Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.


BioSyM Highlights

BioSyM's research was displayed at Singapore's 1st Tech Carnival on 25th April 2015 @ Suntech City Tower, as part of SMART's research showcase on healthcare, environment and mobility. The video displayed 4 of BioSyM's projects: Miniaturised Magnetic Resonanance Relaxometry for malaria detection, Bio-Imaging, Microfluics Cell sorter and 3D microfluidics for drug screening

International Media visits SMART BioSyM labs @ CREATE

Biosym hosted a group of International Media for a lab visit on 20th April 2015. BioSyM researcher Dr.Andrea Pavesi and his collaborator from Duke-NUS Dr.Tan Anthony Tanoto described our 3D microfluidic technology and its clinical applications in cancer treatment. Mr.Kuan Chee Mun, CEO of AIM Biotech described his company's path in commercializing BioSyM's technology.


......More BioSyM Highlights









SMART Biosym Seminar by

Dr. Xinghua Zhang, SMART- BioSyM

Diversity of DNA structures under high tension 

Time: Friday, May 15, 2015, 4 pm
Location: SMART Enterprise Level 5, Perseverance Rooms

Recent Publications

  1. "Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy", Oncotarget
  2. "Metastable Knots in Confined Semiflexible Chains", Macromolecules
  3. "Malaria Detection using Inertial Microfluidics", Lab on A Chip
  4. "Improving liver fibrosis diagnosis based on forward and backward second harmonic generation signals", Applied Physics Letters
  5. “Origin of Metastable Knots in Single Flexible Chains”, Physical Review Letters
  6. “Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors From Mesenchymal Stromal Cells”, Stem Cells Translational Medicine
  7. "Jetting microfluidics with size-sorting capability for single-cell protease detection", Biosensors and Bioelectronics
  8. "Phase imaging using shifted wavefront sensor images", Optics Letters

    ..........Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications