George B. Benedek Group, Publications

Recent Publications

R. Roychaudhuri, M. Yang, A. Deshpande, G.M. Cole, S. Frautschy, A. Lomakin, G.B. Benedek, D.B. Teplow, "C-Terminal turn stability determines assembly differences between Aβ40 and Aβ42." J. Mol. Biol. 425, 292–308 (2013).[PDF]

S.T. O’Dowd, M.T. Ardah, P. Johansson, A. Lomakin, G.B. Benedek, K.A. Roberts, G. Cummins, O.M. El Agnaf, J. Svensson, H. Zetterberg, T. Lynch, D.M. Walsha, "The ELISA-measured increase in cerebrospinal fluid Tau that discriminates Alzheimer’s Disease from other Neurodegenerative Disorders is not attributable to differential recognition of Tau assembly forms." J. Alzheimer’s Disease, 33, 923–928 (2013). [PDF]

Y. Wang, A. Lomakin, T. Hideshima, J.P. Laubach, O.O. Ogun, P.G. Richardson, N.C. Munshi, K.C. Anderson, G.B. Benedek, "Pathological crystallization of human immunoglobulins."Proc. Natl. Acad.Sci. USA, 109, 13359–13361 (2012).[PDF]

Y. Wang, A. Lomakin, R.F. Latypov, G.B. Benedek, "Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin" Proc. Natl. Acad.Sci. USA, 108, 16606–16611 (2011).[PDF]

S. Sinha, D.H.J. Lopes, Z. Du, E.S. Pang, A. Shanmugam, A. Lomakin, P. Talbiersky, A. Tennstaedt, K. McDaniel, R. Bakshi, P. Kuo, M. Ehrmann, G.B. Benedek, J. A. Loo, F.G. Klärner, T. Schrader, C. Wang, G. Bitan, "Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins" J. Am. Chem.Soc., 133, 16958–16969 (2011).[PDF]

Y. Wang, A. Lomakin, J.J. McManus, O. Ogun, G.B. Benedek, "Phase behavior of mixtures of human lens proteins Gamma D and Beta B1" Proc. Natl. Acad.Sci. USA, 107, 13282–13287 (2010). [PDF]

H.Li, B.H. Monien, A.Lomakin, R. Zemel, E.A.Fradinger, M. Tan, S.M.Spring, B.Urbanc, C.-W. Xie, G.B.Benedek, G.Bitan, "Mechanistic investigation of the inhibition of A beta 42 assembly and neurotoxicity by C-terminal fragments" Biochemistry, 49, 6358–6364(2010). [PDF]

P.Maiti, A.Lomakin, G.B.Benedek, G.Bitan, "Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity." Journal of Neurochemistry, 113, 1252–1262 (2010). [PDF]

B.Khaykovich, N.Kozlova, W.Choi, A. Lomakin, C.Hossain, Y.Sung, R.Dasari, M.S.Feld, G.B.Benedek, "Thickness-radius relationship and spring constants of cholesterol helical ribbons" Proc. Natl. Acad. Sci. USA, 106, 15663–15666 (2009). [PDF]

Erica A. Ferdinger, Bernhard H. Monien, Brigita Urbanc, Aleksey Lomakin, Miao Tan, Huiyuan Li, Sean M. Spring, Margaret M. Condron, Luis Cruz, Cui-Wei Xie, George B. Benedek, and Gal Bitan, "C-terminal peptides coassemble into Aß42 oligomers and protect neurons against Aß42-induced neurotoxicity" Proc. Natl. Acad. Sci. USA, 105, 14175–14180 (2008). [PDF]

McManus, J. J., Lomakin, A., Ogun, O., Pande, A., Basan M., Pande, J., and Benedek, G. B., "Altered phase diagram due to a single point mutation in human gD crystallin" Proc. Natl. Acad.Sci. USA, 104, 16856-16861 (2007).[PDF]

Also see: George M. Thurston, "Protein anisotropy turns solubility on its head",

Proc. Natl. Acad. Sci. USA, (2007), 104 (48), 18877 [PDF]

Grant, M. A., Lazo, N. D. , Lomakin A., Condron, M. M., Arai H., Yamin G., Rigby A. C., and Teplow D.B. Familial Alzheimer's disease mutations alter the stability of the amyloid -protein monomer folding nucleus, Proc. Natl. Acad. Sci. USA, 104, 16522-16527 (2007) [PDF]

Khaykovich, B., Hossain, C., McManus, J. J., Lomakin, A., Moncton, D. E., and Benedek, G. B., "Structure of cholesterol helical ribbons and self-assembling biological springs" Proc. Natl. Acad. Sci. USA, 104, 9656-9660 (2007) [PDF].

Also see: "Biological Springs from Cholesterol Ribbons?", The 2007 Annual Report

of the Advanced Photon Source at Argonne National Laboratory, May 2008, p.105