Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

In-Vivo hematopoietic recovery

Mesenchymal stem cells (red, with blue nuclei) on a surface with mechanical properties similar to those of bone marrow.


MIT and BioSyM researchers have shown MSCs that were culture expanded on substrata of varying mechanical stiffness were efficient and sustained hematopoietic recovery in vivo.Additionally, results demonstrated that mechanically modulated MSCs can robustly improve the cell secretory profile and improve radiation rescue, as compared to either sorted DhiMSCs subpopulations or unsorted MSCs grown on typical cell culture plastics from the same donor.

"Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome", Stem Cell Research & Therapy, 9:268 (2018).


Mucoadhesive PLGA Microparticles for Ocular Drug Delivery

BioSyM's findings pave the way for the rational design of mucoadhesive microparticulate ocular drug delivery systems that are capable of enhancing the bioavailability of topically applied drugs to eyes, as well as to other tissues whose epithelial surfaces contain mucosae.

Dawei Ding (SMART), Binu Kundukad (SMART), Ambika Somasundar (NUS), Sindhu Vijayan (SUTD), Saif A.Khan (NUS), Patrick Doyle (MIT/SMART), "Design of Mucoadhesive PLGA Microparticles for Ocular Drug Delivery"ACS Applied Bio Materials, Publication Date (Web): August 16, 2018







......More BioSyM Highlights









BioSyM Seminar

9 Nov 2018, Friday, 11 am

3D Sensing - Eyes of Artificial Intelligence

Dr.Chen Zhi (Vice President, Orbbec Co Ltd)

Venue: NUS UTown, Enterprise Level 5, Perseverance Room


Recent Publications

  1. "Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome", Stem Cell Research & Therapy
  2. "Quantitative phase microscopy of red blood cells during planner trapping and propulsion"Lab on a Chip
  3. "Design of Mucoadhesive PLGA Microparticles for Ocular Drug Delivery", ACS Applied Bio Materials
  4. Continuous Removal of Small Nonviable Suspended Mammalian Cells and Debris from Bioreactors Using Inertial Microfluidics”, Lab On A Chip
  5. "Universal Knowt Spectra for Confined Polymers", Macromolecules
  6. ”Influence of Protein Corona and Caveolae-Mediated Endocytosis on Nanoparticle Uptake and Transcytosis”, Nanoscale
  7. "Evidence from ITIR-FCS Diffusion Studies that the Amyloid-Beta (Aβ) Peptide Does Not Perturb Plasma Membrane Fluidity in Neuronal Cells", Journal of Molecular Biology
  8. "Extracellular vesicle-carried Jagged-1 inhibits HUVEC sprouting in a 3D microenvironment”Angiogenesis
  9. “Multicell migration tracking within angiogenic networks by deep learning-based segmentation and augmented Bayesian filtering”, Journal of Medical Imaging

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications