Active model for folding the genome

Can activity account for features of chromatin organization?

N. Ganai, S. Sengupta, and G.I. Menon, Nucleic Acid Res. 42, 4145 (2014)

Particle models of phase separation due to activity:

     

Simple model for a heterogeneous active polymer:

Linear model can be solved exactly:

Next (Compartments) Outline Chromatin Passive folding Active folding Compartments Correlated Activity Dynamic signatures Summary