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George B. Benedek Group
Alfred H. Caspary Professor of Physics and Biological Physics in the Department of Physics
Professor of Physics and Health Sciences and Technology in the
Harvard-MIT Division of Health Sciences and Technology

Recent Publications

Y. Wang, A. Lomakin, S. Kanai, R. Alex, G.B. Benedek, "Transformation of oligomers of lipidated peptide Induced by Change in pH."Molecular Pharmaceutics 12(2), 411-419 (2015).[PDF]

T.T. O'Malley, N.A. Oktaviani, D. Zhang, A. Lomakin, B. O'Nuallain, S. Linse, G.B. Benedek, M.J. Rowan, F.A.A. Mulder, D.M. Walsh "Ab dimers differ from monomers in structural propensity, aggregation paths
and population of synaptotoxic assemblies."Biochem.J. 461, 413-426 (2014).[PDF]

Y. Wang, R.F. Latypov, A. Lomakin, J.A. Meyer, B.A. Kerwin, S. Vunnum, G.B. Benedek, "Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation."Molecular Pharmaceutics 11(5), 1391-1402 (2014).[PDF]

Y. Wang, A. Lomakin, R.F. Latypov, J.P. Laubach, T. Hideshima, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek, "Phase transitions in human IgG solutions."J. Chem. Phys. 139, 121904(1-9) (2013). [PDF]

R. Roychaudhuri, M. Yang, A. Deshpande, G.M. Cole, S. Frautschy, A. Lomakin, G.B. Benedek, D.B. Teplow, "C-Terminal turn stability determines assembly differences between Aβ40 and Aβ42." J. Mol. Biol. 425, 292–308 (2013).[PDF]

S.T. O’Dowd, M.T. Ardah, P. Johansson, A. Lomakin, G.B. Benedek, K.A. Roberts, G. Cummins, O.M. El Agnaf, J. Svensson, H. Zetterberg, T. Lynch, D.M. Walsha, "The ELISA-measured increase in cerebrospinal fluid Tau that discriminates Alzheimer’s Disease from other Neurodegenerative Disorders is not attributable to differential recognition of Tau assembly forms." J. Alzheimer’s Disease, 33, 923–928 (2013). [PDF]

Aleksey Lomakin, and David Teplow "Quasielastic Light Scattering Study of Amyloid β-Protein Fibrillogenesis.", Amyloid Proteins: Methods and Protocols. Methods in Molecular Biology, vol. 299, Edited by: E. M. Sigurdsson, Humana Press Inc., Totowa, NJ, (2012).[PDF]

Y. Wang, A. Lomakin, T. Hideshima, J.P. Laubach, O.O. Ogun, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek, "Pathological crystallization of human immunoglobulins."Proc. Natl. Acad.Sci. USA, 109, 13359–13361 (2012).[PDF]

Y. Wang, A. Lomakin, R.F. Latypov, G.B. Benedek, "Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin" Proc. Natl. Acad.Sci. USA, 108, 16606–16611 (2011).[PDF]

S. Sinha, D.H.J. Lopes, Z. Du, E.S. Pang, A. Shanmugam, A. Lomakin, P. Talbiersky, A. Tennstaedt, K. McDaniel, R. Bakshi, P. Kuo, M. Ehrmann, G.B. Benedek, J. A. Loo, F.G. Klärner, T. Schrader, C. Wang, G. Bitan, "Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins" J. Am. Chem.Soc., 133, 16958–16969 (2011).[PDF]

Y. Wang, A. Lomakin, J.J. McManus, O. Ogun, G.B. Benedek, "Phase behavior of mixtures of human lens proteins Gamma D and Beta B1" Proc. Natl. Acad.Sci. USA, 107, 13282–13287 (2010). [PDF]

H.Li, B.H. Monien, A.Lomakin, R. Zemel, E.A.Fradinger, M. Tan, S.M.Spring, B.Urbanc, C.-W. Xie, G.B.Benedek, G.Bitan, "Mechanistic investigation of the inhibition of A beta 42 assembly and neurotoxicity by C-terminal fragments" Biochemistry, 49, 6358–6364(2010). [PDF]

P.Maiti, A.Lomakin, G.B.Benedek, G.Bitan, "Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity." Journal of Neurochemistry, 113, 1252–1262 (2010). [PDF]

B.Khaykovich, N.Kozlova, W.Choi, A. Lomakin, C.Hossain, Y.Sung, R.Dasari, M.S.Feld, G.B.Benedek, "Thickness-radius relationship and spring constants of cholesterol helical ribbons" Proc. Natl. Acad. Sci. USA, 106, 15663–15666 (2009). [PDF]