Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.


BioSyM Highlights

In Vivo, Label-free Imaging of liver surface using multi-photon microscopy

BioSyM researchers and collaborators from A*STAR-IBN and NUS have developed a label-free, three-dimensional quantitative and sensitive method to visualize various structural features of liver surface in living rat using multi-photon microscopy (MPM). The work is now published in Applied Physics Letters.

(a) Principle of the TPEF / SHG (two-photon excited fluorescence / Second-harmonic generation) (b) Schematic of the experimental setup.

Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells

Multi-organizational collaborative study among researchers from SMART-BioSyM, NUS, MBI (Mechanobiology Institute), NCCS (National Cancer Centre, Singapore), Clearbridge Biomedics, Sequenom Inc. USA, SGH (Singapore General Hospital), NUH (National University Hospital) has clinically vaildated our multiplexed microfluidic chip for the ultra high-throughput, low-cost and label-free enrichment of CTCs. Retrieved cells were unlabeled and viable, enabling potential propagation and real-time downstream analysis using next generation sequencing (NGS) or proteomic analysis (PloS One, 9(7), e994092014. (2014))

......More BioSyM Highlights








Recent Publications

  1. "In vivo, label-free, three-dimensional quantitative imaging of liver surface using multi-photon microscopy", Applied Physics Letters
  2. "Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells" PLoS One
  3. "Dysregulated sphingolipid metabolism in endometriosis", The Journal of Clinical Endocrinology and Metabolism
  4. “A ratiometric fluorescent molecular probe with enhanced two-photon response upon Zn2+ binding for in vitro and in vivo bioimaging”, Chemical Science
  5. "Application of smoothed continuous labile haemoglobin A1c reference intervals for identification of potentially spurious HbA1c results", Journal of Clinical Pathology
  6. "qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients", Journal of Hepatology
  7. "CD26/DPPIV down-regulation in endometrial stromal cell migration in endometriosis", Fertility and Sterility
  8. "An ultra-high throughput spiral microfluidic biochip for the enrichment of circulating tumor cells", Analyst

    ..........Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications