C O N S O R T I U M F O R F U N C T I O N A L G L Y C O M I C S

Search

You are being redirected to the new location for the Consortium's Web Site at http://www.functionalglycomics.org.. Please update your bookmarks based on the new site. Click on the link if you are not redirected automatically.

Mouse Phenotype Core (G)

Mouse Line Phenotype Analysis Results and Timeline

Overview

This Core is determining the phenotype of mouse strains produced by the Mouse Transgenics Core (F) and of certain existing strains contributed by Participating Investigators. Mice strains are selected by the Steering Committee for their relevance to the Consortium. Standard tests and assays are conducted by four Sub-Cores in the areas of hematology, histology, metabolism, behavior and immune function. The assays include basic behavior, neural function, muscular function, and histologic assessment of organ structure, as well as function of the liver, heart, lung, vasculature, kidneys, and blood cell production, coagulation and homeostasis. The development and function of the innate and acquired immune systems are also studied. Data are being deposited in the Central Database. These studies are providing essential information for pursuing the program’s Specific Aims toward defining the functions of glycan-binding proteins (GBPs), glycosyltransferases (GTs), and GBP-ligand relationships.

Specific Objectives

Phenotype mice bearing altered GBP and GT genes
Breed and supply mice for the Immunology and Metabolism/Behavior Sub-Cores
Prepare phenotypic data profiles for transfer to the Information and Bioinformatics Core (B)

Core G Team

Jamey Marth and Sally Orr, Coordinators

Sally Orr, Director of Immunology Sub-Core

Tricia Deane, Immunology Sub-Core Technician

Samantha Kaufman, Mouse Wrangler

Jeffrey Long, Director of Metabolism/Behavior Sub-Core

Alana Lozada, Metabolism/Behavior Sub-Core Technician

Nissi Varki, Director of Histology Sub-Core

Lucie Kim, Histology Sub-Core Technician

Dzung Le, Director of Hematology/Coagulation Sub-Core

David Ditto, Hematology/Coagulation Sub-Core Technician

Last Updated Wednesday, 01-Oct-2003 18:07:01 EDT. Please contact us with comments/questions.

This website is best viewed with Internet Explorer 5.0+ or Netscape 6.0+