9.011

BCS Core I

Fall 2005

Miscellaneous:

Chris Moore: General Anatomy

Textbook chapters:

• Fundamental Neuroscience, chapter 2, chapter 3, and chapter 25 (pp. 667-685).
• Dissection Guide

Discussion articles:

• Gross, CG. (1998). The hippocampus minor and man’s place in nature: a case study in the social construction of neuroanatomy. In: Brain, vision, memory: tales in the history of neuroscience.
• Gibson JR, Beierlein M, and Connors, BW. (1999). Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402: 75-79.

Other materials:

• Lecture 1 Powerpoint
• Lecture 1 Handout
• Lecture 2 Powerpoint
• Lecture 2 Handout
• Lecture 3 Powerpoint
• Lecture 3 Handout

Chris Moore: Somatosensory System

Lecture slides:

• Lecture 1 Powerpoint
• Lecture 1 Handout
• Lecture 2 Powerpoint
• Lecture 2 Handout

Required readings for lecture #1:

• Fundamental Neuroscience, chapter 25.
• Romo et al. (2002) From Sensation to Action. Behavioral Brain Research 135: 105-118. Required pages: 105-114 (top).
• Romo et al. (1998) Somatosensory discrimination based on cortical microstimulation. Nature 392: 387-390. (This is the discussion/summary paper.)

Recommended readings for lecture #1:

• Romo et al. (2002) From Sensation to Action. Behavioral Brain Research 135: 105-118. Entire article.

Required readings for lecture #2:

• Moore et al. (1999) Dynamics of neuronal processing in rat somatosensory cortex. Trends in Neurosciences 22: 513-520.
• van der Loos and Woolsey (1973) Somatosensory Cortex: Structural Alterations following Early Injury to Sense Organs. Science 179(71): 395-8.
• Andermann et al (2004) Neural Correlates of Vibrissa Resonance: Band-Pass and Somatotopic Representation of High-Frequency Stimuli. (This is the discussion/summary paper.)

Recommended readings for lecture #2:

• Neimark et al. (2003) Vibrissa resonance as a transduction mechanism for tactile encoding. Journal of Neuroscience 23: 6499-6509.
• Whiskers!
• Moore et al. (2004) Frequency-Dependent Processing in the Vibrissa Sensory System. Journal of Neurophysiology.

Peter Schiller: Visual System

Outline for lectures:

• Schiller lectures outline.

Textbook chapters:

• Fundamental Neuroscience, chapter 27.
• Online Reading: http://web.mit.edu/bcs/schillerlab/research.html - check outline for which chapters should be read for which class days.

Review articles:

• Waessle H and Boycott BB. (1991) Functional architecture of the mammalian retina. Physiological Rev. 71: 447-479.
• Schiller PH. (1995). The ON and OFF channels of the mammalian visual system. In: Progress in Retinal and Eye Research, Vol 15. (Eds: N.N. Osborne and G.J. Chader), Pergamon Press, Oxford, England.
• Schiller PH and Logothetis NK. (1990) The color-opponent and broad-band channels of the primate visual system. TINS 13: 392-398.
• Schiller PH. (1998) The neural control of visually guided eye movements. In: Cognitive Neuroscience of Attention, Ed: J.E. Richards, Erlbaum Associates.

Recommended reading:

• Sekuler, R. and Blake, R. Perception 1995 (3rd edition) McGraw-Hill. Chapter 5, Chapter 6, Chapter 7, and Chapter 8. This is for students with no background in vision.
• Schiller PH. (1986). The central visual system. Vision Res. 26: 1351-1386.
• Schiller PH. (1997). Past and present ideas about how the visual scene is analyzed by the brain. Cerebral Cortex, Vol 12: Extrastriate Cortex, eds. Kaas and Rockland, Plenum Press.
• Tehovnik JE, Sommer MA, Chou I, Slocum WM, and Schiller PH. (2000). Eye fields in the frontal lobes of primates. Brain Research Reviews 32: 413-448.

Discussion articles:

• Maunsell JHR, Nealy TA and DePriest DD. (1990). Magnocellular and parovcellular contributions to responses in the middle temporal area (MT) of the macaque monkey. J. Neurosci. 10: 3323-3334.
• Ferrera VP, Nealy TA and Maunsell JHR. (1992). Mixed parvocellular and magnocellular geniculate signals in visual area V4. Nature 358: 756-758.
• Slocum, W.M. and Tehovnik, E.J. (2004) Microstimulation of V1 input layers disrupts the selection and detection of visual targets by monkeys. European Journal of Neuroscience, 20, 1674-1680.
• Hikosaka O and Wurtz RH. (1985). Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculine in monkey superior colliculus. J. Neurophysiol. 53: 266-291.
• Oyster CW and Barlow HB. (1967). Direction-selective units in rabbit retina: distribution of preferred directions. Science 155: 841-842.

Lecture slides:

• Lecture 1 PDFs (1, 2)
• Lecture 2 PDFs (1, 2)
• Lecture 3 PDFs (1, 2)
• Lecture 4 PDFs (1)
• Lecture 5 PDFs (1, Final Summary)

Textbook chapters:

• Fundamental Neuroscience, chapter 26.

Review articles:

• Brown MC. (2001). Functional neuroanatomy of the cochlea. In A. F. Jahn & J. Santos-Sacchi (Eds.), Physiology of the Ear (pp. 529-548). New York: Raven Press.
• Hudspeth AJ. (2000). Hearing. In E. R. Kandel, J. H. Schwartz, & T. M. Jessell (Eds.), Principles of Neural Science 4th Ed. (Chapter 30, pp. 590-613). New York: McGraw-Hill.
• Hudspeth AJ. (2000). Sensory Transduction in the Ear. In E. R. Kandel, J. H. Schwartz, & T. M. Jessell (Eds.), Principles of Neural Science 4th Ed. (Chapter 31, pp. 614-624). New York: McGraw-Hill.

Discussion articles:

• Liberman MC, Gao J, He DZZ, Wu X, Jia S, and Zuo J. (2002). Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 419: 300-304.
• Brand A, Behrend O, Marquardt T, McAlpine D, and Grothe B. (2002). Precise inhibition is essential for microsecond interaural time difference coding. Nature 417: 543-547.
• Zatorre RJ and Penhune VB (2001) Spatial localization after excision of human auditory cortex. J. Neurosci. 21: 6321-6328.
• May BJ, Prosen CA, Weiss D and Vetter D. (2002). Behavioral investigation of some possible effects of central olivocochlear pathways in transgenic mice. Hearing Res. 171: 142-157.

Michale Fee : Motor System

Textbook chapters:

• Fundamental Neuroscience, chapter 28, 29, 30, 31, 32.

Review articles:

• Rizzolatti G and Luppino G. (2001). The cortical motor system. Neuron 31: 889-901.
• Scott SH (2003). The role of primary motor cortex in goal-directed movements: insights from neurophysiological studies on non-human primates. Curr Opin Neurobiol 1#:671-677.
• Hikosaka et al. (1999). Parallel neural networks for learning sequential procedures. TINS 22: 464-471.
• Graybiel AM and Saka E (2004). The basal ganglia and the control of action. In: The New Cognitive Neurosciences, 3rd Ed., MS Gazzaniga, Ed. Cambridge, MA: MIT Press. In Press. (PDF coming soon)
• Schultz W (2004). Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioral ecology. Curr Opin Neurobiol 14: 139-147.
• Thach WT, Goodkin HP, and Keating JT. (1992). The cerebellum and the adaptive coordination of movement. Annu. Rev. Neurosci. 15: 403-442.
• Fetz EE et al. Roles of primate spinal interneurons in preparation and execution of voluntary hand movement. Brain Res Rev 40: 53-56.
• Nicolelis, MA (2003). Brain-machine interfaces to restore motor function and prob neural circuits. Nat Rev Neurosci 4: 417-422.

Discussion articles:

• Graziano MSA, Taylor CSR, and Moore T. (2002). Complex movements evoked by microstimulation of precentral cortex. Neuron 34: 841-851.
• And commentary on the Graziano article: Krauzlis RJ. (2002). Reaching for answers. Neuron 34: 673-674.
• Carmena JM, et al (2003). Learning to control a brain-machine interface for reaching and grasping by primates. PLoS Biology 1:1-16.
• Shima K and Tanji J (2000). Neuronal Activity in the Supplementary and Presupplementary Motor Areas for Temporal Organization of Multiple Movements. J Neurophys.
• Fiorillo et al. (2003) Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons. Science 299: 1898 -1902.

Lecture slides:

• Lecture Slides

Matthew Wilson: Memory

Textbook chapters:

• Fundamental Neuroscience, chapters 50-51.

Review articles:

• Moser EI and Paulsen O. (2001). New excitement in cognitive space: between place cells and spatial memory. Current Opinion in Neurobiology 11: 745-751.

Discussion articles:

• Nakazawa K, Sun LD, Quirk MC, Rondi-Reig L, Wilson MA, Tonegawa S. (2003). Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron 38: 305-15.
• Brun VH, Otnass MK, Molden S, Steffenach HA, Witter MP, Moser MB, Moser EI. (2002). Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry. Science 296: 2243-6.
• Frank LM, Brown EN, Wilson M. Trajectory encoding in the hippocampus and entorhinal cortex. (2000). Neuron 27: 169-78.

Susumu Tonegawa: Genetics and Memory.

Textbook chapters:

• Squire L. and Kandel E. Chapter 6 in "Memory. From Mind to Molecules."

Review articles:

• Wilson MA and Tonegawa S. (1997). Synaptic plasticity, place cells and spatial memory: study with second generation knockouts. TINS 20: 102-106.
• Griffiths D, Dickinson A, and Clayton N. (1999). Episodic memory: what can animals remember about their past? TICS 3: 74-80.
• Anagnostaras SD, Maren S, and Fanselow MS. (1999). Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination. J. Neurosci. 19: 1106-14.

Discussion articles:

• Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Johnston D, Wilson MA, and Tonegawa S. (2002). Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297: 211-218.
• Kida S, Josslyn SA, deOrtiz, SP, Kogan JH, Chevere I, Masushige S, and Silva AJ. (2002). CREB required for the stability of new and reactivated fear memories. Nat. Neurosci. 5: 348-55.
• Tang et al. (1999). Genetic enhancement of learning and memory in mice. Nature 401: 63-69.

Other materials:

• Lecture Slides 1 & 2
• Lecture Slides 3

Earl Miller: Attention and Executive Control

Textbook chapters:

• Fundamental Neuroscience, chapters 48-49, 53 and 54.

Review articles:

• Miller EK and Cohen JD. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience 24: 167-202.
• Fuster JM. (2000). Executive frontal functions. Exp Brain Res. 133: 66-70.

Discussion articles:

• Tomita H, Ohbayashi M, Nakahara K, Hasegawa I, Miyashita Y. (1999). Top-down signal from prefrontal cortex in executive control of memory retrieval. Nature 401: 699-703.
• Wallis JD, Anderson KC, and Miller EK. (2001). Single neurons in the prefrontal cortex encode abstract rules. Nature 411: 953-956.
• Everling S, Tinsley CJ, Gaffan D, Duncan J. (2002) Filtering of neural signals by focused attention in the monkey prefrontal cortex. Nat Neurosci. 5: 671-6.

Lecture slides:

• Lecture Slides
• Lectures 1&2 (2004)
• Lectures 3&4 (2004)