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Publications

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Recent Publications (2017 - 2018)

2018

  1. Kauffman, Kevin, Oberli, M., Dorkin, J. R., Hurtado, J., Kaczmarek, J., Bhadani, S., Wycokoff, J., Langer, R., Jaklenec, A. and Anderson, D., Rapid single cell analysis and discovery of vectored mRNA transfection in vivo and with a loxP-flanked tdTomato reporter mouse, Molecular Therapy Nucleic Acids, 10:  55-63, 2018.
  2. Mikulskis, P., Hook, A., Dundas, A., Irvine, D., Sanni, O., Anderson, D., Langer, R., Alexander, M., Williams, P., Winkler, D. Prediction of broad-spectrum pathogen attachment to coating materials for biomedical devices, ACS Applied Materials and Interfaces, 10: 139-149, 2018.
  3. Tong, Z., Martyn, K., Yang, A., Yin, X., Mead, B., Joshi, N., Sherman, N., Langer, R. and Karp, J., Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells, Biomaterials, 154:  60-73, 2018.
  4. Bisso, P, Tai, M, Katepalli, H, Bertrand, N, Blankschtein, D, Langer, R, Molecular rotors for universal quantitation of nanoscale hydrophobic interfaces in microplate format, Nano Letters, 18:  618-628, 2018.
  5. Chertok, B. and Langer, R., Circulating magnetic microbubbles for localized real time control of drug delivery by ultrasonography guided magnetic targeting and ultrasound, Theranostics, 8: 341, 2018.
  6. Kirtane, A, Abouzid, O, Minahan, D, Bensel, T,  Hill, A.L, Selinger, C, Bershteyn, A, Craig, M, Mo, S.S, Mazdiyasni, H, Cleveland, C, Rogner, J, Lee, Y-A L, Booth, L, Javid, F, Wu, S, Grant, G, Bellinger, A, Nikolic, B, Hayward, A, Wood, L, Eckhoff, P.A., Nowak, M, Langer, R, Traverso, G, Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy, Nature Communications, 9: 2, DOI:10.1038/s41467-017-02294-6, 2018.
  7. Mahmoudi, M., Yu, M., Serpooshan, V., Wu, J., Langer, R., Lee, R., Karp, J. and Farokhzad, O, Multiscale technologies for treatment of ischemic cardiomyopathy, Nature Nanotechnology, in press.
  8. Kakkar, A., Traverso, G., Farokhzad, O., Weissleder, R. and Langer, R., Evolution of macromolecular complexity in drug delivery systems, Nature Reviews Chemistry, in press.
  9. Aday, S., Zoldan, J., Besnier, M., Carreto, L., Saif, J., Fernandes, R., Santos, T., Bernardino, L., Langer, R., Emanueli, C. and Ferreira, L., Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition, Nature Communications, in press.
  10. Jung, K., Heishi, T., Khan, O., Kowalski, P., Incio, J., Rahbari, N., Chung, E., Clark, J., Willett, Luster, A., Yun, S., Langer, R., Anderson, D., Padera, T., Jain, R. and Fukumura, D., Ly6C(low) monocytes drive immunosuppression and confer resistance to anti-VEGFR2 therapy in colorectal cancer, Journal of Clinical Investigation, in press.
  11. Dagdeviren, C, Ramadi, K, Joe, P, Spencer, K, Schwerdt, H, Shimazu, H, Delcasso, S, Amemori, K-I, Lopez, C, Graybiel, A, Cima, M, Langer, R, Regulation of brain activity by a miniaturized neural drug delivery system, Science Translational Medicine, in press.
  12. McHugh, K, Jing, L, Behrens, A, Jayawardena, S, Tang, W, Gao, M, Langer, R, Jaklenec, A, Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents, Advanced Materials, in press.
  13. Kauffman, K, Oberli, M, Dorkin, JH, Kaczmarek, J, Bhadani, S, Wyckoff, J, Langer, R, Jaklenec, A, Anderson, D, Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection in vivo with a loxP Flanked tdTomato Reporter Mouse, Molecular Therapy - Nucleic Acids, submitted.
  14. Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences, submitted.
  15. Jaklenec, A., Guarecuco, R., Lu, J., McHugh, K., Norman, J., Thapa, L., Lydon, E. and Langer, R., Immunogenicity of pulsatile release PLGA microspheres for single injection vaccination, Journal of Controlled Release, submitted.
  16. Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.
  17. DiCiccio, A., Lee, Y., Glettig, D., Walton, E., de La Serna, E., Montgomery, V., Grant, T., Langer, R. and Traverso, G., Caffeine-catalyzed gels, Advanced Materials, submitted.
  18. Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.
  19. Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.
  20. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., Overcoming pancreatic cancer chemoresistance with a locally directed biodegradable sustained drug delivery device, Gastroenterology, submitted.
  21. Fenton, O., Kauffman, K., McClellan, R., Appel, E., Dorkin, J., Tibbitt, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery, Journal of the American Chemical Society, submitted.
  22. Chauhan, V., Chen, I., Tong, R., Ng, M., Martin, J., Naxerova, K., Wu, M., Boucher, Y., Kohane, D., Langer, R., and Jain, R., Tumor microenvironment activated angiotensin blockers enhance cancer immunotherapy, Nature Nanotechnology, submitted.
  23. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., A local drug delivery platform to enhance cytotoxic effects of chemotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, submitted.
  24. Lin, J., Dargazany, R., Zhang, S., Jafari, M., Lee, Y., Hurowitz, H., Langer, R. and Traverso, G., Corona molecular dynamics of poly(ethylene glycol)-coated nanoparticles, Nano Letters, submitted.
  25. Yesilyurt, V., Veiseh, O., Doloff, J., Li, J., Bose, S., Xie, X., Bader, A., Chen, M., Webber, M., Vegas, A., Langer, R. and Anderson, D., A facile and versatile method to endow biomaterial devices with zwitterionic surface coatings, Journal of the American Chemical Society, submitted.
  26. Ragelle, H., Tibbitt, M., Wu, S., Castillo, M., Cheng, G., Gangadharan, S., Anderson, D., Cima, M. and Langer, R., Surface tension-assisted additive manufacturing, Nature Biomedical Engineering, submitted.
  27. Xie, X., Doloff, J., Sadraei, A., McGarrigle, J., Omani, M., Yesilyurt, V., Wang, W., Isa, D., Ghani, S., Joshi, I., Tam, H., Tao, J., Chen, H., Yang, B., Oberholzer, J., Langer, R. and Anderson, D., Elimination of continuous glucose monitor noise with zwitterionic polymer coating, Nature Biotechnology, submitted.
  28. Langer, R. and Traverso, G., Convergence for translation, Angewandte Chemie, submitted.
  29. Mikulskis, P, Hook, A, Dundas, A, Irvine, D, Sanni, O, Anderson, D, Langer, R, Alexander, M, Williams, P, Winkler, D, Prediction of Broad-spectrum Pathogen Attachment to Coating Materials for Biomedical Devices, ACS Applied Materials & Interfaces, submitted.
  30. Borenstein, J, Ayoob, A, Peppi, M, Tandon, V, Langer R, A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery, Hearing Research, submitted.

2017

  1. Spencer, K., Sy, J., Ramadi, K., Graybiel, A., Langer, R. and Cima, M., Characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants, Scientific Reports, 7: 1952: DOI:  10.1038/s41598-017-02107-2, 2017.
  2. Abid, A., O’Brien, J., Bensel, T., Cleveland, C., Booth, L., Smith, B., Langer, R., and Traverso, G., Wireless power transfer to millimeter sized gastrointestinal electronics validated in a swine model, Scientific Reports, 7: 46745: DOI:  doi:10.1038/srep46745, 2017.
  3. Delcassian, D., Elgueta, E., Ortiz, C., Bochenek, M., Qatachi, O., Chan, C., McGladrigan, C., Hausser, R. Langer, Anderson, D. and Shakesheff, K., Protecting transplanted cell therapies using immunomodulatory materials, Tissue Engineering, Part A., 23: S20, 2017.
  4. Doloff, J., Veiseh, O., Vegas, A., Tam, H., Farah, S., Ma, M., Li, J., Bader, A., Chiu, A., Sadraei, A., Aresta-DaSilva, S., Griffin, M., Jhunjhunwala, S., Webber, M., Siebert, S., Tang, K., Chen, M., Langan, E., Dholokia, N., Thakrar, R., Qi, M., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Colony stimulating factor-1 receptor is a central component of foreign body response to biomaterial implants in rodents and non-human primates, Nature Materials, |DOI: 10.1038/nmat4866, 2017.
  5. Mitchell, M., Webster, J., Chung, A., Guimaraes, P., Khan, O. and Langer, R., Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis, Nature Communications, 8:  DOI:10.1038/ncomms14179, 2017.
  6. Dahlman, J., Kauffman, K., Xing, Y., Shaw, T., Dlott, C., Mir, F., Langer, R., Anderson, D. and Wang, E., Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics, Proceedings of the National Academy of Sciences, 114:  2060-2065, 2017.
  7. Kim, K., Cha, Y., Han, M., Cha, H., Zoldan, J., Burkart, A., Jung, J., Jang, Y., Kim, C., Jeong, H., Kim, B., Langer, R., Kahn, C. and Guarente, L., Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis, Nature Cell Biology, 19:  445-456, 2017.
  8. Ragelle, H., Naba, A., Larson, B., Zhou, F., Prijic, M., Whittaker, C., Del Rosario, A., Langer, R., Hynes, R. and Anderson, D., Comprehensive proteomic characterization of stem cell-derived extracellular matrices, Biomaterials, 128:  147-159, 2017.
  9. Fay, F., Hansen, L., Hectors, S., Sanchez-Gaytan, B., Zhao, Y., Tang, J., Munitz, J., Alaarg, A., Braza, M., Gianella, A., Aaronson, S., Reiner, T., Kjems, J., Langer, R., Hoeben, F., Janssen, H., Calcagno, C., Strijkers, G., Fayad, Z., Perez-Medina, C. and Mulder, W., Investingating the cellular specificity in tumors of a surface-converting nanoparticle by multimodal imaging, Bioconjugate Chemistry, i28:  1413-1421, 2017.
  10. Slotkin, J., Pritchard, C., Luque, B., Ye, J., Layer, r., Lawrence, M., O’Shea, T., Roy, R., Zhong, H., Vollenweider, I., Edgerton, V., Courtine, G., Woodard, E. and Langer, R., Biodegradable scaffolds promote tissue remodeling and fuctional improvement in non-human primates with acute spinal cord injury, Biomaterials, 123:  63-76, 2017.
  11. Schoellhammer, C., Lauwers, G., Goettel, J., Oberli, M., Cleveland, C., Park, J., Minahan, D., Chen, Y., Anderson, D., Jaklenec, A., Snapper, S., Langer, R. and Traverso, G., Ultrasound-mediated delivery of RNA to colonic mucosa of live mice, Gastroenterology, 152:  1151-1160, 2017.
  12. Oberli, M., Reichmuth, A., Dorkin, J., Mitchell, M., Fenton, O., Jaklenec, A., Anderson, D., Langer, R. and Blankschtein, D., Lipid nanoparticle-assisted mRNA delivery for potent cancer immunotherapy, Nano Letters, 17:  1326-1335, 2017.
  13. Giwa, S., Lewis, J., Alvarez, L., Langer, R., Roth, A., Church, G., Markmann, J., Sachs, D., Chandraker, A., Wertheim, J., Rothblatt, M., Boyden, E., Eidbo, E., Lee, W., Pomahac, B., Brandacher, g., Weinstock, D., Elliott, G., Nelson, D., Acker, J., Uygun, K., Schmalz, B., Weegman, B., Tocchio, A., Fahy, G., Storey, K., Rubinsky, B., Bishof, J., Elliott, J., Woodruff, T., Morris, J., Demirci, U., Brockbank, K., Woods, E., Ben, R., Baust, J., Gao, D., Fuller, B., Rabin, Y., Kravitz, D., Taylor, M., and Toner, M., The promise of organ and tissue preservation to transform medicine, Nature Communications, 35:  530-542, 2017.
  14. Zhang, S., Langer, R., Traverso, G., Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease, 16:  Nano Today, 82-96, 2017.
  15. Tibbitt, M. and Langer, R., Living biomaterials, Accounts in Chemical Research, 50:  508-513, 2017.
  16. Polat, B., Schoellhammer, C., Langer, R. and Blankschtein, D., Combined use of ultrasound and other physical methods of Skin penetration enhancement, in Percutaneous Penetration Enhancers:  Physical Methods in Penetration Enhancement, pp. 369-377, 2017, eds: Dragicevic, N. and Maibach, H., Springer Link.
