SMART - Singapore MIT Alliance for Research and Technology

Singapore-MIT Alliance for Research & Technology

Biosystems and Micromechanics

BioSystems and Micromechanics (BioSyM) Inter-Disciplinary Research Group

ZHANG Xinghua
Post-Doctoral Associate, BioSystems & Micromechanics IRG, Singapore-MIT Alliance For Research and Technology (SMART)


  • 2004 – 2009; Ph.D. Condensed Matter Physics, Chinese Academy of Sciences, China
  • 2000 – 2004; BSc. Physics, Shandong University, China


  • 2010 – Present; Postdoctoral Associate, Department of Biological Engineering, MIT & BioSyM, SMART
  • 2009 – 2010; Patent Examiner, State Intellectual Property Office, China

Research Interest

  • Interactions between DNA and Intercalators Using Single Molecule Manipulation
  • Interactions between DNA and Anticancer Drugs Using Single Molecule Manipulation

Honors and Awards

  • Outstanding  Student Award in Institute of Physics, 2008


  • Zhang Xinghua (SMART), Chen H (MBI), Le S (MBI), Rouzina I (Univ. Minnesota, USA), Doyle P.S. (MIT/SMART), and Yan J (NUS/MBI)., "Revealing the Competition between Peeled-ssDNA, Melting Bubbles and S-DNA during DNA Overstretching by Single-Molecule Calorimetry", Proc. Natl. Acad. Sci., published online (Feb 2013)
  • Xinghua Zhang (SMART), Hu Chen (MBI/NUS), Hongxia Fu (MBI/NUS), Patrick S. Doyle (MIT/SMART) and Jie Yan (NUS), "Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements", PNAS, 2012, published online on April 24, 2012
  • X. Zhang (SMART), H. Fu, P.S. Doyle (MIT/SMART), and J.Yan (NUS), "Temperature dependence of two distinct DNA overstretching transitions", APS March Meeting, March 2011; Dallas, TX  USA.
  • Xi-Miao Hou, Xing-Hua Zhang, Kong-Ji Wei, Chao Ji, Shuo-Xing Dou, Wei-Chi Wang, Ming Li , Peng-Ye Wang, “Cisplatin induces loop structures and condensation of single DNA molecules”, Nucleic. Acids. Res., 37(5), 1400-1410 (2009).
  • Xing-Hua Zhang, Bin Xiao, Xi-Miao Hou, Chun-Hua Xu, Peng-Ye Wang, Ming Li, “Study of Cisplatin-Induced DNA Compaction Using Single Molecule Magnetic-tweezers”, Acta Physica Sinica, 58(6), 4301-4306 (2009).
  • Xiao-Ling Wang, Xing-Hua Zhang, Meiwen Cao, Hai-Zi Zheng, Bin Xiao, Yilin Wang , Ming Li, “Gemini Surfactant-Induced DNA Condensation into a Beadlike Structure” J. Phys. Chem. B, 113 (8), 2328–2332 (2009).
  • Xing-Hua Zhang, Xi-Miao Hou, Chao Ji, Ming Li , Peng-Ye Wang, “Spermidine-Induced Two Dimensional DNA Condensation on Mica Surface: A Different Pathway from the Condensation in Solution”, Chinese Science Bulletin, 54(14), 2425-2433 (2009).
  • Bo Sun, Kong-Ji Wei, Bo Zhang, Xing-Hua Zhang, Shuo-Xing Dou, Ming Li1, Xu Guang Xi, “Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding” EMBO J., 27(24), 3279-3287 (2008).
  • Xiao-Ling Wang, Xing-Hua Zhang, Kong-Ji Wei, Bo Sun, Ming Li, “An Improved Single Molecule Manipulation Apparatus and Its Applications”, Acta Physica Sinica, 56(6), 3905-3911 (2008).
  • Wen-Bo Fu, Xiao-Ling Wang, Xing-Hua Zhang, Shi-Yong Ran, Jie Yan, Ming Li, “Compaction Dynamics of Single DNA Molecules under Tension”, J. Am. Chem. Soc., 128(47), 15040-15041 ( 2006).