HST 583 Fall 2002 Calendar
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Date
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Lecture Monday 3:00-4:30 PM and Wednesday 2:00-3:30 PM Room E25-119 (except as noted) |
Lab Monday 1:00-2:30 PM Room 1-115 (except as noted) |
Discussion Wednesday 3:30-4:30 PM Room E25-117 |
Overview | |||
9/4 Wed |
Introduction to course. Randy Gollub Introduction to Functional Magnetic Resonance Imaging. Bruce Rosen | Safety and human subjects issues, pt. 1. Video. Ethics module. Notes on human subjects Randy Gollub Followed by Reception for students, alum & faculty at 4:30-6:30 in E25-119 |
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Functional Neural Systems | |||
9/9 Mon |
Overview of Neural Systems. Randy Gollub Neural Signal Processing. Emery Brown Hand out problem set #1 |
Introduction to Lab, viewing MR images, and MatLab. Rick Hoge |
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9/11 Wed |
Visual System. Wim Vanduffel Somatosensory and Motor Systems. Chris Moore |
How the brain processes visual information, insights & controversies from neuroimaging studies (Kanwisher & Haxby papers) Kanwisher/Vanduffel/Moore |
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9/16 Mon |
Class taught in Conference Room A at
Bldg. 149, Charlestown Navy Yard Memory Systems. Cary Savage Attention, motivation, emotion. George Bush |
MGH Martinos Center, Bay 4, MRI Tour LAB 1) Introduction to fMRI data acquisition, Part 1- acquisition. Rick Hoge |
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Imaging Physiology | |||
9/18 Wed |
Overview of Imaging Physiology
Applied respiratory and cardiovascular physiology I. Robert Banzett Problem Set #1 due |
Coupling between neural activity and CBF changes (Iadecola & Mintun papers). Randy Gollub |
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9/23 Mon |
Holiday - MIT observes. | ||
9/25 Wed |
Applied respiratory and cardiovascular physiology II. Robert Banzett Hand out problem set #2 |
Impact of physiological noise on analysis and interpretation of fMRI data. Robert Banzett |
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9/30 Mon |
Cerebrovascular anatomy and neural regulation of CNS blood flow. Randy Gollub |
LAB 1) Introduction to fMRI data acquisition, Part 2- analysis. Rick Hoge & Jorge Jovicich |
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10/2 Wed |
Neurovascular coupling. Global vs regionally specific changes in CBF and metabolism. Robert Banzett/Randy Gollub |
Localization in fMRI data sets- comparison with other types of neuroscience data (Veltman & Disbrow papers) Chris Moore/Banzett |
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Physics of Image Acquisition | |||
10/7 Mon |
Class taught in Conference Room A at
Bldg. 149, Charlestown Navy Yard Overview of structural and functional MRI signal acquisition. Bruce Rosen Hand out problem set #3 Lab Report #1 due |
MGH Martinos Center, Bay 4 LAB 2) Biophysical basis of fMRI signals,Part 1- acquisition. Robert Banzett & Rick Hoge |
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10/9 Wed |
The NMR signal: Magnetization, Excitation, Detection, NMR signal, SNR.
Larry Wald Monitoring the NMR signal: NMR measurements, T2*, T2, Gradients, Gradient-Echo, Spin-echo. Larry Wald Problem Set #2 due |
MR signal Detection, phased array receiver coils. Larry Wald |
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10/14 Mon |
Holiday- Columbus Day | ||
10/16 Wed |
MRI: Spatially encoding the NMR signal Frequency, Slice and Phase encoding, Spin Warp. Larry Wald Basics of Fast MRI K-space, Fast imaging, distortions. Larry Wald |
Parallel Image Acquisition strategies. Dan Sodickson and Larry Wald | |
10/21 Mon |
Review: spatial encoding, k-space. Jorge Jovicich MonRI contrasts: T1,T2,T2*, diffusion. Jorge Jovicich |
LAB 2) Biophysical basis of fMRI signals,Part 2- analysis. Robert Banzett & Rick Hoge |
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10/23 Wed |
BOLD contrast (part 1) hemodynamic response, temporal, spatial resolution. Larry Wald Improving fMRI signal detection using physiological data. Jennifer Melcher |
Temporal and spatial resolution (e.g. New Logothetis articles in Neuron and Nature) OPEN |
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10/28 Mon |
BOLD contrast (part 2) physiological noise, field strength. Larry Wald Alternatives to BOLD Review of BOLD, Perfusion vs BOLD, Arterial Spin Labelling, Cerebral Blood Volume. Jorge Jovicich Lab Report #2 due |
LAB 3) Clustered Volume Acquisition (CVA) & cardiac gating techniques for detection of auditory activation and brainstem signals lab. Jennifer Melcher & Irina Sigalovsky |
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10/30 Wed |
Physics of Diffusion weighted imaging, Dave Tuch Physics and clinical applications of Perfusion weighted imaging. Greg Sorensen Problem Set #3 due |
ASL (Wong Paper) Larry Wald, Rick Hoge, Joe Mandeville |
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11/4 Mon |
Quantitative fMRI. CBV, CBF & ASL. Rick Hoge Lab Report #3 due |
LAB 4) Diffusion Gradients Lab. Dave Tuch and Rick Hoge | |
11/6 Wed |
Mid-term Exam | Safety and human subjects issues, pt. 2. Ethics module. Randy Gollub |
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11/11 Mon |
Holiday- Veteran's Day | ||
Experiment Design | |||
11/13 Wed |
General Principles of Experimental Design, pt. 1. Robert Savoy Hand out problem set #4 Lab Report #4 due |
Paradigm design (Manoach and Stark) Dara Manoach, Robert Savoy |
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11/18 Mon |
General Principles of Experimental Design, pt. 2. Robert Savoy Psychological state variables in imaging. Robert Savoy |
LAB 5) Statistical analysis of fMRI data. Gollub, Savoy, Hoge, Greve, Lai, Vangel |
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Statistical Analysis | |||
11/20 Wed |
Overview of fMRI statistical Analysis (Randy or Doug) Introduction to univariate analysis of fMRI data- part 1. Doug Greve Mark's probability notes Mark's statistics notes Problem Set #4 due |
Review of principles of statistical inference. Mark Vangel, Doug Greve, Emery Brown |
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11/25 Mon |
Introduction to univariate analysis of fMRI data- part 2. Doug Greve Hand out problem set #5 |
LAB 5) Statistical analysis of fMRI data. Gollub, Savoy, Hoge, Greve, Lai, Vangel |
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11/27 Wed |
Multivariate Statistical Approaches to fMRI data analysis. Mark Vangel Group analysis of fMRI data Mark Vangel Lab Report #5 due |
The turkey chased us away- no class now. | |
12/2 Mon |
Building new Statistical Models for fMRI data. Emery Brown Emery's extra notes | LAB 6) Morphometric segmentation. Bruce Fischl and David Kennedy |
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12/4 Wed |
Statistical efficiency in fMRI paradigm design. Doug Greve Problem Set #5 due |
Statistics Q'&'A Mark Vangel and Randy Gollub |
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Structural Analysis | |||
12/9 Mon |
Surface based anatomical analysis. Bruce Fischl Lab Report #6 due |
LAB 7) Course review (REQUIRED). Megan Hepler |
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12/11 Wed |
Spatial normalization for anatomic analysis. Clinical and basic neuroscience applications of diffusion tensor imaging. Dave Kennedy | What is baseline (discussion of Squire paper) Jim Hopper |
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12/16 Mon |
Final Exam (3:00 PM-5:00 PM) E25-119 |