Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

 
  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

A 3D microfluidic model for preclinical evaluation of TCR-engineered T Cells against solid tumors: BioSyM researchers and collaborators from Duke-NUS, A-STAR (IMCB, SICS) demonstrate an easily reproducible
and simple system to test whether TCR-engineered T cells can overcome the physical and metabolic
barriers present in the tumor microenvironment. The system is composed of a microdevice-based cellular
assay in which cancer cells and T cells interact in a 3D space. Conditions can be precisely regulated and the
ability of distinct preparations of engineered T cells to reach and kill cancer cells can be tracked over time.
We demonstrate that this 3D microdevice assay can measure the antitumor efficacy of TCR-engineered T
cells and that it can be easily customized to study the effect of specific biological conditions and clinical
scenarios on their function.

Andrea Pavesi (SMART/A*STAR-IMCB), Anthony T Tan (Duke-NUS), S.Koh (A*STAR-SICS), M.Colombo, E.Antonecchia, Carlo M, Giulia Adriani (SMART), M.T.Raimondi, R.D.Kamm (SMART/MIT), Antonio Bertoletti (Duke-NUS)/A*STAR-SICS), A 3D microfluidic model for preclinical evaluation of TCR-engineered T Cells against solid tumors, JCI Insight, June (2017)

BioSyM researchers at SMART, NUS & MIT have developed a novel interferometer for wide-field imaging using Fourier transform (FT) spectroscopy, which enables many biomedical applications requiring hyperspectral analysis through demonstration on fluorescent beads, cell and tissue specimen.A compressive data acquisition scheme is demonstrated for multiplexed imaging with many fluorescent species. In addition, a wide-field spectral Raman imaging is demonstrated with the new FT interferometer.  (Dushan et al "Near-common-path interferometer for imaging Fourier-transform spectroscopy in wide-field microscopy, Optica4 (5), May 2017)

 

 

 

 

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Events

BioSyM Annual Workshop and SAB Review: 11 & 12, January 2018 (Stay tuned for more information)

 

BioSyM Seminar

25 Sept 2017, Monday, 12 noon -1 pm

Mechanistic action of weak acid drugs on biofilms

Dr.Binu Kundukad (SMART)

Venue: Perseverance Rooms, Enterprise Wing L5, CREATE, NUS UTown


Recent Publications

  1. Probing eukaryotic cell mechanics via mesoscopic simulations PLOS Computational Biology
  2. A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma." Current medicinal chemistry
  3. Nanoconfinement greatly speeds up the nucleation and the annealing in single-DNA collapse, Soft matter
  4. Ground-State Conformers Enable Bright Single-Fluorophore Ratiometric Thermometers with Positive Temperature CoefficientsMaterials Chemistry Frontiers
  5. Mechanistic action of weak acid  drugs on biofilms” Scientific Reports
  6. Superfast maximum-likelihood reconstruction for quantum tomography", Phys. Rev. A
  7. Development of a classification model for non-alcoholic steatohepatitis (NASH) using confocal Raman micro-spectroscopy, Journal of Biophotonics
  8. A 3D microfluidic model for preclinical evaluation of TCR-engineered T Cells against solid tumors, JCI Insight

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications