Maheshri Research Group

Dynamics and variability in gene regulation and function


Finney-Manchester, S. and Maheshri, N. "Harnessing homologous recombination for in vivo targeted mutagenesis with TaGTEAM" Nucleic Acids Res. Accepted. [Featured Article]

Zopf, C.J. and Maheshri, N. "Acquiring fluorescence time-lapse movies of budding yeast and analyzing single-cell dynamics using GRAFTS." JoVE. Accepted.

Lee, T-H. and Maheshri, N. "A regulatory role for repeated decoy transcription factor binding sites in target gene expression." Mol Sys Biol. 2012 Mar; 8(576). [Article] [ HFSP Hot off the press]

Jin H., Heller D.A., Kalbacova M., Kim J.H., Zhang J., Boghossian A.A., Maheshri N., Strano M.S. "Detection of single-molecule H2O2 signaling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes." Nat Nanotechnol. 2010 Mar [PUBMED]

To, T.-L., Maheshri N. "Noise can induce bimodality in positive transcriptional feedback loops without bistability." Science. 2010 Feb; 327(5969):1142-5. [PDF] [PUBMED] [This week in Science] [Science Perspectives][GenomeWeb Daily News] [HFSP Hot off the press] [Nature Reviews Genetics Research Highlight ]

Octavio, L., Gedeon, K., and Maheshri N. “Epigenetic and conventional regulation is distributed among activators of FLO11 allowing tuning of population level heterogeneity in its expression.” PLoS Genetics. 2009 Oct; 5(10):e1000673. [PUBMED] [Nature Journal Club]

Maheshri, N. “Gene expression: dialing up the frequency.” Current Biology. 2008 Dec; 18(24): R1136-9. [PUBMED]

Maheshri, N. and O'Shea E.K. "Living with noisy genes: how cells function reliably with inherent variability in gene expression." Annual Review of Biophysics and Biomolecular Structure. 2007 Jun; 36: 413-434. [PUBMED]

Koerber J.T., Maheshri, N., Kaspar, B.K., Schaffer, D.V. "Construction of diverse adeno-associated viral libraries for directed evolution of enhanced delivery vehicles." Nat Protoc. 2006; 1(2):701-6. [PUBMED]

Bar-Even A., Paulsson J., Maheshri N., O'Shea E.K., Pilpel Y. and Barkai N. “Noise in gene expression scales with natural protein abundance.” Nat Genetics. 2006 Jun; 38 (6): 636-43. [PUBMED]

Maheshri, N., Koerber, J. T., Kaspar B.K. and Schaffer D.V. “Directed evolution of adeno-associated virus yields enhanced gene delivery vectors.” Nat Biotechnol. 2006 Feb; 24 (2): 198-204. [PUBMED]

Lee, G.K., Maheshri, N., Kaspar B. K. and Schaffer D. V. “PEG conjugation modestly protects adeno-associated viral vectors against neutralization by antibodies.” Biotechnol Bioeng. 2005 Oct 5; 92 (1): 24-34. [PUBMED]

Maheshri, N. and Schaffer D.V. “Computational and experimental analysis of DNA shuffling.” Proc Natl Acad Sci USA. 2003 Mar 18; 100 (6): 3071-6. [PUBMED]