Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

Controlled electrical, mechanical and biochemical stimulation of Cells on a chip

BioSyM researchers describe in a new publication in Scientific Reports (Nature Publishing) 5, 11800 (2015), the design and fabrication of a microfluidic device capable of simultaneously providing mechanical, electrical, and biochemical stimulation, and subsequently extracting detailed morphological and gene-expression analysis on the cellular response.

Enhancing malaria diagnosis through microfluidic cell enrichment

BiosyM researchers have demonstrated an approach to increase the sensitivity and reliability of malaria diagnosis by Magnetic Resonance Relaxometry (MRR) using a microfluidic cell enrichment technique. The details are published in Scientific Reports, 5: 11425 (2015)



A collaborative study led by scientists from the Mechanobiology Institute (MBI), Singapore MIT Alliance for Research and Technology (SMART) - BioSystems and Micromechanics (BioSyM) and the National University Hospital at the National University of Singapore has led to the development of a novel technique for culturing circulating tumor cells (CTCs). This assay could be used for predicting cancer treatment outcome. Their work is published in Oncotarget on 6 May 2015.

......More BioSyM Highlights









SMART BioSyM, MBI and DBS-NUS brings to you A 2 week Bootcamp

CREATE Theatrette, Level 2, CREATE TOWER, U-Town
Registration and Info:

SMART Biosym Seminar by

Prof. Yan Jie (NUS - Physics & Mechanobiology Institute)

Mechanical Activation of Talin, α-Catenin, and Vinculin

Time: Monday, July 13, 2015, 4 pm
Location: CREATE Enterprise Level 5, Perseverance Rooms

Recent Publications

  1. "Controlled electromechanical cell stimulation on-a-chip" Scientific Reports (Nature Publishing)
  2. "Enhancing malaria diagnosis through microfluidic cell enrichment and magnetic resonance relaxometry detection", Scientific Reports (Nature Publishing)
  3. "Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy", Oncotarget
  4. "Metastable Knots in Confined Semiflexible Chains", Macromolecules
  5. "Malaria Detection using Inertial Microfluidics", Lab on A Chip
  6. "High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation", Integrative Biology
  7. "Improving liver fibrosis diagnosis based on forward and backward second harmonic generation signals", Applied Physics Letters
  8. “Origin of Metastable Knots in Single Flexible Chains”, Physical Review Letters

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications