Publications
“Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases.” Shende, V. V.; Harris, N. R.; Sanders, J. N.; Movassaghi, M.; Houk. K. N.; Sherman, D. H. Agnew. Chem. Int. Ed. 2023.
“Total Synthesis of (-)-Voacinol and (-)-Voacandimine C.” Flynn, K. M.; Myeong, I.-S.; Pinto, T.; Movassaghi, M. J. Am. Chem. Soc. 2022, 144, 9126–9131.
“Total Synthesis and Stereochemical Assignment of (–)-Psychotridine.” Scott, T. Z.; Armelin, V. F.; Movassaghi, M. Org. Lett. 2022, 24, 2160–2164.
“Total Synthesis of Himastatin.” D’Angelo, K.; Schissel, C.; Pentelute, B.; Movassaghi, M. Science 2022, 375, 894–899.
“Directed Palladium Catalyzed Acetoxylation of Indolines. Total Synthesis of N-Benzoyl-cylindrocarine.” Flynn, K. M.; While, K. L.; Movassaghi, M. J. Org. Chem. 2022, 87, 2975–2984.
“Synthesis of (–)-Kopsifoline A and (+)-Kopsifoline E.” Myeong, I.-S., Avci, N. H.; Movassaghi, M. Org. Lett. 2021, 23, 9118–9122.
“Chemoselective α-Sulfidation of Amides Using Sulfoxide Reagents.” Leypold, M.; D' Angelo, K. D.; Movassaghi, M. Org. Lett. 2020, 22, 8802–8807.
“Structure and Function of NzeB, a Versatile C–C and C–N Bond Forming Diketopiperazine Dimerase.” Shende, V. S.; Khatray, Y.; Newmister, S. A.; Sanders, J. N.; Lindovska, P.; Yu, F.; Doyon, T.; Houk. K. N.; Movassaghi, M.; Sherman, D. H. J. Am. Chem. Soc. 2020, 142, 17413–17424.
“n→π* Interactions modulate the disulfide reduction potential of epidithiodiketopiperazines.” Kilgore, H. R.; Olsson, C. R.; D'Angelo, K. A.; Movassaghi, M.; Raines, R. T. J. Am. Chem. Soc. 2020, 142, 15107–15115.
“Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization.” Olsson, C. R.; Payette, J. N.; Cheah, J. H.; Movassaghi, M. J. Org. Chem. 2020, 85, 4648–4662.
“Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives.” Pompeo, M. M.; Cheah, J. H.; Movassaghi, M. J. Am. Chem. Soc. 2019, 141, 14411–14420.
“Mechanism of Permanganate Promoted Dihydroxylation of Complex Diketopiperazines: Critical Roles of Counter-Cation and Ion-Pairing.” Haines, B. E.; Nelson, B. M.; Grandner, J. M; Kim, J.; Houk, K. N; Movassaghi, M.; Musaev, D. G. J. Am. Chem. Soc. 2018, 140 (41), 13375–13386.
“Enantioselective Synthesis of (-)-Vallesine: Late-Stage C17-Oxidation via Complex Indole Boronation.” Antropow, A. H.; Garcia, N. R.; White, K.; Movassaghi, M. Org. Lett. 2018 , 20 , 3647–3650.
“Concise Total Synthesis of (+)-Asperazine A and (+)-Pestalazine B.” Nelson, B. M.; Loach, R. P.; Schiesser, S.; Movassaghi, M. Org. Biomol. Chem. 2018, 16, 202–207.
“Synthesis of Antibiotics and Related Molecules. ” Movassaghi, M. van der Donk, W. A. J. Org. Chem. 2018 , 83 , 6826–6828.
“Biogenetic Considerations. ” Movassaghi, M. Tetrahedron 2018 , 74 , 5583.
“Concise Synthesis of (–)-Hodgkinsine, (–)-Calycosidine, (–)-Hodgkinsine B, (–)-Quadrigemine C, and (–)-Psycholeine via Convergent and Directed Modular Assembly of Cyclotryptamines.” Lindovska, P.; Movassaghi, M. J. Am. Chem. Soc. 2017, 139, 17590–17596.
“Quantitative Modeling of Bis(pyridine)silver (I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates.” Bischoff, A. J.; Nelson, B. M.; Niemeyer, Z. L.; Sigman, M. S.; Movassaghi, M. J. Am. Chem. Soc. 2017, 139, 15539–15547.
“Enantioselective Total Synthesis of (–)-Deoxoapodine.” Kang, T.; White, K. L.; Mann, T. J.; Hoveyda, A. H.; Movassaghi, M. Angew. Chem. Int. Ed. 2017, 56, 13857.
“Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis.” Antropow, A. H.; Xu, K.; Buchsbaum, R. J.; Movassaghi, M. J. Org. Chem. 2017, 82, 7720–7731.
“Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine Via Late-Stage Oxidation of (+)-Fendleridine Derivatives.” White, K. L.; Movassaghi, M. J. Am. Chem. Soc. 2016, 138, 11383–11389.
“Convergent and Biomimetic Enantioselective Total Synthesis of (-)-Communesin F.” Lathrop, S. P.; Pompeo, M.; Chang, W.-T. T.; Movassaghi, M. J. Am. Chem. Soc. 2016, 138, 7763–7769.
“Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A.” Loach, R. P.; Fenton, O. S.; Movassaghi, M. J. Am. Chem. Soc. 2016, 138, 1057–1064.
“The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis.” Xu, K.; Tian, X.; Oh, S. Y.; Movassaghi, M.; Naber, S. P.; Kuperwasser, C.; Buchsbaum, R. J. Breast Cancer Res. 2016, 18, 14.
“Direct C7 Functionalization of Tryptophan. Synthesis of Methyl (S)-2-((tert-Butoxycarbonyl)amino)-3-(7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-3-yl)propanoate.” Amaike, K.; Loach, R. P.; Movassaghi, M. Org. Synth. 2015, 92, 373–385.
“Concise Total Synthesis of (+)-Luteoalbusins A and B.” Adams, T. C.; Payette, J. N.; Cheah, J. H.; Movassaghi, M. Org. Lett. 2015, 17, 4268–4271.
“Direct Observations of Intermediates Involved in the Bischler-Napieralski Reaction.” White, K. L.; Mewald, M.; Movassaghi, M. J. Org. Chem. 2015, 80, 7403–7411.
“Electrophilic carbonyl activation: competing condensative cyclizations of tryptamine derivatives.” Liu, F.; Movassaghi, M. Tetrahedron Lett. 2015 (Memorial Symposium for Prof. H. H. Wasserman), 56, 2995–3000.
“Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids.” Kim, J.; Movassaghi, M. Acc. Chem. Res. 2015, 48, 1159–1171.
“C7-Derivatization of 3-Alkylindoles Including Tryptophans and Tryptamines.” Loach, R. P.; Fenton, O. S.; Amaike, K.; Siegel, D. S.; Ozkal, E.; Movassaghi, M. J. Org. Chem. 2014, 79, 11254–11263.
“Concise and Enantioselective Total Synthesis of (−)-Mehranine, (−)-Methylenebismehranine, and Related Aspidosperma Alkaloids.” Mewald, M.; Medley, J. W.; Movassaghi, M. Angew. Chem. Int. Ed. 2014, 53, 11634–11639.
“Pd(II)-Catalyzed meta-C–H Olefination, Arylation, and Acetoxylation of Indolines Using a U-Shaped Template.” Yang, G.; Lindovska, P.; Zhu, D.; Kim, J.; Wang, P.; Tang, R.-Y.; Movassaghi, M.; Yu, J.-Q. J. Am. Chem. Soc. 2014, 136, 10807–10813.
“Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (-)-Trigonoliimines.” Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. J. Org. Chem. 2014, 79, 473–486.
“Application of Diazene-Directed Fragment Assembly to the Total Synthesis and Stereochemical Assignment of (+)-Desmethyl-meso-chimonanthine and Related Heterodimeric Alkaloids ” Lathrop, S. P.; Movassaghi, M. Chem. Sci. 2014, 5, 333–340.
“(+)-11,11'-Dideoxyverticillin A”. Kim, J.; Movassaghi, M., In Total Synthesis of Natural Products, Li, J. J.; Corey, E. J., Ed.; Springer-Verlag: Berlin Heidelberg, (2013); p 211.
“Synthesis and Anticancer Activity of all known (-)-Agelastatin Alkaloids.” Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. J. Org. Chem. 2013, 78, 11970–11984.
“Synthesis of Spirocyclic Indolines by Interruption of the Bischler-Napieralski Reaction” Medley, J. W.; Movassaghi, M. Org. Lett. 2013, 15, 3614–3617.
“Concise Total Synthesis of (+)-Bionectins A and C” Coste, A.; Kim, J.; Adams, T. C.; Movassaghi, M. Chem. Sci. 2013, 4, 3191–3197.
“Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids ” Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M. Chem. Sci. 2013, 4, 1646–1657.
“Robinson's Landmark Synthesis of Tropinone ” Medley, J. W.; Movassaghi, M. Chem. Commun. 2013, 49, 10775–10777.
“Total Synthesis of All (–)-Agelastatin Alkaloids”. Movassaghi, M.; Han, S., In Asymmetric Synthesis–The Essentials 2, Christmann, M, Bräse, S., Eds.; Wiley-VCH, (2012), pp 391–396.
“C–N Bond-Forming Reactions of Heteroarenes.” Ahmad, O. K.; Movassaghi, M., In Science of Synthesis: Cross-Coupling and Heck-Type Reactions, Wolfe, J. P., Ed.; Thieme: Stuttgart, (2012); Vol. 2, pp 195-214.
“Direct Synthesis of Azaheterocycles from N-Aryl/Vinyl Amides. Synthesis of 4-(Methylthio)-2-phenylquinazoline and 4-(4-Methoxyphenyl)-2-phenylquinoline.” Ahmad, O. K.; Medley, J. W.; Coste, A.; Movassaghi, M. Org. Synth. 2012, 89, 549–561.
“Concise Total Synthesis of (+)-Gliocladins B and C.” Boyer, N.; Movassaghi, M. Chem. Sci. 2012, 3, 1798–1803.
“Lithiation and Electrophilic Substitution of Dimethyl Triazones.” Han, S.; Siegel, D. S.; Movassaghi, M. Tetrahedron Lett. 2012, 53, 3722–3723.
“Radical Mediated Dimerization and Oxidation Reactions for the Synthesis of Complex Alkaloids.” Lathrop, S. P.; Kim, J.; Movassaghi, M. Chimia 2012, 66, 389–393.
“A Concise and Versatile Double-Cyclization Strategy for the Highly Stereoselective Synthesis and Arylative Dimerization of Aspidosperma Alkaloids.” Medley, J. W.; Movassaghi, M. Angew. Chem. Int. Ed. 2012, 51, 4572–4576.
“Preparation of IPNBSH and its Use in the Pd-Catalyzed Synthesis of Monoalkyl Diazenes. Synthesis of 9-Allylanthracene.” Willwacher, J.; Ahmad, O. K.; Movassaghi, M. Org. Synth. 2012, 89, 230–242.
“Concise Total Synthesis and Stereochemical Revision of (+)-Naseseazines A and B: Regioselective Arylative Dimerization of Diketopiperazine Alkaloids.” Kim, J.; Movassaghi, M. J. Am. Chem. Soc. 2011, 133, 14940–14943.
“Directed Heterodimerization: Stereocontrolled Assembly via Solvent-Caged Unsymmetrical Diazene Fragmentation.” Movassaghi, M.; Ahmad, O. K.; Lathrop, S. P. J. Am. Chem. Soc. 2011, 133, 13002–13005.
“Concise Total Synthesis and Stereochemical Revision of all (-)-Trigonoliimines.” Han, S.; Movassaghi, M. J. Am. Chem. Soc. 2011, 133, 10768–10771.
“Chemoselective and Enantioselective Oxidation of Indoles Employing Aspartyl Peptide Catalysts.” Kolundzic, F.; Noshi, M. N.; Tjandra, M.; Movassaghi, M.; Miller, S. J. J. Am. Chem. Soc. 2011, 133, 9104–9111.
“General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12'-Dideoxychetracin A.” Kim, J.; Movassaghi, M. J. Am. Chem. Soc. 2010, 132, 14376–14378.
“Total Synthesis of All (–)-Agelastatin Alkaloids.” Movassaghi, M.; Siegel, D. S.; Han, S. Chemical Science 2010, 1, 561–566.
“Dimerization of Functional Pyrroloindolizines for the Synthesis of Complex Myrmicarin Alkaloids.” Ondrus, A. E.; Kaniskan, H. U.; Movassaghi, M. Tetrahedron 2010, 66, 4784–4795.
“Total Synthesis of (–)-Himandrine.” Movassaghi, M.; Tjandra, M.; Qi, J. J. Am. Chem. Soc. 2009, 131, 9648–9650.
“Total Synthesis of (+)-11,11'-Dideoxyverticillin A.” Kim, J.; Ashenhurst, J. A.; Movassaghi, M. Science 2009, 324, 238–241.
“Reversible Dimerization of (+)-Myrmicarin 215B.” Ondrus, A. E.; Movassaghi, M. Org. Lett. 2009, 11, 2960–2963.
“Biogenetically Inspired Syntheses of Alkaloid Natural Products.” Kim, J.; Movassaghi, M. Chem. Soc. Rev. 2009, 38, 3035–3050.
“Enantioselective Total Synthesis of (–)-Acylfulvene and (–)-Irofulven.” Siegel, D. S.; Piizzi, G.; Piersanti, G.; Movassaghi, M. J. Org. Chem. 2009, 74, 9292–9304.
“Total synthesis and study of myrmicarin alkaloids.” Ondrus, A. E.; Movassaghi, M. Chem. Commun. 2009, 4151–4165.
“Synthesis of Densely Substituted Pyrimidine Derivatives.” Ahmad, O. K.; Hill, M. D.; Movassaghi, M. J. Org. Chem. 2009, 74, 8460–8463.
“Direct Dehydrative N-Pyridinylation of Amides” Medley, J. W.; Movassaghi, M. J. Org. Chem. 2009, 74, 1341–1344.
“Observations in the Synthesis of the Core of the Antitumor Illudins via an Enyne Ring Closing Metathesis Cascade.” Movassaghi, M.; Piizzi, G.; Siegel, D. S.; Piersanti, G. Tetrahedron Lett. 2009, 50, 5489–5492.
“Stereospecific Palladium-Catalyzed Entry to Monoalkyl Diazenes for Mild Allylic Reduction.” Movassaghi, M.; Ahmad, O. K. Angew. Chem. Int. Ed. 2008, 47, 8909–8912.
“Concise Total Synthesis of (+)-WIN 64821 and (–)-Ditryptophenaline.” Movassaghi, M.; Schmidt, M. A.; Ashenhurst, J. A. Angew. Chem. Int. Ed. 2008, 47, 1485–1487.
“Stereoselective Oxidative Rearrangement of 2-Aryl Tryptamine Derivatives.” Movassaghi, M.; Schmidt, M. A.; Ashenhurst, J. A. Org. Lett. 2008, 10, 4009–4012.
“Poly(ADP-ribose) Polymerase-1 Activity Facilitates the Dissociation of Nuclear Proteins from Platinum-Modified DNA.” Guggenheim, E. R.; Ondrus, A. E.; Movassaghi, M.; Lippard, S. J. Bioorg. Med. Chem. 2008, 16, 10121–10128.
“A Versatile Cyclodehydration Reaction for the Synthesis of Isoquinoline and Beta-Carboline Derivatives.” Movassaghi, M.; Hill, Matthew D. Org. Lett. 2008, 10, 3485–3488.
“New Strategies for the Synthesis of Hexahydropyrroloindole Alkaloids Inspired by Biosynthetic Hypotheses.” Schmidt, M. A.; Movassaghi, M. Synlett-(account) 2008, 313–324.
“Single-Step Synthesis of Alkynyl Imines from N-Vinyl and N-Aryl Amides. Synthesis of Phenyl-[1-phenyl-3-(trimethyl-silanyl)-prop-2-ynylidene]-amine.” Movassaghi, M.; Hill, M. D. Organic Syntheses 2008, 85, 88–95.
“New Strategies for the Synthesis of Pyrimidine Derivatives.” Hill, M. D.; Movassaghi, M. Chem. Eur. J. 2008, 14, 6836–6844.
“On the Interactions of N,N'-Bismesityl-imidazolin-2-yl and Alcohols.” Schmidt, M. A.; Movassaghi, M. Tetrahedron Lett. 2008, 49, 4316–4318.
“Observations on the Use of Microwave Irradiation in Azaheterocycle Synthesis.” Hill, M. D.; Movassaghi, M. Tetrahedron Lett. 2008, 49, 4286–4288.
“Benzenesulfonic Acid, 2-Nitro-(1-Methylethylidene)hydrazide.” Movassaghi M., Ahmad, O. K. e-Encyclopedia of Reagents for Organic Synthesis 2008.
“Direct Synthesis of Substituted Pyrimidines and Quinazolines.” Hill, M. D.; Movassaghi, M. Synthesis 2008, 823–827.
“Efficient and Stereoselective Dimerization of Pyrroloindolizine Derivatives Inspired by a Hypothesis for the Biosynthesis of Complex Myrmicarin Alkaloids.” Movassaghi, M.; Ondrus, A. E.; Chen, B. J. Org. Chem. 2007, 72, 10065–10074.
“Direct Synthesis of Pyridine Derivatives.” Movassaghi, M.; Hill, M. D.; Ahmad, O. K. J. Am. Chem. Soc. 2007, 129, 10096–10097.
“Synthesis of pyrimidines by direct condensation of amides and nitriles.” Movassaghi, M.; Hill, M. D. Nature Protocols 2007, 2, 2018-2023.
“Concise Total Synthesis of (–)-Calycanthine, (+)-Chimonanthine, and (+)-Folicanthine.” Movassaghi, M.; Schmidt, M. A. Angew. Chem. Int. Ed. 2007, 46, 3725–3728.
“N-Isopropylidene-N'-2-nitrobenzenesulfonyl Hydrazine, a Reagent for Reduction of Alcohols via the Corresponding Monoalkyl Diazenes."” Movassaghi, M.; Ahmad, O. K. J. Org Chem. 2007, 72, 1838–1841.
“Highly Stereoselective Intermolecular Formal [3+3] Cycloaddition Reaction of Cyclic Enamines and Enones.” Movassaghi, M.; Chen, B. Angew. Chem. Int. Ed. 2007, 46, 565–568.
“Synthesis of Optically Active Imidazopyridinium Salts and the Corresponding NHCs.” Schmidt, M. A.; Movassaghi, M. Tetrahedron Lett. 2007, 48, 101–104.
“Synthesis of Substituted Pyridines and Quinolines.” Hill, M. D.; Movassaghi, M. Synthesis 2007, 1115–1119.
“Single-Step Synthesis of Pyrimidine Derivatives.” Movassaghi, M.; Hill, M. D. J. Am. Chem. Soc. 2006, 128, 14254–14255.
