| Family | Zebrafish Gene | Phenotypic Description | Image #1 | Image #2 | Image #3 | Image #4 |
| hi1134 | sox9a | day 5: a bit rounder head, especially jaw reduced: Alcian blue shows lack of head cartilage (more details in Yan et al., Development 129: 5065-5079 (2002)) |  |  |  | |
| hi1143 | chromosome adhesion protein SMC4-like 1 | day 2: cns necrosis; day 5: very small head and eyes, underdeveloped liver/gut, a little pericardial edema |  |  | | |
| hi1146 | DNA polymerase alpha | day 2: cns necrosis, small head and eyes, inflated hindbrain ventricle, thin and often curved body, rounder yolk with no extension; days 3-5, necrosis spreads throughout body, body wasting, small head and eyes and body, edema (pericardial and elsewhere), some dead by day 5 |  |  | | |
| hi1159 | splicesome-associated protein 49 | day 2: slight cns necrosis; day 5: very small head and eyes, short necrotic body, underdeveloped liver/gut, round unconsumed yolk, sometimes dead |  | | | |
| hi1182 | telomere binding protein 2 | day 2: cns necrosis; day 3, small head and eyes, day 5: small head, very small eyes, sometimes do inflate swim bladder |  |  | | |
| hi1207 | v-ATPase 16 kDa proteolipid subunit | day 2: no pigment and a little cns necrosis; d5: less pigment, also small head and eyes, underdeveloped liver/gut, sometimes bent and/or dying |  | | | |
| hi1227 | 40S ribosomal protein S12 | day 2: small head and eyes, slightly inflated hindbrain ventricle, round yolk with thin extension; day 5: a bit smaller head and eyes, underdeveloped liver/gut, sometimes a little pericardial edema |  |  | | |
| hi1241 | novel (FLJ13912-like) | day 2: a little cns necrosis; day 3: a little cns necrosis, small head and eyes, round yolk; d5: smaller eyes, flat/narrow head, underdeveloped liver and gut |  |  | | |
| hi1244 | MCM2 | day 2: maybe a little cns necrosis day 3: slightly smaller head and eye; day 5: small head and eyes, underdeveloped liver/gut, wavy body |  | | | |
| hi1257 | novel (AK027570-like) | day 5: thinner/pointy head, smaller eyes, a bit of pericardial edema |  |  | | |
| hi1262 | SIL (TAL1-interupting locus-like) | day 2: a little cns necrosis, head and eyes slightly smaller; day 5: small head and eyes, pericardial edema, underdeveloped liver/gut, sometimes bent up, down, or S-shaped |  | | | |
| hi1284 | 60S ribosomal protein L24 | day 2: slightly smaller head and eyes; day 5: small head and eyes, underdeveloped liver/gut, unconsumed yolk |  | | | |
| hi1290 | 40S ribosomal protein S3a | early day 1: a little cns necrosis, late day 1: hindbrain ventricle inflated; day 2: much smaller head/eye, pericardial edema, body thin/wasting; embryos get progressively more necrotic/shrivelled up and most are dead by day 5 |  |  | | |
| hi1320 | actopaxin | day 5: fin edges look ratty; sometimes inflate swim bladder |  | | | |
| hi1321 | foxI1 | day 1/2: small or only 1 otolith; day 5: body slightly thin, maybe bent; jaw "scooped out" (more details in Nissen et al., Development 130: 2543-2554 (2003)) |  | | | |
| hi1326 | survivin | day 2: cns necrosis, body maybe bent up; embryos get progressively more necrotic, most are dead by day 5 |  | | | |
| hi1370 | novel (FLJ12787-like) | day 1: pinched midbrain/hindbrain boundary, a bit of cns necrosis, head flatter; day 2: small head and eyes; day 5: small head and eyes, variably short and thin body, slight pericardial edema, underdeveloped liver/gut |  |  |  | |
| hi1371 | U1 small nuclear ribonucleoprotein C | day 2: cns necrosis, body sometimes bent up; day 5: very small and necrotic head and eyes, pericardial edema, underdeveloped liver/gut, thin bent/wasting body |  | | | |
| hi1373 | novel (MGC1346-like) | day 2: cns necrosis, body sometimes bent up; day 5: very small and necrotic head and eyes, pericardial edema, underdeveloped liver/gut, thin bent/wasting body |  | | | |
| hi1389 | N-cadherin | day 1: brain folds are funny/bumpy; day 2: smaller, bumpy head, body a bit thinner and sometimes bent; day 5: a bit smaller, bumpy head, body a bit thinner and sometimes bent |  |  |  | |
| hi1392 | MGC35261-like; twister | day 2: ventrally curved body, may see beginning of kidney cyst; day 5, ventrall curved trunk, kidney cyst |  |  |  | |
| hi1411 | MCM7 | day 2: cns necrosis, body maybe bent up; day 5: small and possibly necrotic head and eyes, pericardial edema (can also be over head), underdeveloped liver/guts, thin and bent/necrotic body; note: hi2704 is more severe than hi1411 |  |  | | |
| hi1422 | 60S ribosomal protein L9 | day 1/2 slightly pinched midbrain/hindbrain boundary, slightly smaller head; day 3: smaller head/eyes, yolk a bit rounder, day 5: slightly smaller head and eyes, underdeveloped liver/gut; sometimes inflate swim bladder |  |  | | |
| hi1433 | adenylosuccinate synthetase | day 2: cns necrosis, slightly smaller head and eyes; day 5: very small head and eyes, underdeveloped liver/gut, pericardial edema, sometimes necrtic body |  | | | |
| hi1437 | novel (FLJ10613-like) | day 1 slightly pinched midbrain/hindbrain boundary, a little cns necrosis, day 2: slightly smaller head, some cns necrosis, hindbrain ventricle slightly inflated; day 5: small head and eyes, underdeveloped liver/gut, unconsumed yolk, thin body |  |  |  | |
| hi1444 | 60S acidic ribosomal protein P1 | day 1/2 slightly pinched midbrain/hindbrain boundary, smaller head; day 3: small head and eyes, round grey yolk with thin extension, thin body; day 5: small head and eyes, underdeveloped liver/gut, sometimes inflate swim bladder (note: this phenotype seems very variable in severity) |  |  | | |
| hi1447 | DEAD/H box 97 RNA helicase | day 2: a little cns necrosis, slightly smaller head and eyes; day 5: small head and eyes, underdeveloped liver/gut |  | | | |
| hi1451 | novel (BING4-like) | day 1: slightly pinched midbrain/hindbrain boundary, a bit of cns necrosis; day 2: slightly smaller head, some cns necr, hindbrain vernticle mildly inflated; day 5: small and maybe necrotic head and eyes, underdeveloped liver/gut, pericardial edema, variably thin body, variably round grey yolk |  |  |  | |
| hi1463 | CD36-like 2 | day 1: hindbrain appears bumby, day 2: no/less body pigment, head maybe shorter/blockier; day 5: less body pigment, head is a bit small and misshapen, body often bent up a little, underdeveloped liver/gut |  | | | |
| hi1464 | DEAD/H box 19 RNA helicase | day 1: cns necrosis; day 2 very bad necrosis; embryos become increasingly necrotic and die day 3-5 |  | | | |
| hi1477 | novel (FLJ22626-like) | day 1: pinched midbrain/hindbrain boundary, a bit of cns necrosis, head flatter; day 2: necrosis is worse; day 5: sometimes dead, otherwise thin and necrotic body, small head and eye, pericardial edema, unconsumed yolk, underdeveloped liver/gut |  |  | | |
| hi1479 | 40S ribosomal protein SA | day 1: cns necrosis, thin midbrain/hindbrain boundary, slightly flat head; day 2 cns necrosis, small head and eyes, round grey yolk with thin extension; d3-5: increasingly smaller head and eyes, necrosis spreads a bit into body, pericardial edema, underdeveloped liver and gut, round grey yolk |  |  |  | |
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