HST 583 Calendar

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Date	Lecture Monday 3:00-4:30 PM and Wednesday 2:00-3:30 PM Room E25-119 (except as noted)	Lab Monday 1:00-2:30 PM Room 1-115 (except as noted)	Discussion Wednesday 3:30-4:30 PM Room E25-117
Overview
9/4 Wed	Introduction to course. Randy Gollub Introduction to Functional Magnetic Resonance Imaging. Bruce Rosen		Safety and human subjects issues, pt. 1. Video. Ethics module. Notes on human subjects Randy Gollub Followed by Reception for students, alum & faculty at 4:30-6:30 in E25-119
Functional Neural Systems
9/9 Mon	Overview of Neural Systems. Randy Gollub Neural Signal Processing. Emery Brown Hand out problem set #1	Introduction to Lab, viewing MR images, and MatLab. Rick Hoge
9/11 Wed	Visual System. Wim Vanduffel Somatosensory and Motor Systems. Chris Moore		How the brain processes visual information, insights & controversies from neuroimaging studies (Kanwisher & Haxby papers) Kanwisher/Vanduffel/Moore
9/16 Mon	Class taught in Conference Room A at Bldg. 149, Charlestown Navy Yard Memory Systems. Cary Savage Attention, motivation, emotion. George Bush	MGH Martinos Center, Bay 4, MRI Tour LAB 1) Introduction to fMRI data acquisition, Part 1- acquisition. Rick Hoge
Imaging Physiology
9/18 Wed	Overview of Imaging Physiology Applied respiratory and cardiovascular physiology I. Robert Banzett Problem Set #1 due		Coupling between neural activity and CBF changes (Iadecola & Mintun papers). Randy Gollub
9/23 Mon	Holiday - MIT observes.
9/25 Wed	Applied respiratory and cardiovascular physiology II. Robert Banzett Hand out problem set #2		Impact of physiological noise on analysis and interpretation of fMRI data. Robert Banzett
9/30 Mon	Cerebrovascular anatomy and neural regulation of CNS blood flow. Randy Gollub	LAB 1) Introduction to fMRI data acquisition, Part 2- analysis. Rick Hoge & Jorge Jovicich
10/2 Wed	Neurovascular coupling. Global vs regionally specific changes in CBF and metabolism. Robert Banzett/Randy Gollub		Localization in fMRI data sets- comparison with other types of neuroscience data (Veltman & Disbrow papers) Chris Moore/Banzett
Physics of Image Acquisition
10/7 Mon	Class taught in Conference Room A at Bldg. 149, Charlestown Navy Yard Overview of structural and functional MRI signal acquisition. Bruce Rosen Hand out problem set #3 Lab Report #1 due	MGH Martinos Center, Bay 4 LAB 2) Biophysical basis of fMRI signals,Part 1- acquisition. Robert Banzett & Rick Hoge
10/9 Wed	The NMR signal: Magnetization, Excitation, Detection, NMR signal, SNR. Larry Wald Monitoring the NMR signal: NMR measurements, T2, T2, Gradients, Gradient-Echo, Spin-echo. Larry Wald* Problem Set #2 due		MR signal Detection, phased array receiver coils. Larry Wald
10/14 Mon	Holiday- Columbus Day
10/16 Wed	MRI: Spatially encoding the NMR signal Frequency, Slice and Phase encoding, Spin Warp. Larry Wald Basics of Fast MRI K-space, Fast imaging, distortions. Larry Wald		Parallel Image Acquisition strategies. Dan Sodickson and Larry Wald
10/21 Mon	Review: spatial encoding, k-space. Jorge Jovicich MonRI contrasts: T1,T2,T2, diffusion. Jorge Jovicich*	LAB 2) Biophysical basis of fMRI signals,Part 2- analysis. Robert Banzett & Rick Hoge
10/23 Wed	BOLD contrast (part 1) hemodynamic response, temporal, spatial resolution. Larry Wald Improving fMRI signal detection using physiological data. Jennifer Melcher		Temporal and spatial resolution (e.g. New Logothetis articles in Neuron and Nature) OPEN
10/28 Mon	BOLD contrast (part 2) physiological noise, field strength. Larry Wald Alternatives to BOLD Review of BOLD, Perfusion vs BOLD, Arterial Spin Labelling, Cerebral Blood Volume. Jorge Jovicich Lab Report #2 due	LAB 3) Clustered Volume Acquisition (CVA) & cardiac gating techniques for detection of auditory activation and brainstem signals lab. Jennifer Melcher & Irina Sigalovsky
10/30 Wed	Physics of Diffusion weighted imaging, Dave Tuch Physics and clinical applications of Perfusion weighted imaging. Greg Sorensen Problem Set #3 due		ASL (Wong Paper) Larry Wald, Rick Hoge, Joe Mandeville
11/4 Mon	Quantitative fMRI. CBV, CBF & ASL. Rick Hoge Lab Report #3 due	LAB 4) Diffusion Gradients Lab. Dave Tuch and Rick Hoge
11/6 Wed	Mid-term Exam		Safety and human subjects issues, pt. 2. Ethics module. Randy Gollub
11/11 Mon	Holiday- Veteran's Day
Experiment Design
11/13 Wed	General Principles of Experimental Design, pt. 1. Robert Savoy Hand out problem set #4 Lab Report #4 due		Paradigm design (Manoach and Stark) Dara Manoach, Robert Savoy
11/18 Mon	General Principles of Experimental Design, pt. 2. Robert Savoy Psychological state variables in imaging. Robert Savoy	LAB 5) Statistical analysis of fMRI data. Gollub, Savoy, Hoge, Greve, Lai, Vangel
Statistical Analysis
11/20 Wed	Overview of fMRI statistical Analysis (Randy or Doug) Introduction to univariate analysis of fMRI data- part 1. Doug Greve Mark's probability notes Mark's statistics notes Problem Set #4 due		Review of principles of statistical inference. Mark Vangel, Doug Greve, Emery Brown
11/25 Mon	Introduction to univariate analysis of fMRI data- part 2. Doug Greve Hand out problem set #5	LAB 5) Statistical analysis of fMRI data. Gollub, Savoy, Hoge, Greve, Lai, Vangel
11/27 Wed	Multivariate Statistical Approaches to fMRI data analysis. Mark Vangel Group analysis of fMRI data Mark Vangel Lab Report #5 due		The turkey chased us away- no class now.
12/2 Mon	Building new Statistical Models for fMRI data. Emery Brown Emery's extra notes	LAB 6) Morphometric segmentation. Bruce Fischl and David Kennedy
12/4 Wed	Statistical efficiency in fMRI paradigm design. Doug Greve Problem Set #5 due		Statistics Q'&'A Mark Vangel and Randy Gollub
Structural Analysis
12/9 Mon	Surface based anatomical analysis. Bruce Fischl Lab Report #6 due	LAB 7) Course review (REQUIRED). Megan Hepler
12/11 Wed	Spatial normalization for anatomic analysis. Clinical and basic neuroscience applications of diffusion tensor imaging. Dave Kennedy		What is baseline (discussion of Squire paper) Jim Hopper
12/16 Mon	Final Exam (3:00 PM-5:00 PM) E25-119