Princeton University               Biophysics Seminar            May 10, 2010

Thymic Selection of T-cell Receptors

as an Extreme Value Problem

T-cell & APC

Abhishek Jha, Eric Huseby, Eugene Shakhnovich

Mehran Kardar (MIT)

Andrej Kosmrlj, Arup K. Chakraborty


I.       Introduction: T-cells, receptors, thymic selection                                       

II.      Model: Binding energy, selection, extreme values, statistical physics                                    

III.     Results: Amino-acid composition of TCRs, specificity in transgenic mice         

IV.     Analysis: Exterme Value Distribution, exact results         

V.      Summary:

  Elite controllers of HIV virus:

A. Košmrlj, ..., A.K. Chakraborty, Nature online (5 May 2010)

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