In Vivo, Label-free Imaging of liver surface using multi-photon microscopy
BioSyM researchers and collaborators from A*STAR-IBN and NUS have developed a label-free, three-dimensional quantitative and sensitive method to visualize various structural features of liver surface in living rat using multi-photon microscopy (MPM). The work is now published in Applied Physics Letters.
(a) Principle of the TPEF / SHG (two-photon excited fluorescence / Second-harmonic generation) (b) Schematic of the experimental setup.
Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells
Multi-organizational collaborative study among researchers from SMART-BioSyM, NUS, MBI (Mechanobiology Institute), NCCS (National Cancer Centre, Singapore), Clearbridge Biomedics, Sequenom Inc. USA, SGH (Singapore General Hospital), NUH (National University Hospital) has clinically vaildated our multiplexed microfluidic chip for the ultra high-throughput, low-cost and label-free enrichment of CTCs. Retrieved cells were unlabeled and viable, enabling potential propagation and real-time downstream analysis using next generation sequencing (NGS) or proteomic analysis (PloS One, 9(7), e994092014. (2014))