Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

 
  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

BioSyM and A*STAR researchers have developed new insights into how macrophages of polarized subtypes and carcinoma cells interact in the tumor microenvironment, paving way for understanding possible mechanisms for carcinoma-macrophage signalling in Epithelial-mesenchymal transition (EMT). This work is now published in the Journal "Macrophages"

Schematic representations of carcinoma aggregate dispersion at 0h and 36h in contact and separate condition into the microfluidic device. First column shows the macrophage subtype and the microfluidic device (media channel in pink, media channel with HUVECs in green, 3D collagen matrix for carcinoma aggregate and macrophage interactions). Second and third columns show the schemes for the contact or the separated condition at 0h and 36h (A549 aggregates in red; M0, M1, M2b and M2c in green; M2a in blue)

BioSyM and MBI researchers have evaluated the Single Cell Analysis (SCA) technique to address heterogenity issues associated with cancer cells. The complete review is now published in "International Journal of Cancer"

The illustration covers the process of tumor biopsy from a patient, to downstream characterization using pooled cell analysis or single cell techniques. The bar charts demonstrates the frequency of gene/protein expression detected; pooled sample analysis incorporates several tumor cell subpopulations, which may mask signals or lead to inaccurate display of relative expression levels, while single cell analysis allows breakdown to reveal individual heterogeneity for a more accurate assessment.

 

 

 

 

 

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Events

BioSyM Focused Seminar Series

From Biomolecules to Biofilms

11 April — 6 June 2016

23 May 2016, Monday, 4 pm

Dr. Binu Kundukad (SMART)

Biofilm architecture and composition -
determined from the mechanical properties of matrix

Location: CREATE Enterprise Level 5, Perseverance Rooms, UTown

 

Recent Publications

  1. Engineering a 3D microfluidic culture platform for tumor-treating field application", Scientific Reports
  2. "Mechanical signatures of microbial biofilms in micropillar-embedded growth chambers", Soft Matter
  3. "The polymer physics of single DNA confined in nanochannels" Advances in Colloid and Interface Science
  4. "M2a macrophages induce contact-dependent dispersion of carcinoma cell aggregates", Macrophage
  5. "Talbot multi-focal holographic fluorescence endoscopy for optically sectioned imaging", Optics letters
  6. "On-Chip Assessment of Human Primary Cardiac Fibroblasts Proliferative Responses to Uniaxial Cyclic Mechanical Strain", Biotechnology and BioEnginering
  7. "Intraoperative cell salvage in metastatic spine tumour surgery reduces potential for reinfusion of viable cancer cells", Eur. Spine J.
  8. "Single-cell profiling approaches to probing tumor heterogeneity", International Journal of Cancer
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    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications