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3 rows show a tumor responding to types of treatment. Columns are labeled “DMSO, 5-FU, 5-FUR, 5-FdUR.” Top shows grey microscopic image of tumor. Middle row is stained blue and shows blue lumps. Bottom row is stained green and shows smaller bits.
In the two middle panels on the bottom row, the ribosomes (green) of patient-derived organoids are broken down by a version of 5-fluorouracil that targets RNA.

Spotlight: Oct 8, 2024

It’s long been thought that the cancer drug 5-fluorouracil works by damaging DNA, but researchers now show that in certain cancers, it interferes with RNA synthesis instead. The findings may influence how doctors treat many cancer patients.

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