Positions available
Cancer Biology and Chemotherapy Development
Postdoctoral Research Opportunity
Laboratory: Dr Paul Henderson, UC Davis Medical Center
Description: A postdoctoral position is available in cancer biology and chemotherapy development. The successful applicant will be expected to apply a novel mass spectrometry tool for understanding the mechanisms of platinum (Pt) drug resistance in variety of tumor cell types. Multiple studies have correlated chemoresistance with Pt bound to DNA (Pt-DNA adducts are the main cause of cell killing by this class of drugs). However, the technologies used in those studies are not sensitive enough for diagnostic applications and require patients to receive toxic high-dose chemotherapy before chemoresistance can be identified. We recently developed a highly sensitive accelerator mass spectrometry (AMS) assay for carboplatin-DNA adduct detection. AMS has attomole (10-18 mole) sensitivity for 14C isotope labels. AMS is approximately 1,000-fold more sensitive than other technologies for detection of DNA adducts caused by the widely prescribed drug carboplatin. With AMS, we were able to detect cellular drug uptake and Pt-DNA adduct formation in cell culture and in mouse tumors that were exposed to [14C]carboplatin microdoses (1/100th the therapeutic dose). Importantly, the area-under-the-curve for carboplatin-DNA adduct formation correlated with drug sensitivity for each tumor type tested, which supports the potential clinical application of the technology. We seek a postdoctoral fellow to continue cell culture, mouse and clinical studies of the application of AMS to chemoresistance mechanisms and oncology diagnostics.
Qualifications: The applicant must have a Ph.D. and/or M.D. in molecular biology, biochemistry, or related field, with practical laboratory experience. Other preferred qualifications include experience in HPLC and clinical feasibility studies. We are looking for an individual who is able to design and conduct experiments independently. The candidate should have good communication skills and the ability to supervise as well as train students in the laboratory. The successful candidate is expected to prepare and submit manuscripts to peer-reviewed journals, and participate in seminars and weekly lab meetings.
Contact: Applicants should submit a curriculum vitae, including list of publications, a description of their present research activity and scientific goals along with contact information for three referees to: Dr. Paul T. Henderson (phenderson@ucdavis.edu).
Posted on: August 26, 2008
Molecular Biology and Nanotechnology for Cell Signaling Studies
Postdoctoral Research Opportunity
Laboratory: Dr Paul Henderson, UC Davis Medical Center
Web Site:
Description: A postdoctoral position is immediately available in molecular biology and nanotechnology for cell signaling studies. The successful applicant will be expected to apply novel proteomic tools for understanding the mechanisms of action for G-protein coupled receptors and human epidermal growth factors that are important in signal transduction and the etiology of cancer. We have developed cell-free expression methods for producing and isolating G-coupled receptors in nanoparticles that simulate the cellular lipid bilayer environment. Applications for this technology include drug development, receptor biochemistry and mechanistic analysis of early signaling events. This work will also involve the biophysical characterization of these protein complexes in collaboration with the NSF Center for Biophotonics at U.C. Davis
Qualifications: Ph.D. and/or M.D. in molecular biology, biochemistry, or related field, with practical laboratory experience. Other preferred qualifications include experience in biophysical techniques. We are looking for an individual who is able to design and conduct experiments independently. The candidate should have good communication skills and the ability to supervise as well as train students in the laboratory. The successful candidate is expected to prepare and submit manuscripts to peer-reviewed journals, and participate in seminars and weekly lab meetings. .
Contact: Applicants should submit a curriculum vitae, including list of publications, a description of their present research activity and scientific goals along with contact information for three referees to: Dr. Paul T. Henderson (phenderson@ucdavis.edu) and Dr. Matthew A. Coleman (coleman16@llnl.gov)
Posted on: August 26, 2008
Postdoctoral Research Opportunity
Nucleoside, Phosphoramidite, and Oligodeoxynucleotide synthesis
Laboratory: Dr Natalia Tretyakova, Ph.D, at the University of Minnesota
Web Site: http://www.pharmacy.umn.edu/faculty/tretyakova_natalia/home.html
Availability: Immediate
Description: A postdoctoral position is available for an individual with a Ph.D. in Medicinal Chemistry or a related field to investigate the effects of C-5 cytosine substitution on reactivity of neighboring guanine bases towards carcinogen metabolites. The work will involve synthesis of structural analogs of cytosine and their incorporation into DNA by phosphoramidite chemistry, structural characterization of modified DNA duplexes, and investigation of their reactivity towards carcinogen metabolites using mass spectrometry techniques.
Qualifications: Ph.D. in Organic Chemistry with practical knowledge of nucleoside, phosphoramidite, and oligodeoxynucleotide synthesis and previous experience or interest in biological mass spectrometry.
Contact:
Natalia Tretyakova, Ph.D.
Associate Professor of Medicinal Chemistry
University of Minnesota
Tel. 612-626-3432
e-mail trety001@umn.edu
Posted on: August 26, 2008
Postdoctoral Research Opportunity
U.S. Food & Drug Administration/National Center for Toxicological Research.
Laboratory: U.S. Food & Drug Administration/National Center for Toxicological Research.
Web Site: http://www.fda.gov/NCTR/
Availability: Immediate
Description: A position is immediately available for a postdoctoral researcher to conduct mechanistic studies on the genotoxicity and metabolic biomarkers of furan, a carcinogenic cooking byproduct found in many common foods. The successful candidate will need strong organic synthetic skills to prepare and characterize DNA adducts, peptide adducts, and urinary metabolites. This position will provide an excellent opportunity to master qualitative and quantitative aspects of modern atmospheric pressure ionization mass spectrometry and to use such measurements for metabolomic-based biomonitoring to improve cancer risk assessment. The successful candidate will be supported by strong instrumental resources, including 3 triple quadrupole mass spectrometers and a hybrid Q-Tof/ion mobility spectrometer, all equipped with UPLCs.
Qualifications: An earned Ph. D. in Toxicology, Biochemistry, Chemistry, or equivalent is required. Experience in carcinogen metabolism, chromatographic separations, and mass spectrometry is desirable. The position is available to U.S. citizens/residents and foreign nationals who qualify for J-visa status.
Salary: The position is renewable for up to 3 years with a starting stipend of $54,494.
Contact: To apply, briefly describe research goals and submit a curriculum vitae including a list of three professional references with their contact information to:
Dr. Daniel R. Doerge
Division of Biochemical Toxicology
3900 NCTR Road
Jefferson, AR 72079
email, Daniel.doerge@fda.hhs.gov
tel 870-543-7943.
Posted on: April 20, 2008
At what point do innovations become therapies?
Pharmacokinetics, Dynamics, and Metabolism
Company: Pfizer Pharmacokinetics, Dynamics, and Metabolism
Company's URL: www.pfizerdrugmetabolism.com
Availability: Immediate
Synopsis:
At Pfizer Global Research & Development (PGRD), we're not content waiting to witness the evolution of our industry. Instead, we're driven by science, building on our current successes and capabilities, playing a critical role in developing the most compelling story of scientific discoveries.
Our research pipeline spans many therapeutic areas and to date we've brought to market such outstanding medicines as Lipitor, Chantix, Sutent, Lyrica, Exubera, and Viagra. And in the future we'll bring many more therapies and cures to the marketplace, making the world a healthier place for all.
Pfizer Pharmacokinetics, Dynamics, and Metabolism (PDM) is the largest drug metabolism and pharmokinetics group in the world. With over $100 MM per year invested in the latest research and technology, PDM plays a critical part in both drug discovery and drug development - its primary role being the characterization of the effects of the body on potential drug entities ranging from chemically synthesized small molecules to biologically derived macromolecules. Core competencies include: in vitro and in vivo ADME research (transporters and metabolism), biologics research, bioanalytical science and automation, PK/PD modeling and biomarkers, and in silico and
computational modeling.
But there is much more work to be done and we can't do it alone. That's why we're always seeking those who share our belief that science can improve our world, that by working together we can bring exciting new therapies to patients on a global scale and forever change the way we improve the health and well-being of all people.
Now you can be a vital member of a research and development company unlike any other, Pfizer Global Research & Development. Join us and use your talents to turn innovations into therapies.
To learn more about our people, our products, and our plans for the future, visit www.pfizerdrugmetabolism.com
We're proud to be an equal opportunity employer and welcome applications from people with different experiences, backgrounds and ethnic origins.
Posted on: Aug 24, 2007
Web sites of interest for Chemical Toxicology job seekers
American Association for the Advancement of Science
An article in Science Magazine highlights Career Opportunities in Toxicology. Visit Opportunities Abound in Toxicology, by Brian Vastag
Society of Toxicology
The SOT website has a valuable Resource Guide to Careers in Toxicology
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