Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

 
  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

Guided by quantum chemical calculations, BioSyM researchers, Liu Xiaogang (SMART Scholar) and Matthew Lang (PI), in collaboration with scientists from Chinese Academy of Sciences, have demonstrated a simple chemical substittution that greatly enhances fluorophore performance. They also revealed two major mechanisms that compromise the brightness and photostability of fluorophores. Such knowledge is a critical step towards developing high-performance fluorophores for advanced fluorescence imaging. Their results have been published in Journal of the American Chemical Society, one of the most prestigious chemistry journals.

X. Liu*, Q. Qiao, W. Tian, W. Liu, J. Chen, M. J. Lang, Z. Xu*, “Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability through effectively inhibiting twisted intramolecular charge transfer”, Journal of American Chemical Society, 2016, DOI: 10.1021/jacs.6b03924.

BioSyM researchers and collaborators have demonstrated a novel microfluidic device with embedded
electrodes that enables the application of an alternating electric field therapy to cancer cells in a 3D
extracellular matrix. The metastatic potential of the cancer cells and the proleferation rate were reduced after electric field treatment. These results form the basis for the potential use of both Chemotherapy and ElectricFieldTherapy in frontline cancer treatment regimens. {"Engineering a 3D microfluidic culture platform for tumor-treating field application", Scientific Reports}

Microfluidic device for Electric Field application. (A) Photo of three devices filled with food color dyes. Device cross section (B) and 3D CAD overview (C) with the conductive mixture (Ag/PDMS) in dark grey, cellculture media in pink, and 3D hydrogel region in green.
Equivalent electric circuit model of the microfluidic device

 

 

 

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Events

BioSyM Focused Seminar Series

Statistics and Optimisations in Biological Studies

13 June — 11 July 2016

27 June 2016, Monday, 4 pm

Asst. Prof. Timothy Saunders (MBI/NUS)

the Perils of the P-Value

Location: CREATE Theatrette, CREATE Tower Level 2 @ UTown

Recent Publications

  1. “Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability through effectively inhibiting twisted intramolecular charge transfer”, Journal of American Chemical Society
  2. "Microfluidic models for adoptive cell-mediated cancer immunotherapies", Drug Discovery Today
  3. "Mechanical properties of the superficial biofilm layer determine the architecture of biofilm", Soft Matter
  4. Engineering a 3D microfluidic culture platform for tumor-treating field application", Scientific Reports
  5. "Mechanical signatures of microbial biofilms in micropillar-embedded growth chambers", Soft Matter
  6. "The polymer physics of single DNA confined in nanochannels" Advances in Colloid and Interface Science
  7. "M2a macrophages induce contact-dependent dispersion of carcinoma cell aggregates", Macrophage
  8. "Talbot multi-focal holographic fluorescence endoscopy for optically sectioned imaging", Optics letters
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    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications