Predicting the evolution of drug resistance

in HIV Protease
 

Mehran Kardar

Tom Butler, John Barton

Arup C. Chakraborty

Outline

I.       HIV: Lifecycle and drug targets                                         

II.     Protease: Inhibitors and Resistance                                

III.    Sequence: Diversity and Prevalence

IV.    Retrodicting PI resistance sites

V.    Summary:

Patient-derived HIV sequences reflect successful responses to diverse immune system challenges; maximum entropy analysis is a promising tool for extracting viral constraints.

Next (HIV) Outline HIV Protease Sequence Resistance sites Summary