Singapore-MIT Alliance for Research & Technology

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

  • BioSyM brings together a multidisciplinary team of faculties and researchers from MIT and the Universities and Research Institutes of Singapore. Our research deals with the development of new technologies to address critical medical and biological questions applicable to a variety of diseases. We aim to provide novel solutions to the healthcare industry and to the broader research infrastructure in Singapore.

  • The guiding tenet of BioSyM is that accelerated progress in biology and medicine will critically depend upon the development of modern analytical methods and tools that provide a deep understanding of the interactions between mechanics and biology at multiple length scales – from molecules to cells to tissues – that impact maintenance or disruption of human health.

BioSyM Highlights

SMART-BioSyM start-up, AIM Biotech's microfluidics device (shown here) has an array of culturing sections, each with three chambers: a middle chamber for hydrogel and any cell type, and two side channels for culturing additional cell types.

Spinout’s microfluidics device better models how cancer and other cells interact in the body:

BioSyM - A*STAR - NUS researchers develop microfluidic "in vitro" platform to study Tumor Associated Macrophages (TAMs)

Researchers from SMART-BioSyM and A*STAR Institutes SIgN and IMCB have developed a novel microfluidic based in vitro tumor microenvironment. This platform was utilized to study the role of individual subtypes of macrophages (M0, M1, M2a, M2b and M2c) in human lung adenocarcinoma (A549) aggregate dispersion, as a representation of epithelial- mesenchymal transition (EMT). The findings may help in the development of immunotherapies based on enhancing the tumor-suppressive properties of TAMs. The results are now published in Oncotarget.

Membrane-less microfiltration using inertial microfluidics

BioSyM researchers have developed a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achieve a macroscopic volume processing rates (~ 500 mL/min). This platform has the desirable combinations of high throughput, low-cost, and scalability, making it compatible for a myriad of microfiltration applications and industrial purposes. The details are described in Scientific Reports (Nature Publishing) 5, 11018 (2015)


Controlled electrical, mechanical and biochemical stimulation of Cells on a chip

BioSyM researchers describe in a new publication in Scientific Reports (Nature Publishing) 5, 11800 (2015), the design and fabrication of a microfluidic device capable of simultaneously providing mechanical, electrical, and biochemical stimulation, and subsequently extracting detailed morphological and gene-expression analysis on the cellular response.


......More BioSyM Highlights









BioSyM Seminar

Ms Tan Ying Ying

Senior Product Manager, Fisher Scientific

Proper Pipetting and Pipetting Ergonomics

Time: Monday, August 24, 2015, 4 pm
Location: CREATE Enterprise Level 5, Perseverance Rooms


Recent Publications

  1. "Single-Particle Spectroscopic Study on Fluorescence Enhancement by Plasmon Coupled Gold Nanorod Dimers Assembled on DNA Origami", J. Phys. Chem. Lett.
  2. "Chaos analysis of viscoelastic chaotic flows of polymeric fluids in a micro-channel", AIP ADVANCES
  3. "Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions", Oncotarget
  4. "Membrane-less microfiltration using inertial microfluidics", Scientific Reports (Nature Publishing)
  5. "Controlled electromechanical cell stimulation on-a-chip" Scientific Reports (Nature Publishing)
  6. "Enhancing malaria diagnosis through microfluidic cell enrichment and magnetic resonance relaxometry detection", Scientific Reports (Nature Publishing)
  7. "Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy", Oncotarget
  8. "Metastable Knots in Confined Semiflexible Chains", Macromolecules

    ...................Publications (Full List)

Our people

Meet the Principal Investigators, Collaborators, researchers, students and staff of SMART-BioSyM

Our research

Read about our research thrusts/projects, lab facilities and publications