UCSB                                GOOP meeting                            February 26, 2009

Thymic selection of T-cell receptors and Statistical Mechanics

Abhishek Jha, Eric Huseby, Eugene Shakhnovich

Mehran Kardar (MIT)

Andrej Kosmrlj, Arup K. Chakraborty

Summary

I.       Introduction: T-cells, receptors, thymic selection                                       

II.      Model: Binding energy, selection, extreme values, statistical physics                                    

III.     Results: Amino-acid composition of TCRs, specificity in transgenic mice         

IV.     Summary

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