Introduction to methods used to elucidate the mechanism
of enzyme-catalyzed reactions. Application of steady-state and presteady-state
kinetics, isotope effect measurements, site-directed mutagenesis, and
mechanism-based inhibitors as tools to investigate the mechanisms of
enzymes that have been well-characterized structurally.
Lectures: TR,
10-11:30AM, Room 1-150
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Academic Honesty
It is expected that students will maintain the highest
standards of academic honesty.
With respect to homework assignments, it is expected
that no student will turn in work that is not his or her own by copying
the work of another student or by using the work or solutions from this
course given in previous years. Discussion of approaches to solving
the homework problems after attempting to work the problems independently,
however, is permitted and encouraged.
It is expected that during a test or examination, a student
will not (1) accept or use information of any kind from other students;
(2) represent the work of another student as his or her own; (3) use
aids to memory other than those expressly permitted by the examiner.
Following a test or examination, a student will not try to deceive teachers
or graders by misrepresenting or altering his or her previous work.
In advance of a test or exam, a student will not knowingly obtain access
to the exam questions.
Departures from the above standards are contrary to fundamental
principles of MIT and of the larger scientific community. Such departures
are considered serious offenses for which disciplinary penalties, including
suspension and expulsion, can be imposed.