| Family | Zebrafish Gene | Phenotypic Description | Image #1 | Image #2 | Image #3 | Image #4 |
|---|
| hi3635 | topoisomerase 2 | day1: cns necrosis; day 2: cns necrosis, rounder yolk with thin extension, thin body (sometimes bent up); days 3-5 progressively more necrotic head and thin/wasting body, develops pericardial edema, usually dead by day 5 |  |  | | |
| hi3639 | RNA polymerase I 194 kDa subunit | early day 1: cns necrosis, flat head; late day 1: less cns necrosis, thin midbrain/hindbrain boundary; day 2: smaller head and eyes, thin body, grey round yolk with thin extension; most dead by day 5 |  |  | | |
| hi3655b | 60S ribosomal protein L6 | day 2: slightly inflated hindbrain, slightly smaller head and eyes, thin yolk extension; day 3: slightly smaller head and eyes, rounder yolk with thin extension; day 5: (note - VARIABLE) smaller/rounder head, sometimes with pericardial edema, underdeveloped liver and gut - BUT can be more severe: smaller head and eyes, rounder yolk, thinner body |  |  | | |
| hi3662 | novel (D13S106E-like) | day 1: cns necrosis, slightly flat head; day 2 very bad necrosis in head, round grey yolk with thin extension, body curved up; most dead by day 5 |  |  | | |
| hi3663 | eukaryotic translation initiation factor 3 subunit 4 | day 2: small head and eyes, rounder yolk with thin extension, thin body and less pigment (like delay); day 3: small head and eyes, thin body, round grey yolk with thin extension; days 4-5 progressively more necrotic head and thin/wasting body, develops pericardial edema, usually dead by day 5 |  |  | | |
| hi3681 | v-ATPase membrane sector associated protein M8-9 | day 2: no pigment, slightly smaller head and eyes; day 5: still no pigment, a little cns necrosis, slightly smaller head, eyes, and ears, a little pericardial edema, underdeveloped liver/gut |  |  | | |
| hi3685 | RNA polymerase II subunit G | day 1: cns necrosis, slightly flat head; day 2: very small head and eye, thin body, pale, pericardial edema denting yolk, thin yolk extension; day 5: very small head and eyes, pericardial edema, thin/wasted body, often dead |  |  | | |
| hi3721 | DNA methyltransferase 1-associated protein 1 | day 5: narrow head, smaller eyes, slightly underdeveloped gut, sometimes trunk curved a bit ventrally |  | | | |
| hi3764 | novel (C21orf59-like) | day 2: trunk bent ventrally; day 5: body kinked over yolk and trunk bent ventrally, underdeveloped gut |  |  | | |
| hi3773 | novel (DKFZP564C186-like) | days 2-3: a bit smaller head and eyes, slightly rounder yolk (this is variable; sometimes cannot tell); day 5: small head and eyes, sometimes a bit of pericardial edema (variable), slightly underdeveloped liver/gut |  | | | |
| hi3785 | gamma tubulin | day 4: small head and eyes, day 5: small head and eyes, body a bit thin, underdeveloped liver/gut, sometimes body curved dorsally a little |  |  | | |
| hi3808 | small nuclear ribonucleoprotein F | day 1: cns necrosis, slightly flat head; day 2: very small head and eye with a lot of necrosis, pericardial edema denting yolk, grey yolk; dead by day 5 |  | | | |
| hi3812 | novel (AN11 homolog) | day 5: rounder head with scooped out jaw (some ventral cartilages reduced or absent), underdeveloped liver/gut |  |  | | |
| hi3817 | seryl-tRNA synthetase | day 3: slightly smaller head and eye; day 4: small head and eye, circulation cut off to trunk (and later to the head), such that blood circulates only in a small loop between the heart and jaw day 5: small head and eye, blood circulation remains restricted but slows down and eventually stops entirely, underdeveloped liver/gut |  |  | | |
| hi3820a | epithelial cell transforming sequence 2 oncogene | day 1: cns necrosis, thin midbrain/hindbrain boundary, slightly flat head; day 2 very bad necrosis in head, round grey yolk with thin extension, body curved up; most dead by day 5; otherwise very small and underdeveloped, necrotic throughout |  |  | | |
| hi3820b | 60S ribosomal protein L11 | day 1: a little cns necrosis; day 2: slightly smaller head and eyes, round grey yolk with thin extension; day 5: small head and eyes, underdeveloped liver/gut, sometimes a little pc edema |  | | | |
| hi3893 | 60S ribosomal protein L28 | day 1: may see pinched midbrain/hindbrain boundary, a bit of cns necrosis; day 2: cns necrosis, round grey yolk with thin extension; day 5: small head/eyes & underdeveloped guts |  |  |  | |
| hi3959a | novel (KIAA0643-like) | day 2: ventrally curved body, may see beginning of kidney cyst; day 5, curved or wavy body, kidney cyst |  |  |  | |
| hi3970 | SKP1A: S-phase kinase-associated protein 1A | day 3: small and slightly necrotic head and eyes; day 5: small head and eyes, round grey yolk, underdeveloped liver/gut, sometimes with a lot of pericardial edema, sometimes not |  | | | |
| hi4026 | FEN1b (flap structure specific endonuclease 1) | day 2: some cns and eye necrosis ; day 3: small head and eyes; day 5: small head and eyes, underdeveloped liver/gut |  |  | | |
| hi4049 | DEAD/H box 16 RNA helicase | day 1: pinched midbrain/hindbrain boundary, pointy forebrain, a bit of cns necrosis; day 2: cns necrosis, round grey yolk with thin extension, thin body; dead by day 5 |  | | | |
| hi4063b | DKFZp586G0123-like (possibly calcium binding transporter) | day 5: smaller, rounder and slightly necrotic head, smaller eyes, jaw small and jutting ventrally, sometimes a bit of pc edema (variable), underdeveloped liver/gut |  |  | | |
| hi4134 | methionine-tRNA synthetase | day 3 slightly small head and eyes; day 5: small head and eyes, underdeveloped liver/gut |  |  | | |
| hi4153 | signal recognition particle, 68kDa | day 5: a little cns necrosis, small head and eyes with edema around head; cartilage does not stain well with Alcian blue |  |  | | |
| hi4161a | GLE1-like RNA export mediator | day 2: cns necrosis; day 3: small head and eyes; day 5: very small head and eyes, underdeveloped liver/gut, pericardial edema (edema can extend over the head too) |  | | | |
| hi4166 | PKD2 | day 2: body curved dorsally. Ditto days 3-5 |  |  |  | |
| hi4201b | novel (cdc39-like) | day 3: small head and eye; day 5: small head and eye, underdeveloped liver/gut, a little pericardial edema and edema around eyes or head |  |  |  | |
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