1. Arnold, K.B., A. Burgener, K. Birse, L. Romas, L.J. Dunphy, K. Shahabi, M. Abou, G.R. Westmacott, S. McCorrister, J. Kwatampora, B. Nyanga, J. Kimani, L. Masson, L.J. Liebenberg, S.S. Abdool Karim, J.S. Passmore, D.A. Lauffenburger, R. Kaul, L.R. McKinnon, “Increased Levels of Inflammatory Cytokines in the Female Reproductive Tract are Associated with Altered Expression of Proteases, Mucosal Barrier Proteins, and an Influx of HIV-Susceptible Target Cells”, Mucosal Immunol. 9: 194-205 (2016).
  2. Ip, B., N. Cilfone, A.C. Belkina, J. DeFuria, M. Jagannathan-Bogdan, M. Zhu, R. Kuchibhatla, M.E. McDonnell, Q. Xiao, T.B. Kepler, C.M. Apovian, D.A. Lauffenburger, and B.S. Nikolajczyk, “Th17 Cytokines and Downstream TNFa Production Impact Inflammation in Human Type 2 Diabetes&rduo;, Obesity 24: 102-112 (2016).
  3. Gordonov, S., M.K. Hwang, A. Wells, F.B. Gertler, D.A. Lauffenburger, and M. Bathe, “Time-Series Modeling of Live-Cell Shape Dynamics for Image-Based Phenotypic Profiling”, Integr. Biol. 8: 73-90 (2016).
  4. Oudin, M.J., S.K. Hughes, N. Rohani, M.N. Moufarrej, J.G. Jones, J.S. Condeelis, D.A. Lauffenburger, F.B. Gertler, “Characterization of the Expression of the Pro-Metastatic MenaINV Isoform during Breast Tumor Progression”, Clin. Exp. Metastasis 33: 249-261 (2016).
  5. Oudin, M.J., O. Jonas, T. Kosciuk, A. Riching, L.C. Broye, J. Wyckoff, S.K. Hughes, J.M. Lamar, S.B. Asokan, R. Langer, D.A. Lauffenburger, P. Keely, J.E. Bear, and F.B. Gertler, “MenaINV-Mediated Bi-Directional Signaling through a5b1 Integrin Supports Tumor Cell Haptotaxis and ECM Remodeling During Metastsis”, Canc. Disc. 6: 516-531 (2016).
  6. Archary, D., K.E. Seaton, J.S. Passmore, L. Werner, A. Deal, L.J. Dunphy, K.B. Arnold, N.L. Yates, D.A. Lauffenburger, P. Bergin, L.J. Liebenberg, N. Samsunder, M.W. Mureithi, M. Altfeld, N. Garrett, Q. Abdool Karim, S. Abdool Karim, L. Morris, and G.D. Tomaras, “Distinct Genital Tract HIV-Specific Antibody Profiles Associated with Tenofovir Gel”, Mucosal Immunol. 9: 834 (2016).
  7. Zhao, B., J.C. Sedlak, R. Srinivas, P. Creixell, J.R. Pritchard, B. Tidor, D.A. Lauffenburger, and M.T. Hemann, “Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution”, Cell 165: 234-246 (2016).
  8. Miller, M.A., M.J. Oudin, R.J. Sullivan, S.J. Wang, A.S. Meyer, H. Im, D.T. Frederick, J. Tadros, L.G. Griffith, H. Lee, R. Weissleder, K.T. Flaherty, F.B. Gertler, and D.A. Lauffenburger, “Reduced Proteolytic Shedding of Receptor Tyrosine Kinases is a Post-Translational Mechanism of Kinase Inhibitor Resistance”, Canc. Disc. 6: 382-399 (2016).
  9. Tape, C.J., S. Ling, M. Dimitriadi, K.M. McMahon, J.D. Worboys, H.S. Leong, I.C. Norrie, C.J. Miller, G. Poulogiannis, D.A. Lauffenburger, and C. Jorgensen, “Oncogenic K-Ras Regulates Tumor Cell Signaling via Stromal Reciprocation”, Cell 165: 1818 (2016).
  10. Chitforoushzadeh, Z., Z. Ye, Z. Sheng, S. LaRue, R.C. Fry, D.A. Lauffenburger, and K.A. Janes, “TNF-Insulin Crosstalk at the Transcription Factor GATA6 is Revealed by a Model that Links Signaling and Transcriptomic Data Tensors”, Sci. Signaling 9: ra59 (2016).
  11. Wilson, J.L., S. Dalin, S. Gosline, M. Hemann, E. Fraenkel, and D.A. Lauffenburger, “Pathway-Based Network Modeling finds Hidden Genes in shRNA Screen for Regulators of Acute Lymphoblastic Leukemia”, Integr. Biol. 8: 761-774 (2016).
  12. Zevin, A.S., I.Y. Xie, K. Birse, K. Arnold, L. Romas, G. Westmacott, R.M. Novak, S. McCorrister, L.R. McKinnon, C.R. Cohen, R. Mackelprang, J. Lingappa, D.A. Lauffenburger, N.R. Klatt, and A.D Burgener, “Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract”, PLoS Pathogens 12: e1005889 (2016).
  13. Oudin, M.J., M.A. Miller, J.A. Klazen, T. Kosciuk, A. Lussiez, S.K. Hughes, J. Tadros, J.E. Bear, D.A. Lauffenburger, and F.B. Gertler, “MenaINV Mediates Synergistic Crosstalk between Signaling Pathways driving Chemotaxis and Haptotaxis”, Molec. Biol. Cell (online, 2016).
  14. Schrier, S.B., A.S. Hill, D. Plana, and D.A. Lauffenburger, “Synergistic Communication Between CD4+ T Cells and Monocytes Impacts the Cytokine Environment”, Sci. Reports 6: 34942 (2016).
  15. Morris, M.K., D.C. Clarke, L.C. Osimiri, and D.A. Lauffenburger, “Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks”, CPT: Pharmacometrics & Systems Pharmacology 5: 544-553 (2016).
  16. Balsamo, M., C. Mondal, G. Carmona, L.M. McClain, D.N. Riquelme, J. Tadros, D. Ma, E. Vasile, J.S. Condeelis, D.A. Lauffenburger, and F.B. Gertler, “The Alternatively-Included 11a Sequence Modifies the Effects of Mena on Actin Cytoskeletal Organization and Cell Behavior”, Sci. Reports 6: 35298 (2016).
  17. Lu, L.L., A.W. Chung, T.R. Rosebrock, M. Ghebremichael, W.H. Yu, P.S. Grace, M.K. Schoen, F. Tafesse, C. Martin, V. Leung, A.E. Mahan, M. Sips, M.P. Kumar, J. Tedesco, H. Robinson, E. Tkachenko, M. Draghi, K.J. Freedberg, H. Streeck, T.J. Suscovich, D.A. Lauffenburger, B.I. Restrepo, C. Day, S.M. Fortune, and G. Alter, “A Functional Role for Antibodies in Tuberculosis”, Cell 167: 433-443 (2016).
  18. Nagel, Z.D., G.J. Kitange, S.K. Gupta, B.A. Joughin, I.A. Chaim, P. Mazzacuto, D.A. Lauffenburger, J.N. Sarkaria, and L.D. Samson, “DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme”, Cancer Res. 77: 198-206 (2016).
  19. Moynihan, K.D., C.F. Opel, G.L. Szeto, A. Tzeng, E.F. Zhu, J.M. Engreitz, R.T. Williams, K. Rakhra, M.H. Zhang, A.M. Rothschilds, S. Kumari, R.L. Kelly, B.H. Kwan, W. Abraham, K. Hu, N.K. Mehta, M.J. Krauke, H. Suh, J.R. Cochran, D.A. Lauffenburger, K.D. Wittrup, and D.J. Irvine, “Eradication of Large Established Tumors in Mice by Combination Immunotherapy that Engages Innate and Adaptive Immune Responses”, Nature Medicine 22: 1402-1410 (2016).
  20. Clark, A.M., S.E. Wheeler, C.L. Young, L. Stockdale, J. Shepard Neiman, W. Zhao, D.B. Stolz, R. Venkataramanan, D.A. Lauffenburger, L. Griffith, and A. Wells, “A Liver Microphysiological System of Tumor Cell Dormancy and Inflammatory Responsiveness is Affected by Scaffold Properties”, Lab on a Chip 17:156-168 (2016).
  21. Sun, D., S. Dalin, M.T. Hemann, D.A. Lauffenburger, and B. Zhao, “Differential Selective Pressure Alters Rate of Drug Resistance Acquisition in Heterogeneous Tumor Populations”, Sci. Reports 6: 36198 (2016).
  22. Oudin, M.J., L. Barbier, C. Schafer, T. Kosciuk, M.A. Miller, S. Han, O. Jonas, D.A. Lauffenburger, and F.B. Gertler, “Mena Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer”, Molec. Canc. Ther. 16: 143-155 (2017).
  23. Jones, D.S., A.P. Jenney, J.L. Swantek, J.M. Burke, D.A. Lauffenburger, and P.K. Sorger, “Profiling Drugs for Rheumatoid Arthritis that Inhibit Synovial Fibroblast Activation”, Nature Chem. Biol. 13: 38-45 (2017).
  24. Li, R., J.D. Hebert, T.A. Lee, H. Xing, A. Boussommier-Calleja, R.O. Hynes, D.A. Lauffenburger, and R.D. Kamm, “Macrophage-Secreted TNFa and TGFb1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways”, Cancer Res. 77: 279-290 (2017).
  25. Liebenberg, L.J., L. Masson, K.B. Arnold, L.R. McKinnon, L. Werner, E. Proctor, D. Archary, L.E. Mansoor, D.A. Lauffenburger, Q. Abdool Karim, S.S. Abdool Karim, and J.S. Passmore, “Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women”, J. AIDS (online, 2017).
  26. Tan, L. D. Gurbani, E.L. Weisberg, D.S. Jones, S. Rao, W.D. Singer, F.M. Bernard, S. Mowafy, A. Jenney, G. Du, A. Nonami, J.D. Griffith, D.A. Lauffenburger, K.D. Westover, P.K. Sorger, and N.S Gray, “Studies of TAK1-Centered Polypharmacology with Novel Covalent TAK1 Inhibitors”, Bioorg. Med. Chem. (online, 2017).
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