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Goal

Define the paradigms by which carbohydrate binding proteins function in cellular communication.

 

Specific Objectives:

  • Provide an administrative structure to oversight for the program, approve the selection of representative CBPs for study on an ongoing basis, and ensure that program resources are efficiently used to achieve the program goal.


  • Establish Scientific Core Resources to develop essential tools and a platform of information required to achieve the Specific Aims for each CBP selected for study.


  • Establish a consortium of Participating Investigators to utilize the resources and information generated by the Cores and participate in achieving the Specific Aims by investigating the roles of the CBPs and their cognate carbohydrate ligands in cellular communication.


  • Develop and maintain glycomics databases of human and murine CBPs and glycosyltransferase genes, and mammalian carbohydrate structures. Novel CBP and key glycosyltransferases identified will be flagged as candidates for study by the program.


  • Develop and maintain a relational database of all program information with internet based interfaces for dissemination of all program derived data to the participating investigators and the public.

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