SMART - Singapore MIT Alliance for Research and Technology

Singapore-MIT Alliance for Research & Technology

Biosystems and Micromechanics

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

Patrick S. Doyle
Professor of Chemical Engineering, MIT


  • 2006- Associate Professor of Chemical Engineering, M.I.T.
  • 2000-2006 Assistant Professor of Chemical Engineering, M.I.T.
  • 1997-2000 Postdoctoral Research Associate, Institute Curie


  • Soft Matter Lectureship Award, 2012
  • Joliot Chair, ESPCI, 2009
  • John Simon Guggenheim Fellowship, 2009
  • Rothschild-Yvette Mayent-Institute Curie Award, 2009
  • Van Ness Lectures at RPI, 2008
  • Lab on a Chip, Royal Society of Chemistry and Corning Inc., Pioneers of Miniaturization Prize, 2008
  • Henry L. and Grace Doherty Professorship, 2005-2007
  • University of Notre Dame Thiele Lectureship, 2006
  • U of DE Colburn Memorial Lecture, 2006
  • NSF-CAREER Award, 2003
  • 3-M Innovation Fund Award,2003
  • Polypops Innovation Award, 2001
  • Fondation de la Recherche Medical Postdoctoral Grant, 1999-2000
  • Institut Curie Postdoctoral Fellowship, 1998-1999
  • Chateaubriand Fellowship, 1997-1998
  • Stanford University's Lieberman Fellowship, 1996-1997

Selected peer-reviewed publications

  • Zhang, X., Chen, H., Fu, H., Doyle, P.S., and Yan, J., "Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements", Proc. Natl. Acad. Sci., DOI:10.1073/pnas.1109824109, 2012.
  • Zhang, C., Gong, Z., Guttula, D., Malar, P., van Kan, J., Doyle, P.S., and van der Maarel, J., "Nanofluidic Compaction of DNA by Like-Charge Protein", J. Phys. Chem. B, 116, (2012)   
  • Pregibon D, Toner M, Doyle PS. Multi-functional Encoded Particles for High-Throughput Biomolecule Analysis. Science, 2007; 315:1393-96.
  • Kim JM, Doyle PS. Design and numerical simulation of a DNA electrophoretic stretching device. Lab on Chip. 2007; 7(2):213-25.
  • Balducci A, Hsieh C-C, Doyle PS. Relaxation of DNA in slit-like confinement. Phys. Rev. Lett. 2007; 99:238102.
  • Tang J, Doyle PS. Electrophoretic stretching of DNA molecules using microscale T-junctions. Appl. Phys. Lett. 2007; 90:224103.
  • Dendukuri D, Pregibon DC, Collins J, Hatton TA, Doyle PS. Continuous Flow Lithography for High-Throughput Microparticle Synthesis. Nat. Mater. 2006; 5:365-69.
  • Doyle PS, Bibette J, Bancaud A, Viovy JL. Self-Assembled Magnetic Matrices for DNA Separation in Lab on a Chip. Science. 2002; 295:227.

Current research support

  • NSF (PI) DNA Polymer Dynamics in Nanoconfinement(2009-12)
  • Singapore-MIT Alliance (co-PI) Chemical and Pharmaceutical Engineering (2008-12)