News: The Foundry is now Asimov Labs! Please find us in our new home at Asimov
Our Team
The Foundry core facility was located in the Broad Institute and was closely embedded with their platforms in DNA sequencing, transcriptomics/proteomics, and chemical screening. It was partnership between the Synthetic Biology Center at MIT (Christopher Voigt, Co-Director) and the Broad Technology Labs (Rob Nicol, Director). Ben Gordon is the Foundry Director.
Three teams are implemented the pipeline at the core facility:
Design Team
- Bioinformatics to harness genome databases
- Rapid optimization of multi-gene designs
- De novo pathway design for non-natural chemicals and materials
- Control of timing and conditions for gene activation
- Genetic part design for diverse organisms
- Genome-scale computer aided design (CAD)
- Actionable design from integrated –omics and screening data
Build Team
- Low-cost multiplex DNA construction
- Novel chemistries for DNA assembly
- Miniaturization and automation
- Integration of construction and sequencing technologies
- Implementation of manufacturing best practices
- LIMS software and bug/QC tracking
Cellular Analytics Team
- Simultaneous proteomic/transcriptomic measurements
- Emulsions systems and single cell –omics
- Extraction of genetic part performance from –omics data
- Data integration and extraction of actionable design rules
- Rapid prototyping of designs pre-transformation.