U.S.-Canada Winter School on Biomolecular Solid State NMR
Stowe, Vermont, January 20-25, 2008
Organized by Robert Tycko (NIH) and Robert G. Griffin (MIT)

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Recent updates:

  • June 13 2008 - updates of Rob Tycko's Mon lecture notes and problem sets (see below)

Program & Lecture notes

The final program is available in PDF format. Lecture notes for each seminar are available as PDF files (see below), and various problem sets and their solutions are available further down.

Monday lectures
1. Robert Tycko (National Institutes of Health) Basics of solid state NMR theory*
2. Chris Jaroniec (Ohio State University) Heteronuclear decoupling and recoupling
3. Kurt Zilm (Yale University) Theoretical and practical aspects of SSNMR
4. Stan Opella (Univ. of California, San Diego) Techniques for oriented systems - part I
Tuesday lectures
1. Mei Hong (Iowa State University) Theory & techniques for studying molecular  dynamics
2. Robert Griffin (Massachusetts Institute of Technology) Dynamic nuclear polarization
3. Chad Rienstra (University of Illinois) Chemical shift anisotropy and multidimensional recoupling
4. Michèle Auger (Laval University) NMR of lipids and membrane-bound systems*
Wednesday lectures
1. Ann McDermott (Columbia University) Consequences of intermediate exchange
2. Tatyana Polenova (University of Delaware) SSNMR of metal sites in biological systems*
3. Mikhail Veshtort (Massachusetts Institute of Technology) Simulation of NMR experiments with SPINEVOLUTION*
4. Yoshitaka Ishii (University of Illinois, Chicago Circle) SSNMR of paramagnetic systems
Thursday lectures
1. Tim Cross (Florida State University) From PISA wheels to high resolution protein structure
2.a Mei Hong (Iowa State University) Adv. topics - Spin diffusion for distance measurements
2.b Chad Rienstra (University of Illinois) Adv. Topics - Practical aspects of protein SSNMR
3.a Chris Jaroniec (Ohio State University) Adv. Topics - Distance restraints fro spin labeled proteins
3.b Yoshitaka Ishii (University of Illinois, Chicago Circle) Adv. Topics - Paramagnetic systems
Friday lectures
1.a Robert Tycko (National Institutes of Health) Adv. Topics - Selected topics in MAS SSNMR
1.b Ann McDermott (Columbia University) Adv. Topics
1.c Gaël De Paëpe (Massachusetts Institute of Technology) Adv. Topics - Advances in high field recoupling
2.a Tim Cross (Florida State University) Adv. Topics - Membrane proteins
2.b Stan Opella (Univ. of California, San Diego) Adv. Topics - Selected topics in oriented SSNMR
* updated since the winter school

Workshops & Problem Sets

Robert Tycko Problem set - recoupling exercises*
 
Mei Hong Problem set - dynamics Solutions
Ann McDermott Homework  
Tatyana Polenova Problem set - Metals
Workshop on ab initio calculations of NMR parameters*
 
Mikhail Veshtort Problem set - SPINEVOLUTION (pdf)* Solutions*
Yoshitaka Ishii Problem set - paramagnetic systems  
* updated since the winter school

SPINEVOLUTION workshop - software

The winter school included a workshop on SPINEVOLUTION, a software package for NMR simulations. Note that the latest version (v. 3.3.2) has been released, at the URL below. Please make sure to have this version installed! The software can be downloaded from the following website: http://web.mit.edu/fbml/cmr/griffin-group/SPINEVOLUTION/index.htm. It can also be helpful to have some variant of plotting/visualization software installed. Grace and MATLAB are recommended. To install Grace: on Mac OSX -- download the binary from http://hpc.sourceforge.net/; on Windows -- install via cygwin (http://www.cygwin.com); on Linux -- compile from the source (http://plasma-gate.weizmann.ac.il/Grace) or install binary package grace or xmgrace for your distribution of choice.

Workshop on ab initio calculations - software

There is a piece of freeware that could be useful for viewing the Gaussian input and output files, called Molden. It is available for a variety of platforms. For instructions on downloading and installing it, see: http://www.cmbi.ru.nl/molden/howtoget.html

Additional files and resources

Last updated on Feb. 16, 2008; Webpage comments