells Exit into Apoptosis Governed by Early and Late Multi-Pathway Signaling Network Activation”, Integr. Biol. 4 1237-1255 (2012).
  44. Lau, K.S., V. Cortez-Reta, S.R. Philips, M.J. Pittet, D.A. Lauffenburger, and K.M. Haigis, “Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNFa-Induced Apoptosis in the Intestinal Epithelium”, PLoS Biol. 10: e1001393 (2012).
  45. Terfve C.D.A., T. Cokelaer, D. Henriques, A. MacNamara, E. Goncalves, M.K. Morris, M. van Iersel, D.A. Lauffenburger, and J. Saez-Rodriguez, “CellNOptR: A Flexible Toolkit to Train Protein Signaling Networks to Data Using Multiple Logic Formalisms”, BMC Syst. Biol. 6: 133 (2012).
  46. Mitsos A., I.N. Melas, M.K. Morris, J. Saez-Rodriguez, D.A. Lauffenburger, and L.G. Alexopoulos, “Non-Linear Programming Formulation for Quantitative Modeling of Protein Signal Transduction Pathways”, PLoS One 7: e50085 (2012).
  47. Clarke D.C., M.K. Morris, and D.A. Lauffenburger, “Normalization and Statistical Analysis of Multiplexed Bead-Based Immunoassay Data using Mixed-Effects Modeling”, Molec. Cell. Proteomics 12: 245-262 (2012).
  48. Yamanaka Y.J., G.L. Szeto, T.M. Gierahn, T.L. Forcier, K.F. Benedict, M.S. Brefo, D.A. Lauffenburger, D.J. Irvine, and J.C. Love, “Cellular Barcodes for Efficiently Profiling Single-Cell Secretory Responses by Microengraving”, Anal. Chem. 84: 10531-10536 (2012).
  49. Pritchard J.P., P.M. Bruno, L.A. Gilbert, K.L. Capron, D.A. Lauffenburger, and M.T. Hemann, “Defining Principles of Combination Drug Mechanisms of Action”, Proc. Natl. Acad. Sci. USA 110: E170-179 (2013).
  50. Paradise R.K., M. Whitfield, D.A. Lauffenburger, and K.J. Van Vliet, “Directional Cell Migration in an Extracellular pH Gradient”, Expt. Cell Res. 319: 487-497 (2013).
  51. Chen C.H., M.A. Miller, A. Sarkar, M.T. Beste, K.B. Isaacson, D.A. Lauffenburger, L.G. Griffith, and J. Han, “Multiplexed Protease Activity Assay for Low-Volume Clinical Samples using Droplet-Based Microfluidics and its Application to Endometriosis”, J. Am. Chem. Soc. 135: 1645-1648 (2013).
  52. Huang S.C., D.C. Clarke, A. Labadorf, C.R. Chouinard, W. Gordon, D.A. Lauffenburger, and E. Fraenkel, “Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-Induced Signaling”, PLoS Comp. Biol. 9: e1002887 (2013).
  53. Rimchala, T., R.D. Kamm, and D.A. Lauffenburger, “Endothelial Cell Phenotypic Behaviors Cluster into Dynamic Transition Programs Modulated by Angiogenic and Angiostatic Cytokines”, Integr. Biol. 5: 510-522 (2013).
  54. Miller M.A., A.S. Meyer, M.T. Beste, Z. Lasisi, S. Reddy, K.W. Jeng, C.-H. Chen, J. Han, K. Isaacson, L.G. Griffith, and D.A. Lauffenburger, “ADAM-10 and -17 Regulate Endometriotic Cell Migration via Concerted Ligand and Receptor Shedding Feedback on Kinase Signaling”, Proc. Natl. Acad. Sci. USA 110: E2074-E2083 (2013).
  55. Dang, M., N. Armbruster, M.A. Miller, E. Cermeno-Blondet, M. Hartmann, G.W. Bell, D. Root, D.A. Lauffenburger, H. Lodish, and A. Herrlich, “Regulated ADAM17-dependent EGF Family Ligand Release by Substrate-Selecting Signaling Pathways”, Proc. Natl. Acad. Sci. USA 110: 9776-9781 (2013).
  56. Pritchard, J.R., P.M. Bruno, M.T. Hemann, and D.A. Lauffenburger, “Predicting Cancer Drug Mechanisms of Action using Molecular Signatures”, Molec. BioSyst. 9: 1604-1619 (2013).
  57. Wagner, J.P., A. Wolf-Yadlin, M. Sevecka, J.K. Grenier, D.E. Root, D.A. Lauffenburger, and G. MacBeath, “Receptor Tyrosine Kinases Fall into Distinct Classes Based on their Inferred Signaling Networks”, Science Signaling 6: ra58 (2013).
  58. Meyer, A.S., M.A. Miller, F.B. Gertler, and D.A. Lauffenburger, “AXL Diversifies EGFR Signaling and Mitigates Response to EGFR-Targeted Therapeutics in Triple-Negative Breast Carcinoma Cells”, Science Signaling 6 : ra66 (2013).
  59. Miraldi, E.R., H. Sharfi, R.H. Friedline, H. Johnson, T. Zhang, K.S. Lau, H.J. Ko, T.G. Curran, K.M. Haigis, M.B. Yaffe, R. Bonneau, D.A. Lauffenburger, B.B. Kahn, J.K. Kim, B.G. Neel, A. Saghatelian, and F.M. White, “Molecular Network Analysis of Phosphotyrosine and Lipid Metabolism in Hepatic PTP1b-Deletion Mice”, Integrative Biol. 5: 940-963 (2013).
  60. Simmons, R.P., E.P. Scully, E.E. Groden, K.F. Benedict, J.J. Chang, K. Lane, J. Lifson, E. Rosenberg, D.A. Lauffenburger, and M. Altfeld, “HIV-1 Infection Induces Strong Production of IP-10 through TLR7/9-Dependent Pathways”, AIDS 27: 2505-2517 (2013).
  61. Jamison, J., D. Lauffenburger, J.C.-H. Wang, and A. Wells, “PKCd Localization at the Membrane Increases Matrix Traction Force Dependent on PLCg1/EGFR Signaling”, PLoS One 8: e77434 (2013).
  62. Lau, K.S., S. Schrier, J. Gierut, J. Lyons, D.A. Lauffenburger, and K.M. Haigis, “Network Analysis of Differential Ras Isoform Mutation Effects on Intestinal Epithelial Responses to TNFα”, Integrative Biol. 5: 1355-1365 (2013).
  63. Melas, I.N., D.A. Lauffenburger, L.G. Alexopoulos, “Identification of Signaling Pathways Related to Drug Efficacy in Hepatocellular Carcinoma via Integration of Phosphoproteomic, Genomic, and Clinical Data”, Proc. IEEE Eng. Med. Biol. Soc. July: 2680-2683 (2013).
  64. Hang, T.-C., N.C. Tedford, R.J. Reddy, T. Rimchala, A. Wells, F.M. White, R.D. Kamm, and D.A. Lauffenburger, “Vascular Endothelial Cell Growth Factor and Platelet Factor 4 Inputs Modulate Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context”, Molec. Cell. Proteomics 12: 3704-3718 (2013).
  65. Wheeler, S.E., J.T. Borenstein, A.M. Clark, M.R. Ebrahimkhani, I.J. Fox, L. Griffith, W. Inman, D. Lauffenburger, T. Nguyen, V.C. Pillai, R. Prantil-Braun, D.B. Stolz, D. Taylor, T. Ulrich, R. Venkataraman, A. Wells, and C. Young, “All-Human Microphysiological Model of Metastasis Therapy”, Stem Cell Res. Ther. 4 (suppl 1): S11 (2013).
  66. Arneja, A., H. Johnson, L. Gabrovsek, D.A. Lauffenburger, and F.M. White, “Qualitatively Different T Cell Phenotypic Responses to IL2 versus IL15 are Unified by Identical Dependencies on Receptor Signal Strength and Duration”, J. Immunol. 192: 123-135 (2014).
  67. Zhao, B., J.R. Pritchard, D.A. Lauffenburger, and M.T. Hemann, “Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination Therapy”, Cancer Discovery 4: 166-174 (2014).
  68. Beste, M.T., N. Pfaffle-Doyle, E.A. Prentice, S.N. Morris, D.A. Lauffenburger, K.B. Isaacson, and L.G. Griffith, “Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun-Regulated Macrophage Activation”, Science Trans. Med. 6: 222ra16 (2014).
  69. Sarkar, A., S. Kolitz, D.A. Lauffenburger, and J. Han, “Microfluidic Probe for Single-Cell Analysis in Adherent Tissue Culture”, Nature Comm. 5: 3421 (2014).
  70. Tape, C.J., I.C. Norrie, J.D. Worboys, L. Lim, D.A. Lauffenburger, and C. Jorgensen, “Cell-Specific Labeling Enzymes for Analysis of Cell-Cell Communication in Continuous Co-Culture”, Molec. Cell. Proteomics 13: 1866-1876 (2014).
  71. Zhao, B., M.T. Hemann, and D.A. Lauffenburger, “Intratumor Heterogeneity Alters Most Effective Drugs in Designed Combinations”, Proc. Natl. Acad. Sci. USA 111: 10773-10778 (2014).
  72. Cheow, L.F., A. Sarkar, S. Kolitz, D. Lauffenburger, and J. Han, “Detecting Kinase Activities from Single Cell Lysate using Concentration-Enhanced Mobility Shift Assay”, Analyt. Chem. 86: 7455-7462 (2014).
  73. Clark, A.M., S.E. Wheeler, D.P. Taylor, V.C. Pillai, C.L. Young, R. Prantil-Baun, T. Nguyen, D.B. Stolz, J.T. Borenstein, D.A. Lauffenburger, R. Venkataramanan, L.G. Griffith, and A. Wells, “A Micro-Physiological System Model of Therapy for Liver Micro-metastases”, Exp. Biol. Med. 239: 1170-1179 (2014).
  74. Muraro, D., D.A. Lauffenburger, and A. Simmons, “Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes”, PLoS One 9: e108264 (2014).
  75. Tape, C.J., J.D. Worboys, J. Sinclair, R. Gourlay, J. Vogt, K.M. McMahon, M. Trost, D.A. Lauffenburger, D.J. Lamont, and C. Jorgensen, “Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and TI-MAC”, Analyt. Chem. 86: 10296-10302 (2014).
  76. Palmer, C.D., J. tomassilli, M. Sirignano, M.R. Tejeda, K.B. Arnold, D. Che, D.A. Lauffenburger, S. Jost, T. Allen, K.H. Mayer, and M. Altfeld, “Enhanced Immune Activation Linked to Endotoxemiain HIV-1 Seronegative MSM”, AIDS 28: 2162-2166 (2014).
  77. Wheeler, S.E., A.M. Clark, D.P. Taylor, C.L. Young, V.C. Pillai, D.B. Stolz, R. Venkataraman, D. Lauffenburger, L. Griffith, and A. Wells, “Spontaneous Dormancy of Metastatic Breast Cancer Cells in an All-Human Liver Microphysiologic System”, Brit. J. Cancer 111: 2342-2350 (2014).
  78. Schlomann, U., G. Koller, C. Conrad, T. Ferdous, P. Golfi, A.M. Garcia, S. Hoefling, M. Parsons, P. Costa, R. Soper, M. Bossard, T. Hagemann, R. Roshani, N. Sewald, R.R. Ketchem, M.L. Moss, F.H. Rasmussen, M.A. Miller, D.A. Lauffenburger, D.A. Tuveson, C. Nimsky, and J.W. Bartsch, “ADAM8 as a Drug Target in Pancreatic Cancer”, Nature Comm. 6: 6175 (2015).
  79. Ng, E.X., M.A. Miller, T. Jing, D.A. Lauffenburger, and C.H. Chen, “Low-Volume Multi-Plexed Proteolytic Activity Assay and Inhibitor Analysis through a Pico-Injector Array”, Lab Chip 15: 1153-1159 (2015).
  80. Li, J.Z., K.B. Arnold, J. Lo, A.-S. Dugast, J. Plants, H.J. Ribaudo, K. Cesa, A. Heisey, D.R. Kuritzkes, D.A. Lauffenburger, G. Alter, A. Landay, S. Grinspoon, and F. Pereyra, “Differential Levels of Soluble Inflammatory Markers by HIV Controller Status and Demographics”, Open Forum Infectious Diseases 2: ofu117 (2015).
  81. Wu, L. A.M. Claas, A. Sarkar, D.A. Lauffenburger, and J.Y. Han, “High-Throughput Protease Activity Cytometry Reveals Dose-Dependent Heterogeneity in PMA-Mediated ADAM17 Activation”, Integr. Biol. 7: 513-524 (2015).
  82. Travers, T., H. Shao, B.A. Joughin, D.A. Lauffenburger, A. Wells, and C.J. Camacho, “Tandem Phosphorylation within an Intrinsically Disordered Region Regulates ACTN4 Function”, Science Signaling 8: ra51 (2015).
  83. Masson, L., K.B. Arnold, F. Little, K. Mlisana, D. Lewis, N. Mhkize, S. Ngcapu, L. Johnson, D.A. Lauffenburger, Q.A. Karim, S.S. Karim, and J.S. Passmore, “Genital Inflammation and the Risk of HIV Acquisition in Women”, Clin. Infect. Dis. 61: 260-269 (2015).
  84. Melas, I.N., T. Sakellaropoulos, F. Iorio, L.G. Alexopoulos, W.Y. Loh, D.A. Lauffenburger, J. Saez-Rodriguez, and J.P. Bai, “Identification of Drug-Specific Pathways based on Gene Expression Data: Application to Drug-Induced Lung Injury”, Integr. Biol. 7: 904-920 (2015).
  85. Birse, K., K.B. Arnold, R.M. Novak, S. McCorrister, S. Shaw, G.R. Westmacott, T.B. Ball, D.A. Lauffenburger, and A. Burgener, “Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling are Enhanced during the Luteal Phasse of the Menstrual Cycle: Implications for HIV Susceptibility”, J. Virology 89: 8793-8805 (2015).
  86. Meyer, A.S., A.J.M. Zweemer, and D.A. Lauffenburger, “The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity”, Cell Systems 1: 25-36 (2015).
  87. Hughes, S.K., M.J. Oudin, J. Tadros, J. Neil, A. Del Rosario, B.A. Joughin, L. Ritsma, J. Wyckoff, E. Vasile, R. Eddy, U. Philippar, A. Lussiez, J.S. Condeelis, J. van Rheenan, F. White, D.A. Lauffenburger, and F.B. Gertler, “PTP1B-Dependent Regulation of Receptor Tyrosine Kinase Signaling by the Actin-Binding Protein Mena”, Molec. Biol. Cell 26: 3867-3878 (2015).
  88. Miller, M.A., M.L. Moss, G. Powell, R. Petrovich, L. Edwards, A.S. Meyer, L.G. Griffith, and D.A. Lauffenburger, “Targeting Autocrine HB-EGF Signaling with Specific ADAM12 Inhibition using Recombinant ADAM12 Prodomain”, Sci. Reports 5: 15150 (2015).
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