Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

BioSyM Alumna Dr.Krishna Agarawal has secured Marie Curie Individual Fellowship. This fellowship carries a research funding over 2 years and she will be applying MUSICAL (Multiple signal classification algorithm) for imaging viruses and bacteria in liver cells. She will carry out her research at University of Tromso, Norway.

STRAITS TIMES reports BioSyM Research: "Singapore-made device to aid in developing cancer therapy"

The device between Dr Pavesi's fingertips is no larger than a stamp but he hopes to use it to explore electric fields and cancer cells. Team member Giulia Adriani is holding the mould used to make the tool.ST PHOTO: LAU FOOK KONG











......More BioSyM Highlights









BioSyM Seminar Series 2017

d’Biomager–A Quantitative Phase Imaging Add-on for Microscopes

Professor Anand ASUNDI (NTU)

20 February 2017, Monday; 4 pm

@ CREATE Tower, Level 2, Theatrette

Cell Advanced Manufacturing & Production


16th January 2017

This symposium discusses the current state-of-art and opportunities for Singapore to become a world leader in cell manufacturing. Biological cell-based therapies offer the potential to improve human health, but require advanced manufacturing technologies and workforces to produce cells and cell-products safely and at scale. This symposium addresses challenges and opportunities in cell and cell-product manufacturing in Singapore and the US. This public symposium includes industry, academic, and government stakeholders in the research, innovation, and enterprise to produce cell products ranging from regenerative stem cells to cancer therapies to vaccines.


13 & 14 January 2017

@ the CREATE THEATRE Level 2, CREATE TOWER, 1, CREATE WAY, Singapore 138602

Recent Publications

  1. "Multiple signal classification algorithm for super-resolution fluorescence microscopy", Nature Communications
  2. "Effects of Intrachain Interactions on the Knot Size of a Polymer", Macromolecules
  3. “Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma”, Oncoimmunology
  4. "Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment", Science Advances
  5. “Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability through effectively inhibiting twisted intramolecular charge transfer”, Journal of American Chemical Society
  6. "Microfluidic models for adoptive cell-mediated cancer immunotherapies", Drug Discovery Today
  7. "Mechanical properties of the superficial biofilm layer determine the architecture of biofilm", Soft Matter
  8. Engineering a 3D microfluidic culture platform for tumor-treating field application", Scientific Reports

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications