8.592 - HST.452J (Spring 2022)
Statistical Physics in Biology
Lecture 17
(Please note that lecture is being recorded)
8.592 in 4-265 on 03/28/2022 at 2:30PM
Microtubules
Filaments in the cycloskeleton
and their
function
:
Actin filaments
Structure
Treadmilling
and
regulation
Intermediate filaments
Microtubules
Video
Microtubule
structure:
Tubulin subunits
Protofilaments, nucleation and growth
Polarity
Dynamic Instability
[
Mitchison & Kirchner, Nature
312
, 237 (1984)
] (
video
)
Model of growth and regulation
(Leibler, et al) [
JCB
118
, 1097 (1992)
] [
PRL
70
, 1347 (1993).
]
Model of catastrophes [
H. Flyvbjerg, TE Holy, & S. Leibler, PRL
73
, 2372 (1994).
]
Search strategy
Mitosis
Condensation of RecA on ssDNA
as a tool for
computation by stochastic assembly
Relation to kinetic proof-reading
Fidelity of replication (Hopfield 74)
Self-organization of microtubules and motors in vitro
(
Lecture notes
)
Some related links
Nonosimulations of the cytoskeleton
(a PhD thesis by Christopher Betts)
8.592
lectures- last update 3/27/22 by M. Kardar