Positions available
Postdoctoral Research Opportunity
U.S. Food & Drug Administration/National Center for Toxicological Research.
Laboratory: U.S. Food & Drug Administration/National Center for Toxicological Research.
Web Site: http://www.fda.gov/NCTR/
Availability: Immediate
Description: A position is immediately available for a postdoctoral researcher to conduct mechanistic studies on the genotoxicity and metabolic biomarkers of furan, a carcinogenic cooking byproduct found in many common foods. The successful candidate will need strong organic synthetic skills to prepare and characterize DNA adducts, peptide adducts, and urinary metabolites. This position will provide an excellent opportunity to master qualitative and quantitative aspects of modern atmospheric pressure ionization mass spectrometry and to use such measurements for metabolomic-based biomonitoring to improve cancer risk assessment. The successful candidate will be supported by strong instrumental resources, including 3 triple quadrupole mass spectrometers and a hybrid Q-Tof/ion mobility spectrometer, all equipped with UPLCs.
Qualifications: An earned Ph. D. in Toxicology, Biochemistry, Chemistry, or equivalent is required. Experience in carcinogen metabolism, chromatographic separations, and mass spectrometry is desirable. The position is available to U.S. citizens/residents and foreign nationals who qualify for J-visa status.
Salary: The position is renewable for up to 3 years with a starting stipend of $54,494.
Contact: To apply, briefly describe research goals and submit a curriculum vitae including a list of three professional references with their contact information to:
Dr. Daniel R. Doerge
Division of Biochemical Toxicology
3900 NCTR Road
Jefferson, AR 72079
email, Daniel.doerge@fda.hhs.gov
tel 870-543-7943.
Posted on: April 20, 2008
Postdoctoral Position
Polycyclic Aromatic Hydrocarbon Carcinogenesis
Laboratory: Dr Trevor Penning at the University of Pennsylvania
Lab Web Site: www.med.upenn.edu/pharm/faculty/penning/penning.html
Availability: Immediate
Description: Training available to join a multi-investigator team to elucidate pathways of polycyclic aromatic hydrocarbon (PAH) metabolism and activation in human lung bronchial epithelial cells. PAH are ubiquitous environmental pollutants and known suspect carcinogens in tobacco smoke. The candidate will conduct metabolism studies using stable-isotope dilution LC/MS methods using benzo[a]pyrene as a representative PAH. Metabolic profiles will be phenotyped based on enzyme expression of major gene superfamilies e.g. P450 isoforms and aldo-keto reductases (AKRs). Emphasis will also be placed on detecting oxidative DNA damage that may arise from the production of quinones mediated by AKRs. The training is supported by an R01 from the National Institutes of Health and funding is available for 1 - 5 years.
For More Information Visit:
www.med.upenn.edu/akr and
www.med.upenn.edu/ceet
Qualifications: Recent Ph.D. in biochemistry, toxicology or drug metabolism desirable. Prior expertise in one or more for the following areas desirable: enzymology, analytical chemistry (RP-HPLC, LC/MS), mammalian cell culture, metabolism using radiotracers, and spectral identity of unknowns desirable.
Contact: Please forward a cover letter, an updated c.v. including a list of your publications, and the names/addresses of 3 references to:
TREVOR PENNING, Ph.D.
Director Center of Excellence in Environmental Toxicology
Department of Pharmacology
University of Pennsylvania School of Medicine
130C John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6084
penning@pharm.med.upenn.edu
Posted on: Dec 6, 2007
At what point do innovations become therapies?
Pharmacokinetics, Dynamics, and Metabolism
Company: Pfizer Pharmacokinetics, Dynamics, and Metabolism
Company's URL: www.pfizerdrugmetabolism.com
Availability: Immediate
Synopsis:
At Pfizer Global Research & Development (PGRD), we're not content waiting to witness the evolution of our industry. Instead, we're driven by science, building on our current successes and capabilities, playing a critical role in developing the most compelling story of scientific discoveries.
Our research pipeline spans many therapeutic areas and to date we've brought to market such outstanding medicines as Lipitor, Chantix, Sutent, Lyrica, Exubera, and Viagra. And in the future we'll bring many more therapies and cures to the marketplace, making the world a healthier place for all.
Pfizer Pharmacokinetics, Dynamics, and Metabolism (PDM) is the largest drug metabolism and pharmokinetics group in the world. With over $100 MM per year invested in the latest research and technology, PDM plays a critical part in both drug discovery and drug development - its primary role being the characterization of the effects of the body on potential drug entities ranging from chemically synthesized small molecules to biologically derived macromolecules. Core competencies include: in vitro and in vivo ADME research (transporters and metabolism), biologics research, bioanalytical science and automation, PK/PD modeling and biomarkers, and in silico and
computational modeling.
But there is much more work to be done and we can't do it alone. That's why we're always seeking those who share our belief that science can improve our world, that by working together we can bring exciting new therapies to patients on a global scale and forever change the way we improve the health and well-being of all people.
Now you can be a vital member of a research and development company unlike any other, Pfizer Global Research & Development. Join us and use your talents to turn innovations into therapies.
To learn more about our people, our products, and our plans for the future, visit www.pfizerdrugmetabolism.com
We're proud to be an equal opportunity employer and welcome applications from people with different experiences, backgrounds and ethnic origins.
Posted on: Aug 24, 2007
Web sites of interest for Chemical Toxicology job seekers
American Association for the Advancement of Science
An article in Science Magazine highlights Career Opportunities in Toxicology. Visit Opportunities Abound in Toxicology, by Brian Vastag
Society of Toxicology
The SOT website has a valuable Resource Guide to Careers in Toxicology
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