EpiPred

Identifying HLA-DR Binding Epitopes

* Use the EpiPred links below to open spreadsheets containing formulas for the listed alleles

* WARNING: The EpiPred windows are slow and clumsy. Please be patient. EpiPred30 is the fastest file listed.

* ATTENTION: Best viewed (only viewable?) in Internet Explorer.
 
 

SPREADSHEET NAME
MAX # AA's
EMPIRICAL MATRICES
VIRTUAL MATRICES
EpiPred30
30
Hammer DR1, DR4; Sette DR1, DR4
all alleles listed below
EpiPred50
50
Hammer DR1, DR4; Sette DR1, DR4
all alleles listed below
EpiPredDR1
1000
Hammer DR1; Sette DR1
B1*0101
EpiPredDR4
1000
Hammer DR4; Sette DR4
B1*04xx
EpiPredCommon
200
Hammer DR1, DR4
B1*0101, B1*0301, B1*0401/02/04/05, B1*0701, 
B1*0802, B1*1101, B1*1301, B1*1501, B5*0101
EpiPred1
200
Hammer DR1, DR4; Sette DR1, DR4
B1*01xx, B1*03xx, B1*15xx, B5*01xx
EpiPred2
200
  
B1*04xx, B1*07xx, B1*08xx
EpiPred3
200
  
B1*11xx, B1*13xx
**Matrices**
N/A
Contains the matrices used to compute the data for all the alleles
  

References:
Hammer Algorithms    Hammer, et al., JExMed '94, 180:2353
Sette Algorithms    Southwood, et al., JI '98, 160:3363-73
Virtual Matrices    Sturniolo, et al., Nat Biotech,  '99, 17:555-61.

Note:  The "Hammer DR1" matrix is actually the P1/2/3 values from the Hammer DR4
matrix and the P4/6/7/9 values from the Virtual DR1 matrix.

In our experience, the Hammer algorithms are better than the Sette ones.

Original spreadsheet designed by Thomas O. Cameron while at MIT, Dept. of Chemistry.
Surely this is not the best way to publish these algorithms on the internet, but I'm no web-geek.
Source "code" spreadsheet available on request.  Contact Larry Stern or Tom Cameron (tomcameron@alum.mit.edu).

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