1992 - 1996 - Ph.D. in Chemistry, University of California Berkeley
2014 - present Professor, Department of Chemistry
Awards and Honors
2014 Günther Laukien Prize, Experimental NMR Conference
My research focuses on the development and applications of solid-state NMR spectroscopy to elucidate the structure and dynamics of membrane proteins and other biological molecules. We are particularly interested in the mechanistic structural biology of ion channels and curvature-inducing membrane proteins. Our research has elucidated 1) the drug binding site and inhibition mechanism of the influenza M2 protein and the proton conduction mechanism of this proton channel, 2) the membrane-bound oligomeric structure of ?-hairpin antimicrobial peptides and the mechanism with which these arginine-rich cationic peptides insert into lipid membranes against the free energy barrier, and 3) the conformational and dynamical changes of a channel-forming colicin during its insertion into the lipid membrane. We also investigate the structure of biomaterials such as plant cell walls.
To enable these biological studies, we develop a wide variety of solid-state NMR techniques, such as 1) multidimensional correlation techniques, computational methods and isotopic labeling strategies for resonance assignment of proteins, 2) anisotropic-isotropic correlation techniques to measure torsion angles, molecular motion, and chemical shift tensors, 3) long-range distance techniques, and 4) intermolecular correlation techniques to determine membrane protein depth of insertion and hydration.
Department of Chemistry