Welcome to the Baker Lab at MIT -
Our goal is to understand the mechanism
and regulation of two
classes of macromolecular machines: the Clp/Hsp100 ATPases that catalyze protein unfolding and the disassembly of protein complexes, and the tranposase/integrase family of recombinases that catalyze DNA transposition. These biological catalysts are being studied using biochemistry, structural biology, molecular biology, and genetics.