Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

BioSyM Alumni Dr.Majid Ebrahimi Warkiani has been chosen as one of the 10 Honourees of MIT TR35 Innovators Under 35 Asia. Majid was one of the major contributors to BioSyM's research on Microfluidic Cell sorting and its application to sorting Circulating Tumor Cells (CTCs).

SMART-BioSyM start-up, AIM Biotech's microfluidics device (shown here) has an array of culturing sections, each with three chambers: a middle chamber for hydrogel and any cell type, and two side channels for culturing additional cell types.

Spinout’s microfluidics device better models how cancer and other cells interact in the body:

BioSyM - A*STAR - NUS researchers develop microfluidic "in vitro" platform to study Tumor Associated Macrophages (TAMs)

Researchers from SMART-BioSyM and A*STAR Institutes SIgN and IMCB have developed a novel microfluidic based in vitro tumor microenvironment. This platform was utilized to study the role of individual subtypes of macrophages (M0, M1, M2a, M2b and M2c) in human lung adenocarcinoma (A549) aggregate dispersion, as a representation of epithelial- mesenchymal transition (EMT). The findings may help in the development of immunotherapies based on enhancing the tumor-suppressive properties of TAMs. The results are now published in Oncotarget.

Membrane-less microfiltration using inertial microfluidics

BioSyM researchers have developed a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achieve a macroscopic volume processing rates (~ 500 mL/min). This platform has the desirable combinations of high throughput, low-cost, and scalability, making it compatible for a myriad of microfiltration applications and industrial purposes. The details are described in Scientific Reports (Nature Publishing) 5, 11018 (2015)


......More BioSyM Highlights









BioSyM Seminar

Distinguished Visitor Seminar

Optical imaging of reproductive and developmental
events in mouse models

Dr. Irina V. Larina
Assistant Professor
Department of Molecular Physiology and Biophysics, Baylor College of Medicine,

Houston, Texas, USA

Optical Coherence Elastography
Dr. Kirill V. Larin

Department of Biomedical Engineering,
University of Houston, Houston, TX, USA

Time: Friday, November 27, 2015, 11 am
Location: CREATE Enterprise Level 5, Perseverance Rooms


BioSyM Seminar

Thematic Seminar Series


Fluorescence (Cross-)Correlation Spectroscopy – What do we learn from fluorescence intensity fluctuations in bio-molecular systems, living cells and embryos?

Every Monday from 16th Nov - 7th Dec 2015

Seminar 3:
Single Plane Illumination fluorescence (cross)-correlation spectroscopy:
Mapping Diffusion Properties in Live cells and Organisms

Dr.Anand Singh
Research Fellow
Mechanobiology Institute
National University of Singapore

Time: Monday, November 30, 2015, 4 pm
Location: CREATE Enterprise Level 5, Perseverance Rooms


Recent Publications

  1. "Revisit the anomalous bending elasticity of sharply bent DNA", Biophysical Journal
  2. "Single-Particle Spectroscopic Study on Fluorescence Enhancement by Plasmon Coupled Gold Nanorod Dimers Assembled on DNA Origami", J. Phys. Chem. Lett.
  3. "Chaos analysis of viscoelastic chaotic flows of polymeric fluids in a micro-channel", AIP ADVANCES
  4. "Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and ?2 integrin interactions", Oncotarget
  5. “Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface”, Journal of Biophotonics.
  6. “Second harmonic generation microcopy is a novel technique for differential diagnosis of breast fibroepithelial lesions”, Journal of Clinical Pathology.
  8. "Membrane-less microfiltration using inertial microfluidics", Scientific Reports (Nature Publishing)
  9. "Controlled electromechanical cell stimulation on-a-chip" Scientific Reports (Nature Publishing)

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications