Kreyòl

DNA Glycosylase

• Explore the relationship between a protein’s structure and its function in a human DNA glycosylase called human 8-oxoguanine glycosylase (hOGG1).

Hemoglobin & Sickle Cell Anemia

• Explore how a single alteration in the amino acid sequence of the hemoglobin protein results in sickle cell anemia, a genetically-inherited blood disorder.

Macromolecules

• This exercise explores the four main classes of organic macromolecules found in living things, .

Phenylalanine Hydroxylase & PKU Disorder

• Explore • the relationship between the structure of a mutated form of PAH and the function of this mutated protein in patients with phenylketonuria (PKU), a genetically inherited disorder that is characterized by the inability to utilize the essential amino acid, phenylalanine.

Phosphofructokinase (PFK)

• Explore the structure and function of the enzyme phosphofructokinase (PFK), the most important regularoty enzyme of glycolysis.

Ras and Cell Signaling

• Ras proteins are essential components of various signal transduction pathways that regulate growth, proliferation, differentiation, and apoptosis. In this exercise you will explore the structure of the Ras protein in its active and inactive states and the amino acids that contribute to these two states.