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SAUER LAB BIOLOGY DEPARTMENT |
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SAUER LAB
BIOLOGY DEPARTMENT
Alumni (2022-2018)
(reverse listing - please scroll down)
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Xue Fei
Postdoc Fellow
February 2015-October 2021
Senior Scientist
Kymera Therapeutics
Sauer RT, Fei X, Bell TA, Baker TA. Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis. Crit Rev Biochem Mol Biol. 2022 Apr;57(2):188-204. doi: 10.1080/10409238.2021.1979461. Epub 2021 Dec 19. PMID: 34923891.
Baytshtok V, Fei X, Shih TT, Grant RA, Santos JC, Baker TA, Sauer RT. Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep. 2021 Jan 19;34(3):108639. doi: 10.1016/j.celrep.2020.108639. PMID: 33472065; PMCID: PMC7849044.
Fei X, Bell TA, Barkow SR, Baker TA, Sauer RT. Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Elife. 2020 Oct 22;9:e61496. doi: 10.7554/eLife.61496. PMID: 33089779; PMCID: PMC7652416..
Sanjay Hari
Postdoc Associate (2014-August 2015) and September 2017 - 2019
NIH Postdoc Fellow (September 2015-August 2017)
Senior Scientist
5AM Ventures
Hari, S.B., Grant, R.A. & Sauer, R.T. (2018) Structural and functional analysis of E. coli cyclopropane fatty acid synthase. Structure pii: S0969-2126(18)30214-4. doi: 10.1016/j.str.2018.06.008.
Amberg-Johnson, K., Hari, S.B, Ganesan, S.M, Lorenzi, H.A, Sauer, R.T, Niles, J.C, & Yeh, E. (2017) Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens. Elife 6.
Hari, S.B., and Sauer, R.T. (2016) The AAA+ FtsH Protease Degrades an ssrA-Tagged Model Protein in the Inner Membrane of Escherichia coli. Biochemistry Sep. 30 2016.
Erin Devine
Postdoc Associate (February 2016 -October 2018)
Senior Scientist
Mediar Therapeutics
Tristan Bell
Graduate Student (June 2016-2020)
Postdoctoral Researcher
Massachusetts General Hospital Research Institute
Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Fei X, Bell TA, Jenni S, Stinson BM, Baker TA, Harrison SC, Sauer RT. Elife. 2020 Feb 28;9:e52774. doi: 10.7554/eLife.52774. PMID: 32108573
Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Fei X, Bell TA, Barkow SR, Baker TA, Sauer RT. Elife. 2020 Oct 22;9:e61496. doi: 10.7554/eLife.61496. PMID: 33089779
ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP. Kim S, Zuromski KL, Bell TA, Sauer RT, Baker TA. Elife. 2020 Dec 1;9:e61451. doi: 10.7554/eLife.61451. PMID: 33258771
Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding. Bell TA, Baker TA, Sauer RT. Elife. 2019 Jun 28;8:e46808. doi: 10.7554/eLife.46808. PMID: 31251172
Hinge-Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity. Bell TA, Baker TA, Sauer RT. Biochemistry. 2018 Dec 11;57(49):6787-6796. doi: 10.1021/acs.biochem.8b00907. Epub 2018 Nov 20. PMID: 30418765
Curran Oi
Graduate Student - Exchange Scholar(March 2018 - August 2018)
Email curran.oi [at] yale.edu)
Yale University
