Publications

2008

1. van Zundert B, Peuscher MH, Hynynen M, Chen A, Neve RL, Brown RH Jr, Constantine-Paton M, Bellingham MC. Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis. J Neurosci. 2008 Oct 22;28(43):10864-74.

2. Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5856-61.
   

3. Constantine-Paton M. Pioneers of cortical plasticity: six classic papers by Wiesel and Hubel. J Neurophysiol. 2008 Jun;99(6):2741-4.
   

4. Zhao JP, Constantine-Paton M. NR2A-/- mice lack long-term potentiation but retain NMDA receptor and L-type Ca2+ channel-dependent long-term depression in the juvenile superior colliculus. J Neurosci. 2007 Dec 12;27(50):13649-54.
   

5. Colonnese MT, Phillips MA, Constantine-Paton M, Kaila K, Jasanoff A. Development of hemodynamic responses and functional connectivity in rat somatosensory cortex. Nat Neurosci. 2008 Jan;11(1):72-9.
   

6. Yoshii A, Constantine-Paton M. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat Neurosci. 2007 Jun;10(6):702-11.
   

7. Zhao JP, Phillips MA, Constantine-Paton M. Long-term potentiation in the juvenile superior colliculus requires simultaneous activation of NMDA receptors and L-type Ca2+ channels and reflects addition of newly functional synapses. J Neurosci. 2006 Dec 6;26(49):12647-55.
   

8. Constantine-Paton M. Shining light on spike timing-dependent plasticity. Neuron. 2006 Apr 6;50(1):5-7.
   

9. Colonnese MT, Constantine-Paton M. Developmental period for N-methyl-D-aspartate (NMDA) receptor-dependent synapse elimination correlated with visuotopic map refinement. J Comp Neurol. 2006 Feb 10;494(5):738-51.
   

10. Miskevich F, Doench JG, Townsend MT, Sharp PA, Constantine-Paton M. RNA interference of Xenopus NMDAR NR1 in vitro and in vivo. J Neurosci Methods. 2006 Apr 15;152(1-2):65-73.
    

11. Colonnese MT, Zhao JP, Constantine-Paton M. NMDA receptor currents suppress synapse formation on sprouting axons in vivo. J Neurosci. 2005 Feb 2;25(5):1291-303.
    

12. Townsend M, Liu Y, Constantine-Paton M. Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses. J Neurosci. 2004 Dec 8;24(49):11098-107.
    

13. Zeringue HC, Constantine-Paton M. Post-transcriptional gene silencing in neurons. Curr Opin Neurobiol. 2004 Oct;14(5):654-9. Review.
    

14. Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol. 2004;5(9):R68.
    

15. Lu W, Constantine-Paton M. Eye opening rapidly induces synaptic potentiation and refinement. Neuron. 2004 Jul 22;43(2):237-49.
    

16. van Zundert B, Yoshii A, Constantine-Paton M. Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal. Trends Neurosci. 2004 Jul;27(7):428-37. Review.
    

17. Yoshii A, Sheng MH, Constantine-Paton M. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1334-9.
    

18. Townsend M, Yoshii A, Mishina M, Constantine-Paton M. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1340-5.
    

19. Colonnese MT, Shi J, Constantine-Paton M. Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currents. J Neurophysiol. 2003 Jan;89(1):57-68.
    

20. Miskevich F, Lu W, Lin SY, Constantine-Paton M. Interaction between metabotropic and NMDA subtypes of glutamate receptors in sprout suppression at young synapses. J Neurosci. 2002 Jan 1;22(1):226-38.
    

21. Shi J, Aamodt SM, Townsend M, Constantine-Paton M. Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors. J Neurosci. 2001 Aug 15;21(16):6233-44.
    

22. Colonnese MT, Constantine-Paton M. Chronic NMDA receptor blockade from birth increases the sprouting capacity of ipsilateral retinocollicular axons without disrupting their early segregation. J Neurosci. 2001 Mar 1;21(5):1557-68.
    

23. Shi J, Townsend M, Constantine-Paton M. Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents. Neuron. 2000 Oct;28(1):103-14.
    

24. Constantine-Paton M. The plastic brain. Neurobiol Dis. 2000 Oct;7(5):515-9.
    

25. Aamodt SM, Shi J, Colonnese MT, Veras W, Constantine-Paton M. Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus. J Neurophysiol. 2000 Mar;83(3):1580-91.
    

26. Scheetz AJ, Nairn AC, Constantine-Paton M. NMDA receptor-mediated control of protein synthesis at developing synapses. Nat Neurosci. 2000 Mar;3(3):211-6.
    

27. Aamodt SM, Constantine-Paton M. The role of neural activity in synaptic development and its implications for adult brain function. Adv Neurol. 1999;79:133-44. Review.
    

28. Rentería RC, Constantine-Paton M. Nitric oxide in the retinotectal system: a signal but not a retrograde messenger during map refinement and segregation. J Neurosci. 1999 Aug 15;19(16):7066-76.
    

29. Lin SY, Constantine-Paton M. Suppression of sprouting: An early function of NMDA receptors in the absence of AMPA/kainate receptor activity. J Neurosci. 1998 May 15;18(10):3725-37.
    

30. Constantine-Paton M, Cline HT. LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become. Curr Opin Neurobiol. 1998 Feb;8(1):139-48. Review.
    

31. Scheetz AJ, Nairn AC, Constantine-Paton M. N-methyl-D-aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: a role for N-methyl-D-aspartate receptors in controlling protein synthesis. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14770-5.
    

32. Shi J, Aamodt SM, Constantine-Paton M. Temporal correlations between functional and molecular changes in NMDA receptors and GABA neurotransmission in the superior colliculus. J Neurosci. 1997 Aug 15;17(16):6264-76.
    

33. Hickmott PW, Constantine-Paton M. Experimental down-regulation of the NMDA channel associated with synapse pruning. J Neurophysiol. 1997 Aug;78(2):1096-107.
    

34. Scheetz AJ, Prusky GT, Constantine-Paton M. Chronic NMDA receptor antagonism during retinotopic map formation depresses CaM kinase II differentiation in rat superior colliculus. Eur J Neurosci. 1996 Jul;8(7):1322-8.
    

35. Rentería RC, Constantine-Paton M. Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro. J Neurobiol. 1996 Apr;29(4):415-28.
    

36. Scheetz AJ, Constantine-Paton M. NMDA receptor activation-responsive phosphoproteins in the developing optic tectum. J Neurosci. 1996 Feb 15;16(4):1460-9.
    

37. Yen L, Sibley JT, Constantine-Paton M. Analysis of synaptic distribution within single retinal axonal arbors after chronic NMDA treatment. J Neurosci. 1995 Jun;15(6):4712-25.
    

38. Norden JJ, Constantine-Paton M. Dynamics of retinotectal synaptogenesis in normal and 3-eyed frogs: evidence for the postsynaptic regulation of synapse number. J Comp Neurol. 1994 Oct 15;348(3):461-79.
    

39. Scheetz AJ, Constantine-Paton M. Modulation of NMDA receptor function: implications for vertebrate neural development. FASEB J. 1994 Jul;8(10):745-52. Review.
    

40. Hofer M, Prusky GT, Constantine-Paton M. Regulation of NMDA receptor mRNA during visual map formation and after receptor blockade. J Neurochem. 1994 Jun;62(6):2300-7.
    

41. Cline HT, McDonald JW, Constantine-Paton M. Glutamate receptor binding in juvenile and adult Rana pipiens CNS. J Neurobiol. 1994 May;25(5):488-502.
    

42. Hofer M, Constantine-Paton M. Regulation of N-methyl-D-aspartate (NMDA) receptor function during the rearrangement of developing neuronal connections. Prog Brain Res. 1994;102:277-85. Review.
    

43. Constantine-Paton M. Effects of NMDA receptor antagonists on the developing brain. Psychopharmacol Bull. 1994;30(4):561-5. Review.
    

44. Yen LH, Sibley JT, Constantine-Paton M. Fine-structural alterations and clustering of developing synapses after chronic treatments with low levels of NMDA. J Neurosci. 1993 Nov;13(11):4949-60.
    

45. Hickmott PW, Constantine-Paton M. The contributions of NMDA, non-NMDA, and GABA receptors to postsynaptic responses in neurons of the optic tectum. J Neurosci. 1993 Oct;13(10):4339-53.
    

46. Debski EA, Constantine-Paton M. The development of non-retinal afferent projections to the frog optic tectum and the substance P immunoreactivity of tectal connections. Brain Res Dev Brain Res. 1993 Mar 19;72(1):21-39.
    

47. Simon DK, Prusky GT, O'Leary DD, Constantine-Paton M. N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10593-7.
    

48. Udin SB, Scherer WJ, Constantine-Paton M. Physiological effects of chronic and acute application of N-methyl-D-aspartate and 5-amino-phosphonovaleric acid to the optic tectum of Rana pipiens frogs. Neuroscience. 1992 Aug;49(3):739-47.
    

49. Debski EA, Cline HT, McDonald JW, Constantine-Paton M. Chronic application of NMDA decreases the NMDA sensitivity of the evoked tectal potential in the frog. J Neurosci. 1991 Sep;11(9):2947-57.
    

50. Debski EA, Constantine-Paton M. Evoked pre- and post-synaptic activity in the optic tectum of the cannulated tadpole. J Comp Physiol [A]. 1990 Aug;167(3):377-90.
    

51. Cline HT, Constantine-Paton M. The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. Neuron. 1990 Jun;4(6):899-908.
    

52. Mendez-Otero R, Constantine-Paton M. Granule cell induction of 9-O-acetyl gangliosides on cerebellar glia in microcultures. Dev Biol. 1990 Apr;138(2):400-9.
    

53. Cline HT, Constantine-Paton M. NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection. J Neurosci. 1990 Apr;10(4):1197-216.
    

54. Constantine-Paton M, Cline HT, Debski E. Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways. Annu Rev Neurosci. 1990;13:129-54.
    

55. Debski EA, Cline HT, Constantine-Paton M. Activity-dependent tuning and the NMDA receptor. J Neurobiol. 1990 Jan;21(1):18-32. Review.
    

56. Constantine-Paton M. NMDA receptor as a mediator of activity-dependent synaptogenesis in the developing brain. Cold Spring Harb Symp Quant Biol. 1990;55:431-43.
    

57. Cline HT, Debski EA, Constantine-Paton M. The role of the NMDA receptor in the development of the frog visual system. Adv Exp Med Biol. 1990;268:197-203. Review.
    

58. Steen P, Kalghatgi L, Constantine-Paton M. Monoclonal antibody markers for amphibian oligodendrocytes and neurons. J Comp Neurol. 1989 Nov 15;289(3):467-80.
    

59. Cline HT, Constantine-Paton M. NMDA receptor antagonists disrupt the retinotectal topographic map. Neuron. 1989 Oct;3(4):413-26.
    

60. Bonafede DM, Macala LJ, Constantine-Paton M, Yu RK. Isolation and characterization of ganglioside 9-O-acetyl-GD3 from bovine buttermilk. Lipids. 1989 Aug;24(8):680-4.
    

61. McDonald JW, Cline HT, Constantine-Paton M, Maragos WF, Johnston MV, Young AB. Quantitative autoradiographic localization of NMDA, quisqualate and PCP receptors in the frog tectum. Brain Res. 1989 Mar 13;482(1):155-8.
    

62. Katz LC, Constantine-Paton M. Relationships between segregated afferents and postsynaptic neurones in the optic tectum of three-eyed frogs. J Neurosci. 1988 Sep;8(9):3160-80.
    

63. Schlosshauer B, Blum AS, Mendez-Otero R, Barnstable CJ, Constantine-Paton M. Developmental regulation of ganglioside antigens recognized by the JONES antibody. J Neurosci. 1988 Feb;8(2):580-92.
    

64. Mendez-Otero R, Schlosshauer B, Barnstable CJ, Constantine-Paton M. A developmentally regulated antigen associated with neural cell and process migration. J Neurosci. 1988 Feb;8(2):564-79.
    

65. Cline HT, Debski EA, Constantine-Paton M. N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4342-5.
    

66. Constantine-Paton M, Ferrari-Eastman P. Pre- and postsynaptic correlates of interocular competition and segregation in the frog. J Comp Neurol. 1987 Jan 8;255(2):178-95.
    

67. Constantine-Paton M, Blum AS, Mendez-Otero R, Barnstable CJ. A cell surface molecule distributed in a dorsoventral gradient in the perinatal rat retina. Nature. 1986 Dec 4-10;324(6096):459-62.
    

68. Sanes DH, Constantine-Paton M. The development of stimulus following in the cochlear nerve and inferior colliculus of the mouse. Brain Res. 1985 Oct;354(2):255-67.
    

69. Sanes DH, Constantine-Paton M. The sharpening of frequency tuning curves requires patterned activity during development in the mouse, Mus musculus. J Neurosci. 1985 May;5(5):1152-66.
    

70. Reh TA, Constantine-Paton M. Eye-specific segregation requires neural activity in three-eyed Rana pipiens. J Neurosci. 1985 May;5(5):1132-43.
    

71. Reh TA, Constantine-Paton M. Growth cone-target interactions in the frog retinotectal pathway. J Neurosci Res. 1985;13(1-2):89-100.
    

72. Reh TA, Constantine-Paton M. Retinal ganglion cell terminals change their projection sites during larval development of Rana pipiens. J Neurosci. 1984 Feb;4(2):442-57.
    

73. Davis MR, Constantine-Paton M. Hyperplasia in the spinal sensory system of the frog. II. Central and peripheral connectivity patterns. J Comp Neurol. 1983 Dec 20;221(4):453-65.
    

74. Davis MR, Constantine-Paton M. Hyperplasia in the spinal sensory system of the frog. I. Plasticity in the most caudal dorsal root ganglion. J Comp Neurol. 1983 Dec 20;221(4):444-52.
    

75. Reh TA, Constantine-Paton M. Qualitative and quantitative measures of plasticity during the normal development of the Rana pipiens retinotectal projection. Brain Res. 1983 Nov;312(2):187-200.
    

76. Sanes DH, Constantine-Paton M. Altered activity patterns during development reduce neural tuning. Science. 1983 Sep 16;221(4616):1183-5.
    

77. Constantine-Paton M, Pitts EC, Reh TA. The relationship between retinal axon ingrowth, terminal morphology, and terminal patterning in the optic tectum of the frog. J Comp Neurol. 1983 Aug 10;218(3):297-313.
    

78. Reh TA, Pitts E, Constantine-Paton M. The organization of the fibers in the optic nerve of normal and tectum-less Rana pipiens. J Comp Neurol. 1983 Aug 10;218(3):282-96.
    

79. Constantine-Paton M. Trajectories of axons in ectopic VIIIth nerves. Dev Biol. 1983 May;97(1):239-44.
    

80. Davis MR, Constantine-Paton M, Schorr D. Dorsal root ganglion removal in Rana pipiens produces fewer motoneurons. Brain Res. 1983 Apr 18;265(2):283-8.
    

81. Constantine-Paton M, Law MI. The development of maps and stripes in the brain. Sci Am. 1982 Dec;247(6):62-70.
    

82. Law MI, Constantine-Paton M. A banded distribution of retinal afferents within layer 9A of the normal frog optic tectum. Brain Res. 1982 Sep 16;247(2):201-8.
    

83. Law MI, Constantine-Paton M. Anatomy and physiology of experimentally produced striped tecta. J Neurosci. 1981 Jul;1(7):741-59.
    

84. Constantine-Paton M, Ferrari-Eastman P. Topographic and morphometric effects of bilateral embryonic eye removal on the optic tectum and nucleus isthmus of the leopard frog. J Comp Neurol. 1981 Mar 10;196(4):645-61.
    

85. Law MI, Constantine-Paton M. Right and left eye bands in frogs with unilateral tectal ablations. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2314-8.
    

86. Constantine-Paton M, Law MI. Eye-specific termination bands in tecta of three-eyed frogs. Science. 1978 Nov 10;202(4368):639-41.
    

87. Constantine-Paton M, Capranica RR. Axonal guidance of developing optic nerves in the frog. II. electrophysiological studies of the projection from transplanted eye primordia. J Comp Neurol. 1976 Nov 1;170(1):33-51.
    

88. Constantine-Paton M, Capranica RR. Axonal guidance of developing optic nerves in the frog. I. Anatomy of the projection from transplanted eye primordia. J Comp Neurol. 1976 Nov 1;170(1):17-31.
    

89. Constantine-Paton M, Caprianica RR. Central projection of optic tract from translocated eyes in the leopard frog (Rana pipiens). Science. 1975 Aug 8;189(4201):480-2.