Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.


BioSyM Highlights

World’s first novel method for label-free identification of stem cells that will lead to more consistent and efficacious stem cell therapies

Left Pix: (L-R) Associate Professor Jerry Chan, SMART co-Investigator; Dr Zhiyong Poon, SMART Research Scientist and  Dr Jacky Lee, former SMART Postdoctoral Associate, with the microfluidics cell sorting device that isolates Mesenchymal  Stem Cells (MSCs) for bone and muscle therapeutic applications. This device can reduce the analysis and decision-making  process from 1 - 2 months to less than 3 days. Right Pix: Close-up of the microfluidics cell sorting device.

The research entitled ‘Multivariate biophysical markers predictive of mesenchymal
stromal cell multipotency
’ has been published in the prestigious scientific journal
Proceedings of the National Academy of Sciences.

A new way to diagnose malaria

SMART-BioSyM team has now come up with a possible alternative. The researchers have devised a way to use magnetic resonance relaxometry (MRR), a close cousin of magnetic resonance imaging (MRI), to detect a parasitic waste product in the blood of infected patients. The paper describing the technique in the Aug. 31 issue of Nature Medicine.

SMART- BioSyM Press Release

Worldwide News coverage on our Malaria diagnosis technique

......More BioSyM Highlights










SMART Biosym Mini-Workshop on

Statistical bootstrapping

John M. Maloney, Research Scientist, MIT, Cambridge MA USA

Time: January 30, 2015, 10.30 am - 12 noon
Location: SMART Enterprise Level 5, Perseverance Rooms


SMART Biosym Seminar by

John M. Maloney, Research Scientist, MIT, Cambridge MA USA

Suspended‐cell mechanics: Which chemoenvironmental cues matter? Why are distribution widths so important?

Time: January 29, 2015, 4 pm
Location: SMART Enterprise Level 5, Perseverance Rooms


Recent Publications

  1. “Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors From Mesenchymal Stromal Cells”, Stem Cells Translational Medicine
  2. "Jetting microfluidics with size-sorting capability for single-cell protease detection", Biosensors and Bioelectronics
  3. "Phase imaging using shifted wavefront sensor images", Optics Letters
  4. "Phase imaging for absorptive phase objects using hybrid uniform and structured illumination Transport of Intensity Equation", Optics Express
  5. "In vivo label-free quantification of liver microcirculation using dual-modality microscopy", Journal of Biomedical Optics
  6. Effect of YOYO-1 on the mechanical properties of DNA, Soft Matter
  7. Interconversion between Three Overstretched DNA Structures, Journal of American Chemical Society
  8. Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis, Nucleic Acids Research

    ..........Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications