Sharp Lab
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Search for Sharp lab publications in Pubmed. . .

Publications 2001 - Present

Garg S, Sharp PA. GENE EXPRESSION. Single-cell variability guided by microRNAs. Science. 2016 Jun 17;352(6292):1390-1. doi: 10.1126/science.aag1097. PubMed PMID: 27313022. PubMed Link

Gosline SJ, Gurtan AM, JnBaptiste CK, Bosson A, Milani P, Dalin S, Matthews BJ, Yap YS, Sharp PA, Fraenkel E. Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements. Cell Rep. 2016 Jan 12;14(2):310-9. PubMed Link

Boutz PL, Bhutkar A, Sharp PA. Detained introns are a novel, widespread class of post-transcriptionally spliced introns. Genes Dev. 2015 Jan 1;29(1):63-80. Pubmed link

Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis. Cell. 2015 Mar 12;160(6):1246-60. Pubmed link

Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. JAMA. 2015 Mar 24-31;313(12):1207-8. doi: 10.1001/jama.2015.1241. PubMed link

Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. In vivo genome editing using Staphylococcus aureus Cas9. Nature. 2015 Apr 9;520(7546):186-91. PubMed link

Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA. Transcription factor trapping by RNA in gene regulatory elements. Science. 2015 Nov 20;350(6263):978-81.PubMed link

Bosson AD, Zamudio JR, Sharp PA. Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition. Mol Cell. 2014 Nov 6;56(3):347-59. Pubmed link

Chen S, Xue Y, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA. Global microRNA depletion suppresses tumor angiogenesis. Genes Dev. 2014 May 15;28(10):1054-67. Pubmed link

Jangi M, Boutz PL, Paul P, Sharp PA. Rbfox2 controls autoregulation in RNA-binding protein networks. Genes Dev. 2014 Mar 15;28(6):637-51. Pubmed link

Jangi M, Sharp PA. Building Robust Transcriptomes with Master Splicing Factors. Cell. 2014 Oct 23;159(3):487-498. Pubmed link

Wu X, Kriz AJ, Sharp PA. Target specificity of the CRISPR-Cas9 system. Quant Biol. 2014 Jun;2(2):59-70. Pubmed link

Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol. 2014 Jul;32(7):670-6. Pubmed link

Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014 Oct 16;514(7522):380-4. Pubmed link

Zamudio JR, Kelly TJ, Sharp PA. Argonaute-bound small RNAs from promoter-proximal RNA polymerase II. Cell. 2014 Feb 27;156(5):920-34. Pubmed link

Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature. 2013 Jul 18;499(7458):360-3. Pubmed link

Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA. Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes Dev. 2013 Apr 15;27(8):941-54. Pubmed link

Gurtan AM, Sharp PA. The Role of miRNAs in Regulating Gene Expression Networks. J Mol Biol. 2013 Mar 13. [Epub ahead of print]. Pubmed link

Leung AK, Sharp PA. Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. Adv Exp Med Biol. 2013;768:165-82. Pubmed link

Wilusz JE, Sharp PA. Molecular biology. A circuitous route to noncoding RNA. Science. 2013 Apr 26;340(6131):440-1. Pubmed link

Wu X, Sharp PA. Divergent transcription: a driving force for new gene origination? Cell. 2013 Nov 21;155(5):990-6. Pubmed

Ebert MS, Sharp PA. Roles for microRNAs in conferring robustness to biological processes. Cell. 2012 Apr 27;149(3):515-24. Pubmed link

Goldberg MS, Sharp PA. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med. 2012 Feb 13;209(2):217-24. Pubmed link

Gurtan AM, Lu V, Bhutkar A, Sharp PA. In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. RNA. 2012 Jun;18(6):1116-22. Pubmed link

Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 2012 Jun 12;21(6):848-55. Pubmed link

Wilusz JE, Jnbaptiste CK, Lu LY, Kuhn CD, Joshua-Tor L, Sharp PA. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes Dev. 2012 Nov 1;26(21):2392-407. Pubmed link

Flynn RA, Almada AE, Zamudio JR, Sharp PA. Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10460-5. Pubmed link

Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):745-50. Pubmed link

Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm. Mol Cell. 2011 May 20;42(4):489-99. Pubmed link

Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.Nat Struct Mol Biol. 2011 Feb;18(2):237-44. Pubmed link

Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. Nat Genet. 2011 Aug 21;43(9):854-9. Pubmed link

Sharp PA, Langer R. Research agenda. Promoting convergence in biomedical science. Science. 2011 Jul 29;333(6042):527. Pubmed link

Wilusz JE, Whipple JM, Phizicky EM, Sharp PA. tRNAs marked with CCACCA are targeted for degradation.Science. 2011 Nov 11;334(6057):817-21. Pubmed link Full text link

Zheng GX, Ravi A, Calabrese JM, Medeiros LA, Kirak O, Dennis LM, Jaenisch R, Burge CB, Sharp PA. A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. PLoS Genet. 2011 7(5):e1002054. Pubmed link

Zheng GX, Ravi A, Gould GM, Burge CB, Sharp PA. Genome-wide impact of a recently expanded microRNA cluster in mouse. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15804-9. Pubmed link

Ebert MS, Sharp PA. Emerging roles for natural microRNA sponges. Curr Biol. 2010 Oct 12;20(19):R858-61. Pubmed link

Ebert MS, Sharp PA. MicroRNA sponges: progress and possibilities. RNA. 2010 Nov;16(11):2043-50. Pubmed link

Leung AK, Sharp PA. MicroRNA functions in stress responses. Mol Cell. 2010 Oct 22;40(2):205-15. Pubmed link

Tsang JS, Ebert MS, van Oudenaarden A. Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol Cell. 2010 Apr 9;38(1):140-53. Pubmed link

Agrawal A, Min DH, Singh N, Zhu H, Birjiniuk A, von Maltzahn G, Harris TJ, Xing D, Woolfenden SD, Sharp PA, Charest A, Bhatia S. Functional delivery of siRNA in mice using dendriworms. ACS Nano. 2009 Sep 22;3(9):2495-504. Pubmed link

Kleppner D, Sharp PA. Research data in the digital age. Science. 2009 Jul 24;325(5939):368. Pubmed link

Seila AC, Core LJ, Lis JT, Sharp PA. Divergent transcription: A new feature of active promoters. Cell Cycle. 2009 Aug 19;8(16). Pubmed link

Sharp PA. The centrality of RNA. Cell. 2009 Feb 20;136(4):577-80. Pubmed link

Grishok A, Hoersch S, Sharp PA. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20386. Pubmed link

Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A. 2008. Pubmed link

Neilson JR, Sharp PA. Small RNA regulators of gene expression. Cell. 2008 Sep 19;134(6):899. Pubmed link

Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science. 2008 Jun 20;320(5883):1643-7. Pubmed link

Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA. Divergent Transcription from Active Promoters. Science. 2008 Dec 19;322(5909):1849. Pubmed link

Seila AC, Sharp PA. Small RNAs tell big stories in Whistler. Nat Cell Biol. 2008 Jun;10(6):630-3. Pubmed link

Aleman LM, Doench J, Sharp PA.Comparison of siRNA-induced off-target RNA and protein effects. RNA. 2007 Mar;13(3):385-95. Pubmed link

Calabrese JM, Seila AC, Yeo GW, Sharp PA. RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2007 104:18097-102. Pubmed link

Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods. 2007 Sep;4(9):721-6. Pubmed link

Leung AK, Sharp PA. microRNAs: A Safeguard against Turmoil? Cell. 2007 Aug 24;130(4):581-5. Pubmed link

Neilson JR, Zheng GX, Burge CB, Sharp PA. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 2007 Mar 1;21(5):578-89. Pubmed link

Calabrese JM, Sharp PA. Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells. RNA. 2006 Dec;12(12):2092-102. Pubmed link

Cheng C, Yaffe MB, Sharp PA. A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev. 2006 Jul 1;20(13):1715-20. Pubmed link

Cheng C, Sharp PA. Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol. 2006 Jan;26(1):362-70. Pubmed link

Leung AK, Calabrese JM, Sharp PA. Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18125-30. Pubmed link

Leung AK, Sharp PA. Function and Localization of MicroRNAs in Mammalian Cells.Cold Spring Harb Symp Quant Biol. 2006;71:29-38. Pubmed link

Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Mol Cell. 2006 Feb 17;21(4):533-42. Pubmed link

Grishok, A. RNAi mechanisms in Caenorhabditis elegans. FEBS Lett. 2005 Oct 31;579(26):5932-9. Pubmed link

Grishok A, Sharp PA. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17360-5. Pubmed link

Grishok A, Sinskey JL, Sharp PA. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev. 2005 Mar 15;19(6):683-96. Pubmed link

Houbaviy HB, Dennis L, Jaenisch R, Sharp PA. Characterization of a highly variable eutherian microRNA gene. RNA. 2005 Aug;11(8):1245-57. Pubmed link

Tantin D, Schild-Poulter C, Wang V, Hache RJ, Sharp PA. The octamer binding transcription factor Oct-1 is a stress sensor. Cancer Res. 2005 Dec 1;65(23):10750-8. Pubmed link

Doench JG, Sharp PA. Specificity of microRNA target selection in translational repression. Genes Dev. 2004 Mar 1;18(5):504-11. Pubmed link

Fairbrother WG, Holste D, Burge CB, Sharp PA. Single nucleotide polymorphism-based validation of exonic splicing enhancers. PLoS Biol. 2004 Sep;2(9):E268. Pubmed link

Fairbrother WG, Yeo GW, Yeh R, Goldstein P, Mawson M, Sharp PA, Burge CB. RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W187-90. Pubmed link

Lee KB, Sharp PA. Transcription-dependent polyubiquitination of RNA polymerase II requires lysine 63 of ubiquitin. Biochemistry. 2004 Dec 7;43(48):15223-9. Pubmed link

Tantin D, Tussie-Luna MI, Roy AL, Sharp PA. Regulation of immunoglobulin promoter activity by TFII-I class transcription factors. J Biol Chem. 2004 Feb 13;279(7):5460-9. Pubmed link

Wang VE, Schmidt T, Chen J, Sharp PA, Tantin D. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol. 2004 Feb;24(3):1022-32. Pubmed link

Wang VE, Tantin D, Chen J, Sharp PA. B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2005-10. Pubmed link

Cheng C, Sharp PA. RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes. Mol Cell Biol. 2003 Mar;23(6):1961-7. Pubmed link

Doench JG, Petersen CP, Sharp PA. siRNAs can function as miRNAs. Genes Dev. 2003 Feb 15;17(4):438-42. Pubmed link

Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol. 2003 Jun;4(6):457-67. Pubmed link; Article interview link

Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific MicroRNAs. Dev Cell. 2003 Aug;5(2):351-8. Pubmed link


Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002 Sep;3(3):339-50. Pubmed link

Fairbrother WG, Yeh RF, Sharp PA, Burge CB. Predictive identification of exonic splicing enhancers in human genes. Science. 2002 Aug 9;297(5583):1007-13. Pubmed link

Lee KB, Wang D, Lippard SJ, Sharp PA. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4239-44. Pubmed link

McManus MT, Haines BB, Dillon CP, Whitehurst CE, van Parijs L, Chen J, Sharp PA. Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol. 2002 Nov 15;169(10):5754-60. Pubmed link

McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. Gene silencing using micro-RNA designed hairpins. RNA. 2002 Jun;8(6):842-50. Pubmed link

McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet. 2002 Oct;3(10):737-47. Pubmed link

Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nat Med. 2002 Jul;8(7):681-6. Pubmed link

Scarr RB, Sharp PA. PDCD2 is a negative regulator of HCF-1 (C1). Oncogene. 2002 Aug 8;21(34):5245-54. Pubmed link

Tantin D, Sharp PA. Mouse lymphoid cell line selected to have high immunoglobulin promoter activity. Mol Cell Biol. 2002 Mar;22(5):1460-73. Pubmed link

Kim JB, Sharp PA. Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase. J Biol Chem. 2001 Apr 13;276(15):12317-23. Pubmed link

Lim, LP, and Burge, CB. A computational analysis of sequence features involved in recognition of short introns. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11193-8. Pubmed link

Sharp PA. RNA interference--2001. Genes Dev. 2001 Mar 1;15(5):485-90. Pubmed link