Macromolecular Structure

1. Introduction to polymers:

  • Entropy and elasticity
  • Interactions and the coil-globule transition
  • Simple lattice models of protein folding
  • Random Energy Model for freezing
2. Protein folding:
  • Role of hydrophobicity and other interactions
  • Secondary structure elements:    alpha-helices & beta-sheets
  • Classification of protein structures, and their evolution
  • Dynamics of fast folding
3. DNA and RNA:
  • Watson-Crick pairing
  • Energy/entropy considerations, and DNA melting
  • RNA secondary structures
  • Hartree equation for obtaining secondary structures without pseudo-knots

Thursday  October 1
L7: (LM)  Froces and Protein structure and folding

Tuesday  October 6
L8: (MK) Phases of polymers

Thursday  October 8
L9: (MK) Compact polymers and REM

Thursday October 15
L10: (MK)  DNA

Tuesday  October 20
L11: (MK)  RNA

Thursday October 22
L12: (HP)  Rouse model


lec1- Structure