Paul F. Glenn Center for the Science of Aging Research at MIT


  1. Guarente, L., Mitchell, D., and Beckwith, J. (1977). Transcription termination at the end of the tryptophan operon of E. coli. J. Mol. Biol. 112: 423-436.
  2. Guarente, L., and Beckwith, J. (1978). A mutant RNA polymerase of E. coli which terminates transcription in strains making defective rho factor. Proc. Natl. Acad. Sci. USA 75: 294-297.
  3. Bassford, P., Beckwith, J., Berman, M., Brickman, E., Casadaban, M., Guarente, L.,Saint-Girons, I., Sarthy, A., Schwartz, N., Shuman, H., and Silhavy, T. (1978). Genetic fusions of the lac operon: a new approach to the study of biological processes. In: The Operon (J.H. Miller and W.S. Reznikoff, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
  4. Guarente, L. (1979). Restoration of termination by RNA polymerase mutations is rho allele specific. J. Mol. Biol. 129: 295-304.
  5. Silhavy, T., Brickman, E., Bassford, P., Casadaban, M., Shuman, A., Schwartz, V., Guarente, L., Schwartz, M., and Beckwith, J. (1979). Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE, F, G operon. Mol. Gen. Genet. 174: 249-259.
  6. Guarente, L., Beckwith, J., Wu, A., and Platt, T. (1979). A_mutation distal to the messenger RNA endpoint reduced transcription termination in the tryptophan operon in Escherichia coli. J. Mol. Biol. 133: 189-197.
  7. Wu, A., Chapman, A., Platt, T., Guarente, L., and Beckwith, J. (1980). Deletions of distal sequences affect termination of transcription at the end of the tryptophan operon in Escherichia coli. Cell 19: 829-836.
  8. Guarente, L., Lauer, G., Roberts, T. M., and Ptashne, M., (1980). Improved methods for maximizing expression of a cloned gene: a bacterium that synthesized rabbit beta-globin. Cell 20: 543-553.
  9. Guarente, L., Isberg, R., Syvanen, M. and Silhavy, T. (1980). The conferral of transposable properties to a chromosomal gene in Escherichia coli. J. Mol. Biol. 141: 235-248.
  10. Taniguchi, T., Guarente, L., Roberts, T. M., Kimelman, D., Douhan III, J., and Ptashne, M. (1980). Expression of the human fibroblast interferon gene in Escherichia coli. Proc. Natl. Acad. Sci. USA 77: 5230-5233.
  11. Guarente, L., Roberts, T. M., and Ptashne, M. (1980). A technique for expressing eukaryotic genes in bacteria. Science 209: 1428-1430.
  12. Guarente, L., and Ptashne, M. (1981). Fusions of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 78: 2199-2203.
  13. Guarente, L., Nye, J.,Hoschild, A., and Ptashne, M. (1982). A mutant repressor of phage lambda with a specific defect in its positive control function. Proc. Natl. Acad. Sci. USA 79: 2199-2203.
  14. Gray, M., Colot, H., Guarente, L., and Rosbash, M. (1982). ORF cloning: the identification, cloning, and expression of open reading frame DNA. Proc. Natl. Acad. Sci. USA 79: 6598-6602.
  15. Guarente, L., Yocum, R., and Gifford, P. (1982). A GAL10-CYC1 hybrid promoter identifies the GAL4 regulatory region as an upstream site. Proc. Natl. Acad. Sci. USA 79: 7410-7414.
  16. Guarente, L. (1983). Yeast promoter and lacZ fusions designed to study expression of cloned genes in yeast. Meth. Enz. 101: 181-191.
  17. Guarente, L., and Mason, T. (1983). Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell 32: 1279-1286.
  18. Michaelis, S., Guarente, L., Inouye, H., and Beckwith, J. (1983). In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli. J. Bacteriol. 154: 356-365.
  19. Guarente, L. (1983). Transcription of the yeast CYC1 gene is activated by heme via an upstream activation site. In: Enhancers and Eukaryotic Gene Expression (Y. Gluzman and T. Shent, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. pp. 190-193.
  20. Mason, T., Little, H. N., Van Sickle, C., and Guarente, L. (1984). The role of heme and oxygen in the regulation of mitochondrial cytochromes. In: Nucleo-cytoplasmic Interactions (Wolf, Schweyen, and Kandewitz, eds.) de Gruyter.
  21. Guarente, L. (1984). Use of gene fusions to study biological problems. In: Genetic Engineering, Principles and Methods, Vol. 6 (J. K. Setlow and A. Hollaender, eds.) Plenum Press, New York. pp. 233-251.
  22. Guarente, L., Lalonde, B., Gifford, P., and Alani, E. (1984). Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of Saccharomyces cerevisiae. Cell 36: 503-511.
  23. Guarente, L. (1984). Yeast promoters: Positive and negative elements. Cell 36: 799-800.
  24. Guarente, L., and Hoar, E. (1984). The upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the TATA box. Proc. Natl. Acad. Sci. USA 81: 7860-7864.
  25. Guarente, L. (1984). Regulation of cytochrome-encoding genes in Saccharomyces cerevisiae. In: Proceedings of the Developmental Society Symposium (June, 1984).
  26. Guarente, L. (1985). Yeast UASs as coordinators of gene expression. In: Eukaryotic Transcription. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  27. Guarente, L. (1985). Regulation of the yeast CYC1 gene. In: Microbiology. American Society for Microbiology, pp. 37383.
  28. Pinkham, J., and Guarente, L. (1985). Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 5: 3410-3416.
  29. Hahn, S., Hoar, E., and Guarente, L. (1985). Each of three "TATA elements" specifies a subset of the initiation sites of the CYC1 promoter of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 82: 8562-8566.
  30. Keng, T., Alani, E., and Guarente, L. (1986). Amino-terminal fragment of delta-aminolevulinate synthase can direct beta-galactosidase to the mitochondrial matrix. Mol. Cell. Biol. 6: 355-364.
  31. Kim, K. S., Rosenkranz, M., and Guarente, L. (1986). Saccharomyces cerevisiae contains two functional citrate synthase genes. Mol. Cell. Biol. 6: 1936-1942.
  32. Verdiere, J., Creusot, F., Guarente, L., and Slonimski, P. P. (1986). The overproducing CYP1 and the underproducing HAP1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes. C. Current Genetics 10: 339-342.
  33. Wei, R., Wilkinson, H., Pfeifer, K., Schneider, C. J., Young, R., and Guarente, L. (1986). Two or more copies of Drosophila heat shock consensus serve to activate transcription in yeast. Nucl. Acids Res. 14: 8183-8188.
  34. Rosenkrantz, M., Tausif, A., Kim, K. S., Clark, B., Srere, P., and Guarente, L. (1986). Mitochondrial and non-mitochondrial citrate synthases in yeast are encoded by distinct homologous genes. Mol. Cell. Biol. 6: 4509-4515.
  35. Guarente, L. (1986). Regulation of the yeast CYC1 gene. In: Extrachromosomal Elements in Lower Eukaryotes (Wickner, R.B., A. Hinnebusch, A.M. Lambowitz, I.C. Gunsalus and A. Hallaender, eds.). Plenum Press, New York, Basic Life Sciences, 40: 513-518.
  36. Guarente, L. (1986). Recent progress in studies of CYC1 transcriptional regulation. In: Biological Research on Industrial Yeasts Vol. III. CRC Press, Inc., Florida.
  37. Lalonde, B., Arcangioli, B., and Guarente, L. (1986). A single upstream activation site, UAS1, has two distinct regions essential for its activity. Mol. Cell. Biol. 6: 4690-4696.
  38. Pinkham, J., Olesen, J., and Guarente, L. (1987). Sequence and nuclear localization of the yeast HAP2 protein, an activator of transcription. Mol. Cell. Biol. 7: 578-585.
  39. Pfeifer, K., Arcangioli, B., and Guarente, L. (1987a). Yeast HAP1 activation competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene. Cell 49: 9-18.
  40. Pfeifer, K., Prezant, T., and Guarente, L. (1987b). Yeast HAP1 activator binds to two upstream activation sites of different sequences. Cell 49: 19-27.
  41. Schneider, J., and Guarente, L. (1987). The unstranslated leader of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron. Nuc. Acids Res. 15: 3515-3529.
  42. Greene, J., and Guarente, L. (1987). Subcloning. In: Methods in Enzymology, 152, pp.512-521.
  43. Prezant, T., Pfeifer, K., and Guarente, L. (1987). Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation. Mol. Cell. Biol. 7: 3252-3259.
  44. Guarente, L. (1987). Regulatory proteins in yeast. Ann. Rev. Gen. 21: 425-452.
  45. Keng, T., and Guarente, L. (1987). Multiple regulatory systems result in constitutive expression of the yeast HEM1 gene. Proc. Natl. Acad. Sci. USA 84: 9113-9117.
  46. Hahn, S., Pinkham, J., Wei, R., Miller, R., and Guarente, L. (1988). Isolation and characterization of the HAP3 gene of Saccharomyces cerevisiae: A second regulatory gene required for activity of the CYC1 UAS2 element. Mol. Cell. Biol. 8: 655-663.
  47. Olesen, J., Hahn, S., and Guarente, L. (1987). Yeast HAP2 and hap3 activators both bind to the CYC1 activation site, UAS2, in an interdependent manner. Cell 51: 953-961.
  48. Forsburg, S., and Guarente, L. (1988). Mutational analysis of the upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site. Mol. Cell. Biol. 8: 647-654.
  49. Hahn, S., and Guarente, L. (1988). Yeast HAP2 and HAP3: Transcription activators in a heteromeric complex. Science 240: 317-321.
  50. Chodosh, L., Olesen, J., Hahn, S., Baldwin, A., Guarente, L., and Sharp, P. (1988). A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53: 25-35.
  51. Guarente, L. (1988). UASs and Enhancers: Common mechanism of transcriptional activation in yeast and mammals. Cell 52: 303-305.
  52. Osborne, B., and Guarente, L. (1988). Transcription by RNA polymerase II induces changes of DNA topology in yeast. Genes and Development 2: 766-772.
  53. Kispal, G., Rosenkrantz, M., Guarente, L., and Srere, P. (1988). Metabolic changes in Saccharomyces cerevisiae strains lacking citrate synthase. J. Biol. Chem. 263: 11145-11149.
  54. Buratowski, S., Hahn, S., Sharp, P., and Guarente, L. (1988). Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature 334: 37-42.
  55. Zagorec, M., Bahler, J., Treich, I., Keng,T., Guarente, L., and Labbe-bois, R. (1988). Isolation, sequence and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. J. Biol. Chem. 263: 9718-9724.
  56. Pfeifer, K., Kim, K. S., Kogan, S., and Guarente, L. (1989). Functional dissection and sequence of yeast transcriptional activator HAP1. Cell 56: 291-301.
  57. Osborne, B., and Guarente, L. (1989). Mutational analysis of a yeast transcriptional terminator. Proc. Natl. Acad. USA, 86: 4097-4101.
  58. Buratowski, S., Hahn, S., Guarente, L., and Sharp, P. (1989). Five intermediate complexes in transcription initiation by RNA polymerase II. Cell 56: 549-561.
  59. Elledge, S. J., Sugiono, P., Guarente, L., and Davis, R. W. (1989). A genetic selection for genes encoding sequence-specific DNA-binding proteins. Proc. Natl. Acad. Sci. USA 86: 3689-3693.
  60. Forsburg, S. L., and Guarente, L. (1989a). Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. Ann. Rev. Cell Biol. 5: l53-180.
  61. Forsburg, S., and Guarente, L. (1989b). Identification and characterization of HAP4, a third component in the CCAAT-bound HAP2/3 heteromer. Genes and Devel. 3: 1166-1178.
  62. Hahn, S., Buratowski, S., Sharp, P., and Guarente, L. (1989). Yeast TATA binding protein TF II D binds to TATA elements with both consensus and nonconsensus DNA sequences. Proc. Natl. Acad. Sci. USA 86: 5718-5722.
  63. Hahn, S., Buratowski, S., Sharp, P., and Guarente, L. (1989). Identification of a yeast protein homologous in function to the mammalian general transcription factor TF II A. EMBO J. 8: 3379-3382.
  64. Kim, K. S., and Guarente, L. (1989). Mutations in the zinc finger DNA binding domain of a yeast activator alter activation of the transcriptional machinery. Nature 342: 200-203.
  65. Hahn, S., Buratowski, S., Sharp, P., and Guarente, L. (1989) Isolation of the gene encoding the yeast TATA-binding protein TFIID: a gene identical to the SPT15 Suppressor of TY element insertions. Cell 58: 1173-1181.
  66. Haldi, M., and Guarente, L. (1989). N-terminal deletions of a mitochondrial signal sequence in yeast. Targeting information of d-aminolevulinate synthase is encoded in non-overlapping regions. J. Biol. Chem. 264: 17107-17112.
  67. Kim, K. S., Pfeifer, K., Powell, L., and Guarente, L. (1990). Internal deletions in the yeast activator HAP1 have opposite effects at two sequence elements. Proc. Natl. Acad. Sci. USA 87: 4524-4528.
  68. Olesen, J.T., and Guarente, L. (1990). The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: Model for the HAP2/3/4 complex. Genes and Devel. 4: 1714-1729.
  69. Fikes, J.D., Becker, D.M., Winston, F., and Guarente, L. (1990). Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Nature 346: 291-294.
  70. Berger, S.L., Cress, W.D., Cress, A., Treizenberg, S.J., and Guarente, L. (1990). Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors. Cell 61: 1199-1208.
  71. Schneider, J.C., and Guarente, L. (1991). Vectors for expression of cloned genes in yeast: regulation, overproduction and underproduction. Meth. Enz. 194: 373-388.
  72. Schneider, J.C., and Guarente, L. (1991). Regulation of the yeast CYT1 gene encoding Cytochrome C1 by HAP1 and HAP2/3/4. Mol. Cell. Biol. 11: 4934-4942.
  73. Becker, D.M., and Guarente, L. (1991). High-efficiency transformation of yeast by electroporation. Meth. Enz. 194: 182-187.
  74. Becker, D.M., Fikes, J.D., and Guarente, L. (1991). A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. Proc. Natl. Acad. Sci. USA 88: 1968-1972.
  75. Olesen, J., Fikes, J., and Guarente, L. (1991). The fission yeast homolog of budding yeast HAP2 reveals selective and stringent conservation of the small "essential core" protein domain. Mol. Cell. Biol. 11: 611-619.
  76. Guarente, L. Messenger RNA transcription and its control in Saccharomyces cerevisiae (1992). In: The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression (Jones, Pringle and Broach, eds.). Cold Spring Harbor Press, New York.
  77. Guarente, L. Mechanism and regulation of transcriptional activation in eukaryotes: Conserved features from yeasts to humans (1992). In: Transcriptional Regulation (McKnight and Yamamoto, eds.). Cold Spring Harbor Press, New York.
  78. Guarente, L., and Bermingham-McDonogh, O. (1992). Conservation and evolution of transcriptional mechanisms in eukaryotes. Trends in Genetics 8: 27-32.
  79. Eide, D., and Guarente, L. (1992). Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. J. Gen. Microbiol. 138: 347-354.
  80. Berger, S.L., Pina, B., Silverman, N., Marcus, G.A., Agapite, J., Regier, J.L., Triezenberg, S.J., and Guarente, L. (1992). Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains. Cell 70: 251-265.
  81. Turcotte, B., and Guarente, L. (1992). HAP1 positive control mutants specific for one of two binding sites. Genes and Devel. 6: 2001-2009.
  82. Zhang, L., Bermingham-McDonogh, O., Turcotte, B., and Guarente, L. (1993). Antibody-promoted dimerization bypasses the regulation of DNA-binding by the heme domain of yeast transcriptional activator HAP1. Proc. Natl. Acad. Sci. USA 90: 2851-2855.
  83. Guarente, L. (1993). Commentary: Strategies for the identification of interacting proteins. Proc. Natl. Acad. Sci. USA 90: 1639-1641.
  84. Guarente, L. (1993). Synthetic enhancement in gene interaction: A genetic tool come of age. Trends in Genetics 9: 362-366.
  85. Pina, B., Berger, S., Marcus, G.A., Silverman, N., Agapite, J., and Guarente, L. (1993). ADA3: A gene identified by resistance to GAL4-VP16 with properties similar to and different from ADA2. Mol. Cell. Biol. 13: 5981-5989.
  86. Xing, Y., Fikes, J.D., and Guarente, L. (1993). Mutations in yeast HAP2-HAP3 define a hybrid CCAAT box-binding domain. EMBO J. 12: 4647-4655.
  87. Zhang, L., and Guarente, L. (1994). Evidence that TUP1/SSN6 has a positive role on the activity of the yeast activator HAP1. Genetics 136: 813-817.
  88. Zhang, L., and Guarente, L. (1994). HAP1 is nuclear but is bound to a cellular factor in the absence of heme. J. Biol. Chem. 269: 14643-14647.
  89. Xing, Y., Zhang, S., Olesen, J.T., Rich, A., and Guarente, L. (1994). Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short a-helix in HAP2. Proc. Natl. Acad. Sci. USA 91: 3009-3013.
  90. Zhang, L., and Guarente, L. (1994). The yeast activator HAP1 - a GAL4 family member - binds DNA in a directly repeated orientation. Genes and Devel., 8: 2110-2119.
  91. Marcus, G.A., Silverman, N., Berger, S.L., Horiuchi, J., and Guarente, L. (1994). Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. EMBO J., 13: 4807-4815.
  92. Silverman, N., Agapite, J., and Guarente, L. (1994). Yeast ADA2 binds to the VP16 activation domain and activates transcription. Proc. Natl. Acad. Sci USA , 91, 11665-11668.
  93. Kennedy, B.K., Austriaco, N.R., Jr., and Guarente, L. (1994). Daughter cells of S. cerevisiae from old mothers display a reduced life span. J. Cell Biol., 137 1985-1993.
  94. Zhang, L., and Guarente, L. (1995). A short protein motif binds heme and modulates the activity of a transcriptional activator HAP1. EMBO J., 14, 313-320.
  95. Horiuchi, J., Silverman, N., Marcus, G.A., and Guarente, L. (1995). ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex. Mol. Cell. Biol., 15, 1203-1209.
  96. Kennedy, B., Austriaco, N., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in Saccharomyces cerevisiae. Cell, 80, 485-496.
  97. McNabb, D., Xing, Y., and Guarente, L. (1995). Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT-binding. Genes & Devel., 9, 47-58.
  98. Berger, S.L., Turcotte, B., and Guarente, L. (1995). The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different cofactor requirements. Genes, 158, 163-173.
  99. Haldi, M., and Guarente, L. (1995). Heme is required for both the DNA-binding and transcriptional activation functions of the yeast activator HAP1. Mol. Gen. Genet., 248, 229-235.
  100. Guarente, L. (1995). Transcriptional coactivators in yeast and beyond. TIBS 12, 517-521.
  101. Knaus, R., Pollock, R., and Guarente, L. (1996). Yeast SUB1: A Suppressor of a TFIIB mutation with homology to the human coactivator PC4. EMBO J. 8, 1933-1940.
  102. Smeal, T., Claus, J., Kennedy, B.K., Cole, F., and Guarente, L. (1996). Loss of Transcriptional Silencing in Old Mother Cells of Saccharymoces Cerevisiae. Cell, 84, 633-642.
  103. Zhang, L., and Guarente, L. (1996). The Determinant of Asymetric Binding by HAP1 -- The C6 Zinc Cluster. EMBO J., 15, 4676-4681.
  104. Marcus, G.A., Silverman, N., and Guarente, L. (1996). Cloning and Characterization of ADA5/SPT20: A Gene with Properties of Two Transcriptional Superfamilies. Mol. Cell Biol. 6, 3197-3205.
  105. Kennedy, B., and Guarente, L. (1996). Genetic Analysis of Aging in Saccharomyces cerevisiae. Trends in Genetics 12, 355-359.
  106. Lombard, D., and Guarente, L. (1996). Cloning the gene for Werner's syndrome, a disease with many symptoms of premature aging. Trends in Genetics 12, 283-286.
  107. Guarente, L. (1996). Do changes in chromosomes cause aging? Cell, 86, 9-12.
  108. McNabb, D., and Guarente, L. (1996). Genetic and biochemical probes for protein-protein interaction. Current Opinion in Biotechnology 7, 554-559.
  109. Smeal, T., and Guarente, L. (1997). Mechanisms of cellular senescence. Current Opinion in Genetics and Development 7, 281-287.
  110. Kennedy, B., Gotta, M., Sinclair, D., Mills, K., McNabb, D., Marthy, M., Pak, S., Laroche, T., Gasser, S., and Guarente, L. (1997). Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89, 381-392.
  111. Guarente, L. (1997). What makes us tick? Science 275, 943-944.
  112. Silverman, N., and Guarente, L. (1997). Of acetylation, activation, and toxicity, the role of the ADA/GCN5 complex in trancription. Nucleic Acids and Molecular Biology 11, 305-319.
  113. Horiuchi, J., Silverman, N., Pina, B, Marcus, G., and Guarente, L. (1997). ADA1, a novel component of the ADA/GCN5 complex has broader effects of GCN5, ADA2, ADA3. Mol. Cell. Biol. 17, 3220-3228.
  114. McNabb, D., Pak, S., and Guarente, L. (1997). Construction of a hisG-ura4+-hisG cassette for sequential gene disruptions in the yeast Schizosaccharomyces pombe. BioTechiques 22, 1134-1139.
  115. Austriaco, N., and Guarente, L. (1997). Inverse correlation between telomere length and lifer span in Saccharomyces cerevisiae. Proc. Nat. Acad. Sci. 94, 9768-9772.
  116. Sinclair, D., Mills, K., and Guarente, L. (1997). Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants. Science, 277, 1313-1316.
  117. Guarente, L. (1997). Link between aging and the nucleolus. Genes and Devel. 11, 2449-2555.
  118. Sinclair, D., and Guarente, L. (1997). Extrachromosomal rDNA circles - a cause of yeast aging. Cell 91, 1033-1042.
  119. McNabb, D., Tseng, K., and Guarente, L. (1997). The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor. Mol. Cell. Biol. 17, 7008-7018.
  120. Sinclair, D., Mills, K., and Guarente, L. (1998). Molecular mechanisms of yeast aging. TIBS 23, 131-134.
  121. Marciniak, R.A., Lombard, D., Johnson, F. Bradley, and Guarente, L. (1998). Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. 95, 6887-6992.
  122. Johnson, F. B., Marciniak, R. M., and Guarente, L. (1998). Telomeres, the nucleolus, and aging. Current Opinion in Cell Biology 10, 332-338.
  123. Guarente, L., Ruvkun, G., and Amasino, R. (1998). Aging, life span, and senescence. Proc. Natl. Acad. Sci. 95, 11034-11036.
  124. Defossez, P.A., Park, P. U., and Guarente, L. (1998). Vicious circles: a mechanism for yeast aging. Current Opinion in Microbiology, 1, 707-711.
  125. Johnson, F. B., Sinclair, D., and Guarente, L. (1999). Molecular biology of aging. Cell 96, 291-302.
  126. Park, P.U., Defossez, P.A., and Guarente, L. (1999). Effects of Mutations in DNA Repair Genes on the Formation of rDNA Circles and Life-span in S. cerevisiae. Mol. Cell. Biol., 19: 3848-3856.
  127. Defossez, P.A., Prusty, R., Kaeberlein, M., Lin, S., Ferrigno, P., Silver, P., Keil, R., and Guarente, L. (1999). Elimination of Yeast Replication Block Protein Fob1p Extends the Life Span of Mother Cells. Molecular Cell, 3, 447-455.
  128. Mills, K.D., Sinclair, D.A., and Guarente, L. (1999). MEC1 -dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell, 97, 609-620.
  129. King, D.A., Zhang, L., Guarente, L., and Marmorstein, R. (1999). Structure of a HAP1-DNA Complex Reveals Dramatically Asymmetric DNA binding by a Homodimeric Protein. Nature Structural Biol., 6, 64-71.
  130. King, D.A., Zhang, L., Guarente, L., and Marmorstein, R. (1999). Structure of a HAP1-18-DNA Implicates Direct Allosteric Effect of Protein-DNA Interactions on Transcriptional Activation. Nature Structural Biol., 6, 22-27.
  131. Ashrafi, K., Sinclair, D., Gordon, J., and Guarente, L. (1999). Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 96, 9100-9105.
  132. Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in S. cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2581.
  133. Guarente, L. (1999). Diverse and dynamic new functions of the Sir silencing complex. Nat. Genet. 23, 281-286.
  134. Guarente, L. (1999). Extending mammalian life span. Nature 402, 243-245.
  135. Imai, S., Armstrong, C., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature, 403, 795-800.
  136. Lombard, D. B., Beard, C., Dausman, J., Bronson, R., Lipman, R., Buhlman, J., Curry, R., Sharpe, A., Johnson, F. B., Marciniak,, R., Jaenisch, R., and Guarente, L. (2000). Mutations in the WRN gene in mice accelerate mortality in a p53 null background. Mol. Cell. Biol. 20, 3286-3291.
  137. Tissenbaum, H., Hawson, J., Perregaux, M., Hotez, P., Guarente, L., and Ruvkun, G. (2000). A common Muscarinic pathway in the distantly related nematode species C. elegans and Ancylostoma canium. Proc. Nat. Acad. Sci. 97, 460-465.
  138. Johnson, F. B., Lombard, D., Neff, N., Mastrangelo, A., Dewolf, W., Ellis, N., Marciniak, R., Yin, Y., Jaenisch, R., and Guarente, L. (2000). Association of the Bloom syndrome protein with topoisomerase IIIa in somatic and meiotic cells. Cancer Res. 60, 1162-1167.
  139. Marciniak, R. A., Johnson, F. B., and Guarente, L. (2000). Dyskeratosis Congenita, telomeres, and aging. Trends Gen. 16, 193-195.
  140. Lombard, D. B., and Guarente, L. (2000). Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60, 2331-2334.
  141. Guarente, L. (2000). Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 14, 1021-1026.
  142. Yankiwski, v., Marciniak, R. A., Guarente, L., and Neff, N. (2000) Nuclear structure in normal and Bloom syndrome cells. Proc. Nat. Acad. Sci. 97, 5214-5219.
  143. Imai, S., Johnson, F. B., Marciniak, R., McVey, M., Park, P., and Guarente, L. (2000). Sir2: An NAD- dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. Cold Spring Harbor Symp. Quant. Biol. in press
  144. Lin, S. J., Defossez, P.-A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in S. cerevisiae. Science, 289, 2126-2128.
  145. Guarente, L. and Kenyon, C. (2000). Genetic pathways that regulate aging in model organisms. Nature, 408, 255-262.
  146. Johnson, F. B., Marciniak, R., McVey, M., Stewert, S., Hahn, W., and Guarente, L. (2001). The S. cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 20, 905-913.
  147. Tissenbaum, H., and Guarente, L., (2001). Increased dosage of a C. elegans sir-2 gene extends life span in C. elegans. Nature, 410, 227-230.
  148. McVey, M., Kaeberlein, M., Tissenbaum, H., and Guarente, L. (2001). The short life span of S. cerevisiae sgs1 and srs1 mutants is a composite of normal aging processes and a Rad9-dependent cell cycle arrest. Genetics, 157, 1531-1542.
  149. Guarente, L. (2001). SIR2 and aging—the exception that proves the rule. Trends Gen. 17, 393-393.
  150. Hu, P., Beresten, S., van Brabant, A., Ye, T.-Z., Pandolphi, P., Johnson, F. B., Guarente, L., and Ellis, N. (2001). Evidence for BLM and topoisomerase IIIa interaction in genomic stability. Hum. Mol. Gen. 10, 1287-1298.
  151. Park, P. U., McVey, M., and Guarente, L. (2001). Separation of mother and daughter cells. Meth. Enz. In press.
  152. Marciniak, R., and Guarente, L. (2001) Testing telomerase. Nature, 413, 370-373.
  153. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Shiloh, A., Guarente, L., and Gu, W. (2001). Negative control of p53 by Sir2a promotes cell survival under stress. Cell 107, 137-148.
  154. Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S.-I., Frye, R. A., Pandita, T. K., Guarente, L., and Weinberg, R. A. (2001). hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159.
  155. Tissenbaum, H., and Guarente, L. (2002) Model organisms as a guide to mammalian aging. Dev. Cell, 2, 9-19.
  156. 156. Kaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics, 160, 83-95.
  157. Armstrong, C., and Guarente, L. (2002). Mutations in the S. cerevisiae SIR2 gene can have differential effects on silencing in vivo and histone deacetylation in vitro. Mol. Biol. Cell. 13, 1427-1438.
  158. Lin, S. J. Kaeberlein, M., Andalis, A., Sturtz, L. A., Defossez, P., Culotta, V. C., Fink, G. R. and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature, 418, 344-348.
  159. Kaeberlein, M., Andalis, A., Fink, G., and Guarente, L. (2002). High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell Biol. 22, 8056-8066.
  160. Kubova, J., and Guarente, L. (2003). How does calorie restrriction work? Genes and Dev. 17, 313- 321.
  161. Lin, S. J. and Guarente, L. (2003). Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity, and disease. Current Opinion in Cell Biology 15, 241-246.
  162. Hekimi, S. and Guarente, L. (2003) Genetics and the specificity of the aging process. Science, 299, 1351-1354.
  163. Guarente, L. (2003). Ageless quest. Cold Spring Harbor Press, New York.
  164. Blander G, de Oliveira RM, Conboy CM, Haigis M, Guarente L. (2003). Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J. Biol. Chem. 278, 38966-9.
  165. Lin, S. J., Ford, E., Haigis, M., Liszt, G., and Guarente, L. (2004). Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 18, 12-16.
  166. Picard, F., Kurtev, M., Chung, N., Topark-Ngarmm, A., Senawong, T, Machado de Oliveira, R., Leid, M, McBurney, M. and Guarente, L. (2004). SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-g. Nature, 429, 771-776. published online June 2.
  167. Motta, M. C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M., and Guarente, L. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563.
  168. Kaeberlein, M., Andalis, A., Liszt, G., Fink, G., and Guarente, L. (2004). Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics, 166, 1661-1672.
  169. Blander, G. and Guarente, L. (2004). The SIR2 family of protein deacetylases. Ann Rev. Biochem. 73, 417-436.
  170. Du, X., Shen, J., Kugan, N., Furth, E., Lonbard, D., Cheung, C., Pak, S., Luo, G., Pignolo, R., DePinho, R., Guarente, L., and Johnson, B. (2004). Telomere shortening exposes functions for the mouse Werner and Bloon syndrome genes. Mol. Cell Bio., 24, 8437-8446.
  171. Chang, S., Mulani, A., Cabera, N., Naylor, M., Laud, P., Lonbard, D., Pathak, S., Guarente, L., and DePinho, R. (2004). Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat. Gen., 36, 877-882.
  172. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe M, and Guarente L. (2005). SIRT1 Shows No Substrate Specificity in Vitro. J. Biol. Chem. 280, 9780-5.
  173. Guarente, L. and Picard, F. (2005). Calorie Restriction—the SIR2 connection. Cell 120, 473-482.
  174. Bordone, L. and Guarente, L. (2005). SIRT1 and Metabolism: understanding longevity. Nature. Rev. Mol. Cell Biol. 6, 298-305.
  175. Guarente, L. (2005). Calorie restriction and SIR2 genes—Towards a mechanism. Mechanisms of aging and devel. 126, 923-928.
  176. Viswanathan, M., Kim, S., Berdichevsky, A., and Guarente, L. (2005). A role for sir-2.1 regulation of ER stress response genes in determining C. elegans lifespan. Dev. Cell 5, 605-616.
  177. Guarente, L. (2005). NO link between calorie restriction and mitochondria. Nature Chem. Biol. 1, 366-367.
  178. Bordone, L., Motta, M., Picard, F., Robinson, A., Jhala, U., Apfeld, J., McDonough, T., Lemieux, M., McBurney, M., Ealson, E., Lin, S., and Guarente, L. (2005). Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biology 4, 210-220 (published online Dec 2005).
  179. Chen, D., Steele, A., Lindquist, S., and Guarente, L. (2005). Increase in activity during calorie restriction requires Sirt1. Science, 310, 1641.
  180. Liszt, G., Ford, E., Kurtev, M., and Guarente, L. (2005). Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J. Biol. Chem. 280, 21313-21320.
  181. Mostoslavsky, R., Chua, K., Lombard, D., Pang, W., Fischer, M., Gellon, L., Liu, P., Mostoslavsky, G. Franco, S., Murphy, M., Mills, K., patel, P., Hsu, J., Hong, A., Ford, E., Cheng, H., Kennedy, K., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hursting, S., Barrett, J., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G., andf Alt, F. (2006). Genome instability and aging-like phenotype in the absence of mammalian Sirt6. Cell 124, 315-330.
  182. Berdichevsky, A., Viswanathan, M., Horvitz, R., and Guarente, L. (2006). C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend lifespan. Cell, 16, 1165-1178.
  183. Haigis, M., Mostoslavsky, R., Haigis, K., Christodolou, D., Murphy, A., Valenzuala, D., Yancopoulos, G., Karow, M., Blander, G., Weindruch, R., Alt, F., and Guarente, L. (2006). SIRT4 regulates glutamate dehydrogenase and insulin secretion in pancreatic beta cells. Cell 126, 941-954.
  184. Ford, E., Voit, R., Liszt, G., Grummt, I., and Guarente, L., (2006). Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20, 1075-1081.
  185. Sinclair, D., and Guarente, L. (2006). Unlocking the secrets of longevity genes. Scientific American. March 2006, pp. 48-57.
  186. Haigis, M., and Guarente, L. (2006). Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20, 2913-2921.
  187. Berdichevsky, A., and Guarente, L. (2006). A stress response pathway involving sirtuuins, 14-3-3 proteins, and forkhead. Cell cycle. E-pub.
  188. Guarente, L., (2006). Sirtuins as potential targets for metabolic syndrome. Nature, 444, 868-874.
  189. Kume, S., Haneda, M., Kanasaki, K., Sugimoto, T., Araki, S., Isshiki, K., Isono, M., Uzu, T., Guarente, L., Kashiwagi, A., and Koya, D. (2007). SIRT1 inhibits TGFb-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282, 151-158.
  190. Bishop, N., and Guarente, L., (2007). Skn-1 acts in two neurons to mediate calorie restriction-induced longevity in C. elegans. Nature 447, 545-549.
  191. Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., and Guarente, L. (2007). SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 28, 91-106.
  192. Bordone, L., Robinson, A., van Veen, E., Motta, M. C., Smith, C., Lintz, H., Marmor, S., Luo, J., deCabo, R., Gu, W., and Guarente, L. (2007). SIRT1 transgenic mice display calorie restriction -like phenotypes. Aging Cell, 6, 759-767.
  193. Chen, D. and Guarente, L. (2007) SIR2: a portential target for calorie restriction mimetics. Trends Mol Med 13, 64-71.
  194. Bishop, N. and Guarente, L. (2007). Genetic links between diet and lifespan. Nature Reviews 8, 835-844.
  195. Werner, H. et al., (2007). Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neuroscience 27, 7717-7730.
  196. Lombard et al. (2007). Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell Biol 27, 8807-8814.
  197. Westphal, C., Dipp, M., and Guarente, L. (2007). A therapeutic role for sirtuins in diseases of aging? TIBs 32, 555-560.
  198. Guarente, L. (2007). Sirtuins in aging and disease. CSH Symp. Quant. Biol. 72, 483-488.
  199. Guarente, L. (2008). Mitochondria — a nexus for aging, calorie restriction and sirtuins?. Cell 132, 171-175.
  200. Libert, S., Cohen, D., and Guarente, L. (2008). Neurogenesis directed by SIRT1. Nature Cell Biol. 10, 373-374.
  201. Blander, G., et al., (2008). SIRT1 promotes differentiation of normal kerotinocytes. Journal of Investigative Dermatology, in press.
  202. Chen, D., Bruno, J., Easlon, E., Lin, SJ., Alt, F. and Guarente, L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes & Dev. In press.
  203. Chen, D.*, Steele, A.*, Hutter, G., Bruno, J., Govindarajan, A., Easlon, E., Lin, SJ., Aguzzi, A., Lindquist, S. and Guarente, L. Calorie restriction and SIRT1 depletion delay the onset of prion disease. (invited revision in Aging Cell ).
  204. Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., deCabo, R., Fuchs, C., Hahn, W., Guarente, L., and Sinclair, D. (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE Apr. 16, 3, e2020.
  205. Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Kiravama, J., Chen, D., Brunet, A., Guarente., L, and Sassone-Corsi, P. (2008) The NAD-dependent Deacetylase SIRT1 Operates with CLOCK in Regulating Chromatin Remodeling and Circadian Control. (Cell in press)
  206. Liu, Y.*, Dentin, R*., Chen, D.*, Ravnskjaer, K., Cole, P., Olefsky, J., Yates, J., Guarente, L. and Montminy, M.  (2008)  SIRT1-modulated gluconeogenesis via deacetylation of TORC2. Nature, 456, 269-273.
  207. Nakagawa, T., Haigis, M., Lomb, D., and Guarente, L.  (2009). SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.  Cell, 137, 560-570.
  208. Guarente, L.  (2009).  Hypoxic hookup.  Science, 324, 12-13.
  209. Cohen, D, Supinski, A., Bonkowski, M. Donmez, G.,and Guarente, L  (2009).  Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.  Genes Dev, 23, 2812-2817. 
  210. Guarente, L.  (2010).  Forever Young.  Cell  140,  176-178.  
  211. Imai, S., Guarente, L. (2010).  Ten years of NAD-dependent SIR2 deacetylases: implications for metabolic diseases.  TIPS,  online April 4. 
  212. Berdichevsky, A., Guarente, L., Avirup Bose  (2010). Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.  J. Biol. Chem.  Published online April 29.
  213. Donmez, G., Wang, D., Cohen, D., and Guarente, L.  (2010).  SIRT1 suppresses beta-amyloid production by activating the alpha-secretase ADAM10.  Cell  142, 320-332.
  214. Bauer et al., Dietary Restriction: standing up for sirtuins.  (2010).  Science  329, 1012-1013.
  215. Asai,S., Zaima, N., Ikegami, K., Kahyo, T., Yao,I., Hatanaka, T., Iemura, S., Sugiyama, R., Yokozeki, T., Eishi, Y., Koike, M., Ikeda, K., Chiba, T., Yamaza, H., Shimokawa, I., Song, S-Y.,
    Matsuno, A., Mizutani, A., Sawabe, M., Chao, M., Tanaka, M., Kanaho, M., Natsume, T., Sugimura, H., Date, Y.,  McBurney, M., Guarente, L., and Setou, M.  SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kc Activity through Deacetylation of Specific Lysine Residues in Mammals (2010).  PLOS ONE 5, e11755.  Jul. 23, 2010.
  216. Donmez, G., and Guarente, L. (2010).  Aging and disease: connections to sirtuins.  Aging Cell 2, 285-290.
  217. Berdichevsky, A., Nedelcu, S., Boulias, K., Nicholas Bishop, N., Guarente, L., and Horvitz, H.
    R.  (2010).  3-Ketoacyl thiolase delays aging of C. elegans and is required for longevity mediated by sir-2.1. Proc. Nat. Acad. Sci. 44, 18927-18932.
  218. Zhang, Z., Lowry, S., Guarente, L., and Haimovich, B.  (2010).  Cellular bioenergetics and the coordinated regulation of Sirt1, AMPK, and HIF-1a, during the acute phase of systemic inflammation.  J. Biol. Chem.  Publiched online Oct. 21, 2010.
  219. Nakagawa, T., and Guarente, L.  Sirtuins at a glance.  (2011).  J. Cell Science Mar 15;124 (Pt 6):833-8.
  220. Bell, E. L., Emerling, B., Ricoult, S. and Guarente L.  (2011).  Sirt3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production.  Oncogene, Feb 28. [Epub ahead of print].
  221. Li, Y., Xu, S, Giles, A., Nakamura, K., Lee, J., Hou, X, Donmez, G., Li, J., Luo, Z, Walsh, K, Guarente, L., and Zang, M.  (2011).  Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.  FASEB J.  Feb. 14 (Epub ahead of print)
  222. Guarente, L.  (2011).  Sirtuins, Aging, and Medicine.   New England Journal of Medicine, 364, 2235-2244.
  223. Bell, E. and Guarente, L.  (2011).  The SIRT3 Divining rod points to oxidative damage.  Mol. Cell, 42, 511-520.
  224. Guarente L. (2011). Connecting the dots: linking sirtuins and AMPK in metabolism and aging. Dev Cell. Apr 19; 20(4):e1.
  225.  Guarente, L. (2011).  The logic that links protein acetylation and metabolism.  Cell Metab. 14, 151-153.
  226. Hasegawa, K.,Wakino, S., Simic, P., Sakamak3, Y., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Kubota, E.,  Tokuyama, H., Hayashi, K., Guarente, L., and Itoh, H.,  (2011). The Protective Role of Renal Tubular Sirt1 in the Initiation of Diabetic Nephropathy 1 through the Epigenetic Regulation of Glomerular Expression of Tight-junction Protein Claudin-1. Submitted.
  227. Hyunkyung, J., Cohen, D, Cui, L., Supinski, A., Savas3, J., Mazzulli, J., Yates, J., Bordone, L., Guarente, L., and Krainc, D.  (2011).  Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1and CREB transcriptional pathway.  Nature Medicine, online Dec. 18. doi:10.1038/nm.2559.
  228. Yao, H, Chung, S, Hwang, J., Rajendrasozhan, S., Sundar, I., Dean, D. McBurney, M., Guarente,
    L., Gu,W., Mikko, R., Kinnula, V. L., and Rahman, I.  (2011).  Sirtuin 1 protects against pulmonary emphysema via FOXO3 mediated reduction of premature senescence. J Clin Invest doi:10.1172/JCI60132.
  229. Nadtochiy, S., Yao, H., McBurney, M., Gu , W., Guarente. L., Rahman, I., and Brookes, P. (2011).  SIRT1 mediated acute cardioprotection. American J Physiol. Heart and Circ.
  230. Viswanathan, M., and Guarente, L., (2011).  Regulation of C. elegans life span by sir-2.1 transgenes.  Nature, 477 doi:10.1038/nature10440.
  231. Metallo C., Gameiro, P., Bell, E., Hiller, K., Johnson, Z., Guarente, L., Kelleher, K., Vander Heiden, M., Iliopoulos, O., and Stephanopoulos, G.  (2011). Reductive metabolism by IDH1 mediates lipogenesis of human cells under hypoxia.  Nature, online Nov. 20 doi:10.1038/nature10602.
  232. Libert, S., Pointer, K., Bell, E., Das, A., Asara, J., Kapur, K, Bergmann, S., Preisig M., Otowa, T., Kendler, K., Chen, X., Hettema, J., van den Oord, E., Rubio, J., and Guarente, L. (2011).  SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.  Cell 147, 1459-1472.
  233. Guarente, L.  (2011).  Sirtuins, Aging, and Metabolism.  Cold Spring Harbor Symposium on Quantitative Biology, doi:10.1101/sqb.2011.76.010629.
  234. Chalkiadaki, A. and Guarente, L.  (2011).  Metabolic signals regulate SIRT1 expression.  EMBO Reports Sept. 23, 2011.
  235. Chalkiadaki, A. and Guarente, L.  (2011).  Sirtuins mediate mammalian metabolic responses to nutrient availability. Nature Rev. Endocrinology, published online:17January2012 |doi:10.1038/nrendo.2011.225.
  236. Donmez, G., Arun, A., Chung, C., McLean, P, Lindquist, S., and Guarente, L.  (2012).
    SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.  Journal of Neuroscience 32, 124-132.
  237. Guarente, L.  (2012).  Sirtuins and calorie restriction.  Nature Rev. Molecular Cell Biology, 13, 207.  published online: 29 February 2012; doi:10.1038/nrm3308
  238. Chalkiadaki, A. and Guarente, L.  (2012). High fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.  Cell Metabolism, published online Aug. 7, 2012.
  239. Libert, S. and Guarente, L.  (2012). Metabolic and neuropsychiatric effects of calorie restriction and sirtuins.  Ann Rev. Physiol.  In press.
  240. Libert, S., Bonkowski, M., Pointer, K., Pletcher, S. D., and Guarente, L. (2012). Deviation of innate circadian period from 24 h reduces longevity in mice.  Aging Cell,  published online July 12, 2012.
  241. Simic, P., Zainabadi, K., , Bell, E., Sykes, D., , Saez, B., Lotinun, B.,, Baron, R.,, Scadden, D., Schipani, E.,, and Guarente, L.   SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.  (2013).   EMBO Mol. Med. In press.

  242. Simic, P., Williams, EO, Bell, E., Gong, JJ, Bonkowski, M., and Guarente, L. (2013). SIRT1 suppresses the epithelial to mesenchymal transition in cancer metastasis and organ fibrosis. Cell Reports 3;1175-86 April 10 Epub.
  243. Chang, H-C., and Guarente, L., (2013). SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153, 1448-1460.
  244. Mouchiroud, L., Houtkooper, R. Moullan, N., Katsyuba, E., Ryu, D., Canto, C., Mottis, A., Jo, Y., Viswanathan, M., Schoonjans, K., Guarente, L., and Auwerx, J. (2013). The NAD+/Sirtuin pathway modulates longevity through activation of the mitochondrial UPR and FOXO signaling. Cell 154, 430-441.
  245. Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G. (2013). Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat Commun. 4:2236. doi: 10.1038/ncomms3236.
  246. Guarente L. (2013). Sirtuins and ageing--new findings. EMBO Rep.14(9):750. doi: 10.1038/embor.2013.121. Epub 2013 Aug 9.
  247. Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I. (2013). SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol. 2013 Sep 13. [Epub ahead of print].
  248. Guarente L. (2013). Introduction: sirtuins in aging and diseases. Methods Mol Biol. 1077:3-10. doi: 10.1007/978-1-62703-637-5_1.
  249. Guarente L. (2013). Calorie restriction and sirtuins revisited. Genes Dev. 27 :2072-85. doi: 10.1101/gad.227439.113.
  250. Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H. (2013). Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med. Oct 20. doi: 10.1038/nm.3363. [Epub ahead of print].
  251. Sinclair DA, Guarente L. (2013). Small-Molecule Allosteric Activators of Sirtuins. Annu Rev Pharmacol Toxicol. 2013 Oct 16. [Epub ahead of print].
  252. Li Y., Wong, K, Giles, A, Jiang, J, Lee, JW, Adams, AC, Kharitonenkov, A, Yang, Q, Gao,B, Guarente, L, Zang, M. (2013). Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology in press.
  253. Herskovits AZ, Guarente L. (2013). Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res. Jun;23(6):746-58. doi: 10.1038/cr.2013.70. Epub 2013 May 21.
  254. Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G. (2013). Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.
  255. Chang, H-C. and Guarente, L. (2013). SIRT1 and other sirtuins in metabolism. Trends Endocrin. And Metab. published online Dec. 31.
  256. Guarente, L. (2014). Between bedside and bench. Sirtuins and the Warburg effect. Nature Med. 20, 24-25.
  257. Herskovits, A. and Guarente, L. (2014). SIRT1 in neurodevelopment and brain senescence. Neuron 81, 471-483.
  258. Chalkiadaki, A., Igarashi, M., Nasamu A., Knezevic, J., and Guarente, L. (2014). Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch fibers and Ameliorates Pathophysiology in the Mouse Model of Duchenne Muscular Dystrophy. PLoS Genet. 10 e1004490. doi: 10.1371/journal.pgen.1004490. eCollection 2014 Jul.
  259. Imai, S., and Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24, 464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29
  260. Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, White FM, Sassone-Corsi P, Guarente L. (2014). SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development 141, 3495-504. doi: 10.1242/dev.110627. Epub 2014 Aug 19.
  261. Nakagawa T, Guarente L. (2014). SnapShot: sirtuins, NAD, and aging. Cell Metab. 20, 192-192.e1. doi: 10.1016/j.cmet.2014.06.001.
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  263. Chalkiadaki, A. and Guarente, L. (2015). The multi-faceted functions of sirtuins in cancer. Nature Rev. Cancer 15, 608-624.
  264. Cunha-Santos J, Duarte-Neves J, Carmona V, Guarente L, Pereira de Almeida L, Cavadas C. (2016). Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. Nat Commun. May 11;7:11445. doi: 10.1038/ncomms11445.
  265. Igarashi M1, Guarente L2. (2016). mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction. Cell. 2016 Jul 14;166(2):436-50. doi: 10.1016/j.cell.2016.05.044. Epub 2016 Jun 23.
  266. Guarente, L. (2016). The resurgence of NAD⁺. Science. Jun 17;352(6292):1396-7. doi: 10.1126/science.aag1718.
  267. Gage FH, Guarente LP, Wagers AJ. (2016). Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. Aug;22(8):633-4. doi: 10.1016/j.molmed.2016.06.011. Epub 2016 Jul 5.
  268. Igarashi M, Guarente L. (2016). The unexpected role of mTORC1 in intestinal stem cells during calorie restriction. Cell Cycle Aug 11:1-2. [Epub ahead of print].
  269. Guarente L. (2016). Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis. Cell Metab, 24, 527-528.
  270. Williams EO, Taylor AK1, Bell EL, Lim R1, Kim DM, Guarente L (2016). Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. Cell Rep. Oct 11;17(3):809-820. doi: 10.1016/j.celrep.2016.09.046.
  271. Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L (2017). Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. Cell Rep. 18, 2310-2319. doi: 10.1016/j.celrep.2017.02.031.
  272. Glorioso C, Pfenning AR, Bennett DA, Sibille E, Kellis M, Guarente L (2017). Molecular brain aging and APOEε4 are independent and additive risk for Alzheimer’s disease. In review.
  273. Igarashi M, Guarente L. (2017). NAD+ supplementation rejuvenates aged gut adult stem cells via the SIRT1/mTORC1 axis. In review.