Acylsilanes
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Synthesis and Chemistry of Acysilanes

Our research in this area has involved the development of new methods for the synthesis of acylsilanes, as well as their application in organic synthesis. A principal focus of our work has been the chemistry of functionalized acylsilane derivatives, including a,b-unsaturated acylsilanes, cyclopropylacylsilanes, and a-halo, a-phosphono, and a-sulfonium acylsilanes.

References:

"Conjugate Addition of Allylsilanes to a,b-Unsaturated Acylsilanes", R. L. Danheiser and D. M. Fink, Tetrahedron Lett. 1985, 26, 2509.
 

"The Reaction of Allenysilanes with a,b-Unsaturated Acylsilanes: New Annulation Approaches to Five and Six-Membered Carbocyclic Compounds", R. L. Danheiser and

D. M. Fink, Tetrahedron Lett. 1985, 26, 2513.

"A Practical and Efficient Synthesis of a,b-Unsaturated Acylsilanes", R. L. Danheiser, D. M. Fink, K. Okano, Y. -M. Tsai, and S. W. Szczepanski, J. Org. Chem. 1985, 50, 5393.

"(l-Oxo-2-propenyl)trimethylsilane", R. L. Danheiser, D. M. Fink, K. Okano, Y. -M. Tsai, and S. W. Szczepanski, Organic Syntheses 1988, 66, 14.

 "Chemistry of Cyclopropylacylsilanes I. a-Functionalized Acylsilane Reagents for the Cyclopropanation of Electrophilic Alkenes", J. S. Nowick and R. L. Danheiser, Tetrahedron 1988, 44, 4113.

"Application of a-Phosphonoacylsilane Reagents to the Synthesis of a,b-Unsaturated Acylsilanes", J. S. Nowick and R. L. Danheiser, J. Org. Chem. 1989, 54, 2798.

[ Home ] [ [2 + 2 + 2] Cycloaddition Strategies ] [ [3 + 2] Annulations of Organosilanes ] [ Vinylcyclopropane Rearrangements ] [ Cycloadditions and Annulations of Vinylketenes ] [ Highly Unsaturated, Conjugated Molecules ] [ [4 + 2] Cycloadditions of Imine Derivatives ] [ Ketene [2 + 2] Cycloadditions ] [ Acylsilanes ] [ B-Lactones ] [ Cyclopropylboranes ] [ Allenylsilanes and Homopropargylic Alcohols ] [ Cationic Cyclizations ] [ Synthesis of Azulenes ] [ Miscellaneous Synthetic Methods ]

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Last modified: June 23, 2012