Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.


BioSyM Highlights

Malaria detection using inertial microfluidics

BioSyM researchers have developed a label-free, shear-modulated inertial microfluidic system to enrich malaria parasites from blood so as to facilitate a more reliable and specific PCR-based malaria detection. The technique is 100X more sensitive than the gold standard conventional microscopy analysis of thick blood smears. The details are published in the journal Lab On A Chip.

Origin of Metastable Knots in Single Flexible Polymer Chains

Long polymer molecules such as DNA can find themselves in knotted conformations. BioSyM researchers develop a new theory for the size distribution of knots on a flexible polymer such as DNA. Knotted DNA molecules present interesting phenomena in the process of sequencing genomes during nanopore translocation. The work is published now in Physical Review Letters, 114, 037801 (2015)

Cell therapy in pre-clinical models of bone marrow injury

BioSyM researchers demonstrate the Mesenchymal Stem Cell (MSC) subpopulation’s increased efficacy as a systematically administered cell therapy in preclinical models of bone marrow injury. Compared to survivability of 0% using current “state of the art” but functionally heterogeneous MSCs, this MSC subpopulation achieved >85% survivability. This study highlights the opportunity for rapid clinical translation of BioSyM's cell sorting approach and of this MSC subpopulation for several emerging applications of MSC regenerative medicine. The details of this work is now published in Stem Cells Translational Medicine.


......More BioSyM Highlights









SMART Biosym Seminar by

Professor Timothy Lu


Translating Synthetic Biology to Human Health Applications

Time: Thursday, March 26, 2015, 4 pm
Location: SMART Enterprise Level 5, Perseverance Rooms

Recent Publications

  1. "Malaria Detection using Inertial Microfluidics", Lab on A Chip
  2. "Improving liver fibrosis diagnosis based on forward and backward second harmonic generation signals", Applied Physics Letters
  3. “Origin of Metastable Knots in Single Flexible Chains”, Physical Review Letters
  4. “Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors From Mesenchymal Stromal Cells”, Stem Cells Translational Medicine
  5. "Jetting microfluidics with size-sorting capability for single-cell protease detection", Biosensors and Bioelectronics
  6. "Phase imaging using shifted wavefront sensor images", Optics Letters
  7. "Phase imaging for absorptive phase objects using hybrid uniform and structured illumination Transport of Intensity Equation", Optics Express
  8. "In vivo label-free quantification of liver microcirculation using dual-modality microscopy", Journal of Biomedical Optics

    ..........Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications