Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

BioSyM researcher awarded Open Fund - Young Individual Research Grant (YIRG)

BioSyM Post-Doctoral researcher Dr.Khoo Bee Luan has been awarded the NMRC’s  Open Fund - Young Individual Research Grant for advancing her research work on “Microfluidic Assay for Routine Evaluation of Anti-Cancer Drug Therapy on Clinical Human Circulating Tumor Cells”.

The outcome of this work will be impactful not only in terms of elucidating the mechanism of cancer metastasis, but also finding many new clinical counter-measures to combat the significant challenge of metastatic cancer in clinics


BioSyM & MBI researchers have demonstrated an efficient approach to evaluate response to cancer drug using patient-derived circulating tumor cell (CTC) cultures obtained from liquid biopsy. This new and robust liquid biopsy technique can potentially evaluate patient prognosis with CTC clusters during treatment and provide a noninvasive and inexpensive assessment that can guide drug discovery development or therapeutic choices for personalized treatment.

"Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment", Science Advances, 2 : e1600274 (2016)








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BioSyM Focused Seminar Series

Microdevices in Biological Studies

25 July — 10 October 2016

26th September 2016, Monday, 12-1 pm

Dr.Giulia Adriani (SMART)


Venue: NUS UTown, Enterprise Level 5, Perseverance Room

Recent Publications

  1. “Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma”, Oncoimmunology
  2. "Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment", Science Advances
  3. “Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability through effectively inhibiting twisted intramolecular charge transfer”, Journal of American Chemical Society
  4. "Microfluidic models for adoptive cell-mediated cancer immunotherapies", Drug Discovery Today
  5. "Mechanical properties of the superficial biofilm layer determine the architecture of biofilm", Soft Matter
  6. Engineering a 3D microfluidic culture platform for tumor-treating field application", Scientific Reports
  7. "Mechanical signatures of microbial biofilms in micropillar-embedded growth chambers", Soft Matter
  8. "The polymer physics of single DNA confined in nanochannels" Advances in Colloid and Interface Science
  9. "M2a macrophages induce contact-dependent dispersion of carcinoma cell aggregates", Macrophage

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications