Xinliang Xu

My work tries to build analytical models in order to achieve a better understanding about the property-structure relationship of DNA. More specificly, we would like to know if deformations of DNA from its ideal structures have an impact on DNA's ability to bind with external proteins, and how does such an impact behave as a function of the distance between the binding site and the deformation site. A good description of such property-structure relation will greatly enhance our ability in designing proteins (drugs) for more efficient detections of DNA defects so as to help cure the disease associated with such genetic defects.

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