3D structure of the genome

DNA organization:  Over 2 meters of DNA are densely packed as chromatic fibers into the cell nucleus of only a few microns in size:

Chromosome Conformation Capture (3C, Hi-C, ...) map out pairwise regions of chromatin are in contact:

     

A prominent feature is compartments of active/accessible (euchromatin, A) and silent/closed (heterochromatin, B):

                                                                                           T Misteli, Cell, 183(1): 28-45 (2018)                 M Falk et al. Nature. 570, 395(2019)

Compartments spatially isolate active and inactive chromatin:

Next (Passive folding) Outline Chromatin Passive folding Active folding Compartments Correlated Activity Dynamic signatures Summary