Dynamic signatures

Passive or active?

 

Super resolution live cell imaging tracks dynamics of loci:

Velocity correlations show time irreversible motion:

Quantifying and measuring time irreversibility:

Measured loci need to straddle an activity boundary:

Cell motion makes it difficult to track absolute positions, 3 loci measurements to track irreversibility:

Next (Summary) Outline Chromatin Passive folding Active folding Compartments Correlated Activity Dynamic signatures Summary