“Total Synthesis and Absolute Stereochemical Assignment of (+)- and (–)-Galbulimima Alkaloid 13.” Movassaghi, M.; Hunt, D. K.; Tjandra, M. J. Am. Chem. Soc. 2006, 128, 8126–8127.
“Enantioselective Total Synthesis of (–)-Acylfulvene and (–)-Irofulven.” Movassaghi, M.; Piizzi, G.; Siegel, D. S.; Piersanti, G. Angew. Chem. Int. Ed. 2006, 45, 5859–5863.
“Synthesis of Substituted Pyridine Derivatives via the Ruthenium–Catalyzed Cycloisomerization of 3-Azadienynes.” Movassaghi, M.; Hill, M. D. J. Am. Chem. Soc. 2006, 128, 4592–4593.
“Dimerization of (+)-myrmicarin 215B. A potential biomimetic approach to complex myrmicarin alkaloids.” Ondrus, A. E.; Movassaghi, M. Tetrahedron, 2006, 62, 5287–5297.
“Enantioselective Total Synthesis of Tricyclic Myrmicarin Alkaloids.” Movassaghi, M.; Ondrus, A. E. Org. Lett. 2005, 7, 4423–3326.
“Palladium Catalyzed Synthesis of N-Vinyl Pyrroles and Indoles.” Movassaghi, M.; Ondrus, A. E. J. Org. Chem. 2005, 7, 8638–8641.
“N-Heterocyclic Carbene-Catalyzed Amidation of Unactivated Esters with Amino Alcohols.” Movassaghi, M.; Schmidt, M. A. Org. Lett. 2005 , 7, 2453–2456.
“o-Nitrobenzenesulfonylhydrazide.” Myers, A. G.; Movassaghi M. e-Encyclopedia of Reagents for Organic Synthesis 2003.
“A Direct Method for the Conversion of Terminal Epoxides into ?-Butanolides.” Movassaghi, M.; Jacobsen; E. N. J. Am. Chem. Soc. 2002, 124, 2456–2457.
“The Simplest Enzyme.” Movassaghi, M.; Jacobsen, E. N. Science 2002, 298, 1904–1905.
“Synthesis of Highly Epimerizable N-Protected ?-Amino Aldehydes of High Enantiomeric Excess.” Myers, A. G.; Zhong, B.; Movassaghi, M.; Kung, D. W.; Lanman, B. A.; Kwon, S. Tetrahedron Lett. 2000, 41, 1359–1362.
“Synthesis of C-Protected α-Amino Aldehydes of High Enantiomeric Excess from Highly Epimerizable N-Protected ?-Amino Aldehdyes.” Myers, A. G.; Zhong, B.; Kung, D. W.; Movassaghi, M.; Lanman, B. A.; Kwon, S. Org. Lett. 2000, 2, 3337–3340.
“Preparation of Chiral, C-Protected ?-Amino Aldehydes of High Optical Purity and Their Use as Condensation Components in a Linear Synthesis Strategy.” Myers, A. G.; Kung, D. W.; Zhong, B.; Movassaghi, M.; Kwon, S. J. Am. Chem. Soc. 1999, 121, 8401–8402.
“Highly Efficient Methodology for the Reductive Coupling of Aldehyde Tosylhydrazones with Alkyllithium Reagents.” Myers, A. G.; Movassaghi, M. J. Am. Chem. Soc. 1998, 120, 8891–8892.
“Single-Step Process for the Reductive Deoxygenation of Unhindered Alcohols.” Myers, A. G.; Movassaghi, M.; Zheng, B. J. Am. Chem. Soc. 1997, 119, 8572–8573.
“Mechanistic Studies of the Free-Radical Fragmentation of Monoalkyl Diazenes.” Myers, A. G.; Movassaghi, M.; Zheng, B. Tetrahedron Lett. 1997, 38, 6569–6572.
“Preparation of the Reagent o-Nitrobenzenesulfonlylhydrazide.” Myers, A. G.; Zheng, B.; Movassaghi, M. J. Org. Chem. 1997, 62, 7507.