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Scientific abstracts from the lab:

Slind, J., Ganetzky, B. & Littleton, J.T. (2000) SNARE complex disassembly by NSF following synaptic vesicle fusion. Soc. of Neurosci. Abstracts 26:128.2.

Littleton, J.T., Vyas, B., Bai, J., Ganetzky, B. & Chapman, E.R. (2000) The C2B-domain of synaptotagmin is required for calcium-triggered exocytosis and SNARE clustering.  Mol. Biol. Cell 11:278.

Adolfsen B., Mikula, M. & Littleton J.T. (2001) Characterization of the Drosophila synaptotagmin family.  Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.18.

Yoshihara, M. & Littleton, J. T. (2001) Embryonic neuromuscular junction recordings suggest Synaptotagmin I is a calcium sensor for neurotransmitter release. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p63.

Guan, Z., Adolfsen, B., Wang, P. & Littleton, J.T. (2001) Seizure mutants and activity-regulated gene expression in Drosophila. Cold Spring Harbor Neurobiology of Drosophila Abstracts p.248.

 Montana, E.S. & Littleton, J.T. (2001) Genetic and molecular identification of novel syntaxin-interacting proteins. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.37.

Rieckhof, G.E., Yoshihara, M. & Littleton, J.T. (2001) Analysis of the role of the N-type calcium channel in synapse formation and function. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.50.

Guan, Z., Adolfsen, B. & Littleton, J.T. (2002) Microarray analysis of activity-regulated gene expression in the Drosophila nervous system. Boston Area Neuroscience Group Meeting, p. 23.

Rieckhof, G.E., Yoshihara, M. & Littleton, J.T. (2002) Analysis of the role of the N-type calcium channel in synapse formation and function. Boston Area Neuroscience Group Meeting, p. 24.

Guan, Z., Adolfsen, B. & Littleton, J.T. (2002) Activity-regulated gene expression in the Drosophila Nervous System.  Cold Spring Harbor Axon Guidance & Neural Plasticity Abstracts, p.84.

Montana, E.S. & Littleton, J.T. (2003) The Samba mutants: A model for muscle myopathy in Drosophila melanogaster. Soc. of Neurosci. Abstracts 80.10.

Adolfsen B., Yoshihara, M. &  Littleton J.T. (2003) Characterization of the Drosophila synaptotagmin family. Soc. of Neurosci. Abstracts 686.16.

Adolfsen, B. & Littleton, J. T. (2003) Molecular and genetic dissection of the function of the synaptotagmin family.  Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.48.

Guan, Z., Adolfsen, B. & Littleton, J.T. (2003) Activity-dependent regulation of gene expression in the Drosophila brain. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.69.

Lee, W.C.M., Yoshihara, M. & Littleton, J.T. (2003)  Neurodegeneration in a Drosophila model of Huntington’s Disease.  Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.128.

Montana, E.S. & Littleton, J.T. (2003) The Samba mutants reveal a conserved cellular response to muscle dysfunction. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p.164.

Ian Coyle, Young-Ho Koh, Wyan-Ching Mimi Lee, Jessica Slind, Tim Fergestad, J. Troy Littleton & Barry Ganetzky. (2003)  Nervous Wreck, an adapter protein that interacts with WASP, regulates synapse growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 51.

Saraswati, S., Wang, P. &  Littleton, J.T. (2003) A Drosophila Temperature-Sensitive Seizure Mutant in Phosphoglycerate kinase disrupts ATP generation and alters synaptic function. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 241.

Yoshihara, M., Adolfsen, B, Waddell, S, & Littleton J.T. (2003) Postsynaptic activity regulates presynaptic differentiation via a cAMP-dependent retrograde pathway. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 112.

Montana, E.S. & Littleton, J.T. (2004) Genetic analysis of the Drosophila ARC homolog, dARC1.  Soc. of Neurosci. Abstracts 512.16.

Lee, W.C.M & Littleton, J.T. (2004) Modeling Huntington’s Disease in Drosophila melanogaster. Soc. of Neurosci. Abstracts 564.8.

Adolfsen B., Yoshihara, M. & Littleton J.T. (2004) Genetic dissection of Synaptotagmin 4-dependent postsynaptic vesicle trafficking. Soc. of Neurosci. Abstracts 514.10.

Yoshihara, M., Adolfsen, B, & Littleton J.T. (2004) Postsynaptic activity regulates presynaptic differentiation and growth via a Synaptotagmin 4-dependent vesicle fusion and cAMP pathway. Cold Spring Harbor Channels, Receptors and Synapses Abstracts.

Adolfsen B., Yoshihara, M. &  Littleton J.T. (2004) Molecular and genetic dissection of the Drosophila synaptotagmin family. Cold Spring Harbor Channels, Receptors and Synapses Abstracts.

Yoshihara, M., Adolfsen, B, Galle, K., & Littleton J.T. (2005) Retrograde signaling by Synaptotagmin 4 induces enhanced presynaptic release and synapse-specific growth. Cold Spring Harbor Learning  & Memory Abstracts, p. 121.

Yoshihara, M., Adolfsen, B, Galle, K., & Littleton, J.T. (2005) Retrograde signaling through postsynaptic vesicular trafficking mediates synaptic plasticity and growth in Drosophila. UBC Synaptic Function and Plasticity Conference Abstracts P104, p. 32.

Adolfsen B., Yoshihara, M. & Littleton, J.T. (2005) Molecular and genetic dissection of the Drosophila Synaptotagmin family.  Packard Foundation Fellows Meeting, Monterey, California.

Barber, C., Adolfsen, B & Littleton, J.T. (2005) Activity-regulated expression of Synaptotagmin 4 in Drosophila. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 21.

Lee., W.C.M., Mediatore, J. & Littleton, J.T. (2005) Characterization of axonal transport defects in a Drosophila Huntingtion’s Disease model.  Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 137.

Mattaliano, M., Montana, E, Hodge, J.J.L., Littleton, J.T. & Griffith, L.C. (2005) Arc-like proteins are involved in the response to metabolic stress. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 8148. 

Yoshihara, M., Adolfsen, B. & Littleton, J.T. (2005) Calcium-regulated postsynaptic vesicle trafficking by Synaptotagmin 4 mediates synapse-specific plasticity. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 89.

Saraswati, S., Adolfsen, B. & Littleton, J.T. (2005) Synaptotagmins are not the calcium receptors for synaptic facilitation or asynchronous release in Drosophila. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 208.

Rodal, A.A., Pigneri, D., Yu, A., Rodal, R. & Littleton, J.T. (2005)  Cytoskeletal regulation of neuronal structure and function. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 204.

Guan, Z., Saraswati, S., Adolfsen, B. & Littleton, J.T. (2005) Activity-regulated gene expression in the Drosophila nervous system. Soc. for Neurosci. Abstracts, 500.14.

Yoshihara, M., Adolfsen, B, Galle, K., & Littleton, J.T. (2005) Retrograde signaling through postsynaptic vesicular trafficking mediates synaptic plasticity and growth in Drosophila. Soc. for Neurosci. Abstracts, 593.3.

Yoshihara, M., Adolfsen, B, & Littleton, J.T. (2005) Retrograde signaling by Synaptotagmin 4 induces enhanced presynaptic release and synapse-specific growth. Neurons and Sensory Systems Satellite Meeting, p. 20.

Littleton, J.T. & Lee, W.M. (2006) Axonal transport defects in a Drosophila model of Huntington’s Disease.  37^th Annual American Society for Neurochemistry Meeting, Journal of Neurochemistry, 96 (Suppl. 1), p. 143.

Guan, Z., Saraswati, S., Adolfsen, B. & Littleton, J.T. (2006) Activity-regulated gene expression in the Drosophila nervous system. 5^th Annual Picower-RIKEN Neuroscience Symposium.

Saraswati, S., Adolfsen, B. & Littleton, J.T. (2006) Synaptotagmins are not the calcium receptors for synaptic facilitation or asynchronous release in Drosophila. 5^th Annual Picower-RIKEN Neuroscience Symposium.

Yoshihara, M., Adolfsen, B, & Littleton, J.T. (2006) Retrograde signaling by Synaptotagmin 4 induces enhanced presynaptic release and synapse-specific growth. 5^th Annual Picower-RIKEN Neuroscience Symposium.

Rodal, A.A., Pigneri, D., Yu, A., Rodal, R. & Littleton, J.T. (2006) Cytoskeletal regulation of neuronal structure and function. Boston Neural Connections Symposium.

Saraswati, S., Adolfsen, B. & Littleton, J.T. (2006) Synaptotagmins are not the calcium receptors for synaptic facilitation or asynchronous release in Drosophila. Boston Neural Connections Symposium.

Yoshihara, M., Adolfsen, B, Barber, C. & Littleton, J.T. (2006) Retrograde signaling though postsynaptic vesicular trafficking mediates synaptic plasticity and growth. EMBO Conference on the Molecular and Developmental Biology of Drosophila, Kolymbari, Crete

Lee, W.C.M., & Littleton, J.T. (2006) Characterization of axonal transport defects in a Drosophila Huntington’s Disease model. Huntington’s Disease 2006 Meeting:  Changes, Advances and Good News, Abstract #117.

Kirsch, D.R., Saraswati, S., Littleton, J.T. & Stilwell, G.  (2006) Development of a novel high-throughput in vivo screen for antiepileptic drugs in Drosophila melanogaster. Soc. for Neurosci. Abstracts, 280.9.

Akten B., Galle K. & Littleton J.T. (2006), The role of vesicular trafficking in the Drosophila neuromuscular junction. RIKEN Retreat, Tokyo, Japan.

Schulte, J., Hong, P. & Littleton, J.T. (2006) A Huntington’s Disease primary cell culture assay system for RNAi and small molecule screening. RIKEN Retreat, Tokyo, Japan.

Barber, C.F. & Littleton, J.T. (2007) Activity-dependent induction of synaptotagmin 4 retrograde signaling regulates synaptic growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 25.

Barr, L.K., Quinn, W.G. & Littleton, J.T. (2007) Molecular pathways to anesthesia-resistant memory. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 26.

Saraswati, S., Adolfsen, B. & Littleton, J.T. (2007) Genetic dissection of the role of the synaptotagmin family in neurotransmitter release and synaptic plasticity. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 229.

 Huntwork, S.N. & Littleton, J.T. (2007) A complexin fusion clamp regulates spontaneous release and synaptic growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 94.

Rodal, A.A. & Littleton, J.T. (2007) NWK cooperates with CDC42 to regulate WSP-dependent actin assembly during synaptic growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 218.

Weiss, K. & Littleton, J.T. (2007) A genetic screen for modifiers of lethality and aggregation in a Drosophila Huntington’s Disease Model. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 276.

Schulte, J., Hong, P. & Littleton, J.T. (2007) A Huntington’s Disease primary cell culture assay system for RNAi and small molecule screening. Keystone Symposium.

Barr, L.K., Quinn, W.G. & Littleton, J.T. (2007) Molecular pathways to anesthesia-resistant memory. RIKEN Retreat, Tokyo, Japan.

Stevens, R.J. & Littleton, J.T. (2007) Characterization of Synaptogyrin function in Drosophila. RIKEN Retreat, Tokyo, Japan.

Schulte, J., Sepp, K., Hong, P. & Littleton, J.T. (2008) A Huntington’s Disease primary cell culture assay system for RNAi and small molecule screening. Hereditary Disease Foundation Meeting, Abstract# 55b.

Zhang, S., Feany, M.B., Saraswati, S., Littleton, J.T. & Perrimon, N. (2008) Drosophila huntingtin is required for long-term adult functioning and its inactivation affects the pathogenesis of a Huntington’s Disease model in Drosophila. Hereditary Disease Foundation Meeting, Abstract# 101.

Jorquera, R.A., Huntwork, S., & Littleton, J.T. (2009) The SNARE-binding protein complexin modulates the kinetics of neurotransmitter release and short-term synaptic plasticity. Biophysical Society Meeting Abstract #1373.

Barr, L.K. & Littleton (2009) A molecular analysis of Complexin and its role in regulating neurotransmitter release and synaptic growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 30.

Jorquera, R.A., Cho, R.W., Huntwork, S., Song, Y. & Littleton, J.T. (2009) Characterization of the role of Complexin and Synaptotagmin in synaptic function and plasticity. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 222.

Rodal, A.A., Blunk, A.D., Akbergenova, Y. & Littleton, J.T. (2009) Nervous wreck and sorting Nexin 16 regulate presynaptic endosomal membrane traffic controlling synaptic growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 229.

Weiss, K. & Littleton, J.T. (2009) Characterization of the role of Huntingtin in fast axonal transport. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 285.

Cho, R. Jorquera, R.A., Huntwork, S., Song, Y. & Littleton, J.T. (2009) Mechanisms of Complexin function as a synaptic vesicle fusion clamp. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 51.

Stevens, R.J., Akbergenova, Y. & Littleton, J.T. (2009) Characterization of Synaptogyrin function in Drosophila. Soc. for Neurosci. Abstracts, 420.7.

Jorquera, R.A., Cho, R.W., Huntwork, S., Song, Y. & Littleton, J.T. (2009) Genetic dissection of release states modulated by synaptotagmin and complexin. Soc. for Neurosci. Abstracts, 522.10.

Melom, J.E. & Littleton, J.T. (2009) A role for a K⁺-dependent Na⁺, Ca²⁺ exchanger in glial modulation of neuronal excitability. Soc. for Neurosci. Abstracts, 624.16.

Littleton, J.T., Barber, C.F., Jorquera, R.A., Melom, J.E. & Akbegenova, Y. (2009) Postsynaptic regulation of retrograde signaling by Synaptotagmin 4 modulates synaptic plasticity. Soc. for Neurosci. Abstracts, 721.16.

Litttleton, J.T. (2010) Regulation of synaptic growth signaling at the Drosophia neuromuscular junction. Int. J. Devl. Neuroscience 28, 645-646.

Jorquera, R.A. & Littleton, J.T. (2010) Complexin and Synaptotagmin synchronize vesicle fusion. Pew Scholars Program in Biomedical Sciences Abstracts.

Melom, J.E. & Littleton, J.T. (2010) Mutation of a glial-specific NCKX causes defects in glial calcium signaling and neuronal hyperexcitability. Cold Spring Harbor Glia in Health & Disease Abstracts.

Stevens, R.J., Akbergenova, Y., Jorquera, R.A. & Littleton, J.T. (2010) Genetic analysis of synaptogyrin’s role in the synaptic vesicle cycle. Soc. for Neurosci. Abstracts, 319.1.

Jorquera, R.A., Cho, R.W., Huntwork, S., Barr, L. & Littleton, J.T. (2010) Complexin and Synaptotagmin in synaptic function and plasticity. Biophysical Society Meeting Abstract #3543.

Jorquera, R.A., Huntwork, S. & Littleton, J.T. (2011) Complexin and Synaptotagmin genetically interact in vivo controlling the rates of spontaneous and nerve-evoked vesicle fusion. Biophysical Journal 100, 31a-32a.

Melom, J. & Littleton J.T. (2011) Regulation of glial calcium oscillations and seizure susceptibility by the NCKX Zydeco. GLIA 59, S111.

Cho, R. Jorquera, R.A., Buhl, L., Volfson, D. & Littleton, J.T. (2011) Compexin regulated spontaenous release mediates synaptic growth and activity-dependent synaptic plasticity at Drosophila synapses. Cold Spring Harbor Synapses: From Molecules to Circuits & Behavior.

Jorquera, R.A., Piccioli, Z., Melom, J.E., Akbergenova, Y., Cho, R.W. & Littleton, J.T. (2011) Calcium regulation of neurotransmitter release and retrograde signaling. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 259.

Blunk, A., Akbergenova, Y., Cho, R.W., Lee, J. & Littleton, J.T. (2011) Mutations in postsynaptic actin alter presynaptic active zone organization and synaptic growth. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 34.

Harris, K., Perrimon, N. & Littleton, J.T. (2011) Characterization of Synaptotagmin 4-dependent postsynaptic exocytosis. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 104.

Weiss, K. & Littleton, J.T. (2011) The role of Huntingtin in fast axonal transport. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 313.

Akbergenova, Y. & Littleton, J.T. (2011) Pathogenic Huntingtin induces synaptic morphology defects by disrupting local BMP signaling. Cold Spring Harbor Neurobiology of Drosophila Abstracts, p. 23.

Jorquera, R.A, Huntwork, & Littleton, J.T. (2011) Complexin and Synaptotagmin co-regulate synaptic vesicle function. Pew Scholars Program in Biomedical Sciences Abstracts.

Piccioli, Z.D. & Littleton, J. T. (2011) Mechanisms underlying rapid activity-dependent synaptic growth at Drosophila neuromuscular junctions. Soc. for Neurosci. Abstracts 231.11.

Bykhovskaia, M., Jogota, A., Zhorov, B. & Littleton, J.T. (2011) Molecular dynamics simulation of SNARE complex unzippering reveals structural elements that may be critical for fusion clamping. Soc. for Neurosci. Abstracts 446.26.

Vasin, A., Littleton, J.T. & Bykhovskaia, M. (2011) Syntaxin 1A single point mutation compromises synaptic vesicle recycling. Soc. for Neurosci. Abstracts 446.26.

Lee, J., Guan, Z., Akbergenova, Y. & Littleton, J.T. (2011) Cooperativity between the tandem C2 domains of synaptotagmin 1 in evoked and spontaneous neurotransmitter release. Soc. for Neurosci. Abstracts 445.08.

Harris, K., Perrimon, N. & Littleton, J.T. (2012) A genetic screen for regulators of Synaptotagmin 4-dependent postsynaptic exocytosis. Soc. for Neurosci. Abstracts 683.11.

Blunk, A., Akbergenova, Y., Cho, R.W., Lee, J. & Littleton, J.T. (2012) Postsynaptic actin alter regulates presynaptic active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction. Soc. for Neurosci. Abstracts 743.05.

Cho, R.W., Barr-Buhl, L., Volfson, D. & Littleton, J.T. (2012) Regulation of Complexin function modulates activity-dependent growth of Drosophila synapses. Soc. for Neurosci. Abstracts 145.14.