1. Haldane's equation for fixation of
• Near neutral mutations
• Weakly advantageous/deleterious mutations
2. Hallmarks of cancer:
• Driver mutations: oncogenes and tumor suppressors
• High mutation rates
• Passenger mutations
3. Model of tumor progression
• Target spaces for drivers/passengers
• Population size from logistic map
• Punctuated growth due to mutations

(Slides from Mirny)

(Mirny Lecture Notes)

(Kardar Lecture Notes)