Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

Atlas of Science has published our "Layman" summary (titled "Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies”) of our recent article published in drug discovery today

Schematic representation of the tumour microenvironment (TME) and its main constituents that represent a challenge for T cell immunotherapy (left). 3D TME microfluidic models used to study cancer metastasis and tumor-immune system interaction mechanisms (center) represent a preclinical screening platform for T cell immunotherapies.










......More BioSyM Highlights









BioSyM Focused Seminar Series

New Researchers Talk

10 October — 19 December 2016

28th November 2016, Monday, 12-1 pm

Dr.Darwesh MK Aladin (SMART)

E-cadherin's extracellular domains determine key epithelium mechanical phenotypes

Venue: NUS UTown, Enterprise Level 5, Perseverance Room

Recent Publications

  1. "Effects of Intrachain Interactions on the Knot Size of a Polymer", Macromolecules
  2. “Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma”, Oncoimmunology
  3. "Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment", Science Advances
  4. “Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability through effectively inhibiting twisted intramolecular charge transfer”, Journal of American Chemical Society
  5. "Microfluidic models for adoptive cell-mediated cancer immunotherapies", Drug Discovery Today
  6. "Mechanical properties of the superficial biofilm layer determine the architecture of biofilm", Soft Matter
  7. Engineering a 3D microfluidic culture platform for tumor-treating field application", Scientific Reports
  8. "Mechanical signatures of microbial biofilms in micropillar-embedded growth chambers", Soft Matter

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications