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Transition in pulsed contractions during wild-type ventral furrow formationMovie of embryo undergoing gastrulation. Bolded white pulses are ratcheted pulses. Lighter white pulses are unconstricting or unratcheted pulses. Cells transition from unratcheted to ratcheted pulses. Video / Shicong 'Mimi' Xie

Twist is required for proper order of different contractile pulsesMovie of embryo depleted of Twist undergoing gastrulation. Bolded pulses are ratcheted pulses. Lighter white pulses are unconstricting or unratcheted pulses. Cells do not unidirectionally transition from having unratcheted pulses to ratcheted pulses. Video / Shicong 'Mimi' Xie

Open Positions

Interested in Joining the Lab?

The Martin lab is an interdisciplinary research group. We encourage students and postdocs with experimental or computational backgrounds to inquire about our lab. Contact Adam Martin with your CV and research interests if you are interested.

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Welcome to Martin Lab!

“It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life.”

Lewis Wolpert

To form a complex organ, simple tissues must be folded, stretched, compressed, and otherwise sculpted into a precise form in a process called tissue morphogenesis. One of the most dramatic examples of tissue morphogenesis occurs during embryonic development, when primitive planar tissues are folded to generate separate layers that will give rise to different parts of the body during gastrulation. Tissue morphogenesis requires that cytoskeletal machines generate forces that change cell shape and deform the tissue. The molecular mechanism by which the cytoskeleton generates force is not known for many of the diverse cell shape changes and tissue movements that underlie morphogenesis. Furthermore, how force generation by hundreds or thousands of cells is coordinated by biochemical and mechanical signals in a tissue is an important step to understand how cells collectively deform a tissue.

The Martin lab is interested in how tissues get their shape. Given that tissue morphogenesis fundamentally involves movement, we have developed a system to visualize and quantify the dynamics of molecules, cells, and tissues during gastrulation. We focus on mesoderm invagination in the fruit fly, Drosophila melanogaster, because cell shape changes and cytoskeletal dynamics can be readily imaged by confocal microscopy during a process that occurs on the time scale of minutes. Live imaging can be combined with genetic (mutants, RNAi), cell biological (drug injections), computational (image segmentation and analysis), biophysical (laser cutting), and biochemical (complex purification) approaches to functionally dissect cell shape change in the embryo.

Recent News

Jeanne awarded NIH Fellowship | Jun'15

Jeanne Jodoin received an F32 fellowship from the NIH Congratulations to Jeanne Jodoin, who was awarded a prestigious NIH F32 postdoctoral fellowship. Read more >>

Elena wins poster prize | Jun'15

Elena Kingston won a best poster prize at the 2015 Building 68 retreat Congratulations Elena Kingston on winning the best poster prize at the Building 68 retreat. We have won a poster prize each year for the past 3 years. Nice job Mimi, Claudia, and now Elena. Read more >>

Welcome Clint | Jun'15

MIT Biology graduate student, Clint Ko, is joining our lab Biology graduate student, Clint Ko, is joining our lab. Clint was an undergrad at Cornell University where he worked on plant development. We are happy he has turned to the fruit fly for his next system. Read more >>

Mimi’s paper in Nature Commun | May'15

Shicong 'Mimi' Xie's publication in Nature Communications Congratulations Mimi Xie on publication in Nature Communications! Mimi discovers interactions between cells that could lead to cooperative behavior during tissue folding. Read more >>