  17. Roper, J., Tammela, T., Cetinbas, N., Akkad, a., Roghanian, A., Rickelt, S., Almeqdadi, M., Wu, K., Oberli, M., Sanchez-Rivera, F., Park, Y., Liang, x., Eng., G., Taylor, M., Azimi, R., Kedrin, D., Neupane, R., Beyaz, S., Sicinska, E., Suarez, Y., Yoo, J., Chen, L., Zuckerbert, L., Katajisto, P., Deshpande, V., Bass, A., Tsichlis, P., Lees, J., Langer, R., Hynes, R., Chen, J., Bhutkar, A., Jacks, T. and Yilmaz, O., In vivo genome editing and orthotopic transplantation models of colorectal cancer and metastasis, Nature Medicine, 35:  569-579,2017.
  18. Rwei, A., Langer, R. and Kohane, D. Ultrasound-triggered local anaesthesia, Nature Biomedical Engineering, 1:  644-653, 2017.
  19. Langer, R., Advances in chemistry and their implications for studying and treating brain disease, Molecular Frontiers Journal, 1:  2-9, 2017.
  20. Zwang, Y., Jonas, O., Chen, C., Rinne, M., Doench, J., Piccioni, F., Tan, L., Huang, H., Wang, J., Ham, Y., O’Connell, J., Bhola, P., Doshi, M., Whitman, M., Cima, M., Letai, A., Root, D., Langer, R. Gray, N. and Hahn, C., Synergistic interactions with PI3K inhibition that induce apoptosis, eLife, 6:  e24523, 2017.
  21. Nadeau, P., El-Damak, D., Glettig, D., Kong, Y., Mo, S., Cleveland, C., Booth, L., Roxhed, N., Langer, R., Chandrakasan, A. and Traverso, G., Prolonged energy harvesting for ingestible devices, Nature Biomedical Engineering, E-pub ahead of time, DOI: 10.1038/s41551-016-0022, 2017.
  22. Yu, D., Khan, O., Suva, M., Dong, B., Panek, W., Xiao, T., Wu, M. Han, Y., Ahmed, A., Balyasnikova, I., Zhang, H., Sun, C., Langer, R., Anderson, D., Lesniak, M., Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression, Proceedings of the National Academy of Sciences, E-pub ahead of time, DOI:  10.1073/pnas.1701911114, 2017.
  23. Fenton, O., Kauffman, K., Kaczmarek, J., McClellan, R., Jhunjhunwala, S., Tibbitt, M., Zeng, M., Appel, E., Dorkin, J., Mir, F., Yang, J., Oberli, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes, Advanced Materials, DOI:  10.1002/adma.201606944, 2017.
  24. Liu, J., Pang, Y., Zhang, S., Cleveland, C., Yin, X., Booth, L., Lin, J., Lee, Y., Mazdiyasni, H., Saxton, S., Kirtane, A., von Erlach, T., Rogner, J., Langer, R. and Traverso, G., Triggerable tough hydrogels for gastric resident dosage forms, Nature Communications, 8: 124: DOI:  10.1038/s41467-017-00144-z, 2017.
  25. McHugh, K., Nguyen, T., Linehan, A., Yang, D., Behrens, A., Rose, S., Tochka, Z., Tzeng, S., Norman, J., Anselmo, A., Xu, X., Tomasic, S., Taylor, M., Lu, J., Guarecuco, R., Langer, R. and Jaklenec, A., Fabrication of fillable microparticles and other complex 3D microstructures, Science, 357:  1138-1142, 2017.
  26. Bakh, N., Cortinas, A., Weiss, M. Langer, R., Anderson, D., Gu, Z., Dutta, S. and Strano, M., Glucose responsive insulin by molecular and physical design, Nature Chemistry, 937–943, 2017.
  27. Abramson, A., Langer, R., Traverso, G, and Caffarel-Salvador, E., Oral delivery of biologics using drug-device combinations, Current Opinion in Pharmacology, 8-13, 2017.
  28.  Dagdeviren, C, Javid, F, Joe, P, von Erlach, Bensel, T, Wei, Z, Saxton, S, Cleveland, C, Booth, L, McDonnell, S, Collins, J, Hayward, A, Langer, R, Traverso, G, Flexible piezoelectric devices for gastrointestinal motility sensing, Nature Biomedical Engineering 1, 807-817, 2017.
  29. Mitchell, M., Jain, R. and Langer, R., Engineering and physical sciences in oncology:  Challenges and opportunities, Nature Reviews Cancer, 659-675, 2017.
  30. Yin, H, Song, C-Q, Suresh, S, Wu, Q, Walsh, S, Rhym, L.H., Mintzer, E, Bolukbasi, M.F., Zhu, L.J., Kauffman, K, Mou, H, Oberholzer, A, Ding, J, Kwan, S-Y, Bogorad, R, Zatsepin, T, Koteliansky, V, Wolfe, S.A., Xue, W, Langer, R, Anderson, D.G., Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Nature Biotechnology, 35:  1179-1187, 2017.
  31. Schoellhammer, C., Chen, Y., Cleveland, C., Minahan, D., Bensel, T., Park, J., Saxton, S., Lee, Y., Booth., L., Langer, R. and Traverso, G., Defining optimal permeant characteristics for ultrasound mediated gastrointestinal delivery, Journal of Controlled Release, 268:  113-119, 2017.
  32. Schwerdt, H., Shimazu, H., Amemori, K., Amemori, S., Tierney, P., Gibson, D., Hong, S., Yoshida, T., Langer, R., Cima, M. and Graybiel, A., Long-term dopamine neurochemical monitoring in primates, Proceedings of the National Academy of Sciences, 14:  13260-13265, 2017.
  33. Bertrand, N., Grenier, P., Mahmoudi, M., Lima, E., Appel, E., Dormont, F., Lim, J., Karnik, R., Langer, R. and Farokhzad, O., Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics, Nature Communications, 8:  77, 2017.

 

Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: July 9, 2018