Sequence information & evolution

1. Elements of population Genetics:

  • Mutations, Fitness, selection
  • Fixation
2. Mathematical tools:
  • Transition probability matrix; approach to steady state
  • Master equation
  • Forward and backward Kolmogorov equations
  • Mean first passage time

Thursday September 10
L1: (MK) Introduction and  (LM) Elements of population genetics

Tuesday September 15
L2: (MK) Evolving probabilities

Thursday  September 17
L3: (LM) Fitness landscapes

Tuesday  September 22
L4: (MK) Forward Kolmogorov equation

Thursday  September 24
L5: (MK) Backward Kolmogorov equation

Tuesday September 29
L6: (LM) Evolutionaty biology of cancer


lec1- Sequence