Sharp Lab
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Paul

Paul Boutz
Position:
Fellow
Research: Paul is interested in understanding the mechanisms by which double-stranded RNA molecules enter into mammalian cells. He is also collaborating with Mohini Jangi to continue work done by Cathie Garnis in conjuction with the Broad Institute to identify factors involved in CD44 alternative splicing using an RNAi-based screen.
Education: PhD, UCLA

Andrew

Andrew Bosson
Position:
Graduate Student
Research: Andrew is following up on work by current lab members, Amanda and Anthony, related to new insights into miRNA-dependent and –independent gene regulation by the Argonaute protein family and other RNA binding proteins.
Education: BA, University of Georgia

Sidi Chen

Sidi Chen
Position:
Fellow
Research: Sidi is interested in gene regulation and phenotypic roles of small RNAs. In particular, Sidi is studying microRNA functions in the stress response in the context of cellular physiology and cancer pathogenesis. Sidi is also interested in tumor evolution and development of novel targeted therapy.
Education:
PhD, University of Chicago

Anthony

Anthony Chiu
Position:
Graduate Student
Research: Anthony is interested in understanding noncoding transcription events in our genome. In particular, he is interested in exploring both the mechanisms and functions of divergent transcripts. In addition, he is interested in exploring the phenomenon of enhancer RNAs.
Education: BSc, University of Toronto

Sara

Sara Dubbury
Position:
Graduate Student

Salil Garg
Position:
Fellow
Research: Salil plans to investigate the roles small RNAs play in conferring robustness to embryonic stem cell differentiation. He is also working with postdoctoral fellow Allan Gurtan characterizing oncofetal proteins expressed early in development.
Education: MD, PhD, Harvard-M.I.T. Combined MD-PhD Program

Mohini

Mohini Jangi
Position:
Graduate Student
Research: Mohini has been working with Cathie Garnis, who established an RNAi screen in collaboration with the Broad Institute to study alternative splicing of the cell-surface glycoprotein CD44. From the data gathered in this screen, Mohini plans to explore signaling pathways involved in alternative splicing.
Education: BS, Brandeis University

Courtney

Courtney JnBaptiste
Position:
Graduate Student
Research:
Courtney is interested in understanding regulatory networks involving miRNAs and how they function to enforce specific cell states, particularly the somatic state. He is also interested in exploring the potential tumorigenicity of various miRNA families.
Education: BS, Bethune Cookman University

Tim

Tim Kelly
Position: Fellow
Research: Tim has been working on further defining the function of the Argonaut proteins in normal and diseased cellular physiology.
Education: PhD, Johns Hopkins University School of Medicine

Mary Mary Lindstrom
Position:
Lab Manager
Education: MS, Emory University
Margarita pic

Margarita Siafaca
Position:
Administrative Lab Manager, Office

Kevin Thai

Kevin Thai
Position:
Graduate Student
Research: Kevin is interested in studying the role of Argonaute proteins in tumor progression. More specifically, he plans to perform in vivo screens to identify miRNA families associated with cancer invasion and metastasis to provide insights into miRNA-based therapeutics against metastatic tumors.
Education: BS, UCSD

Xuebing Xuebing Wu
Position:
Graduate Student
Research: Xuebing is developing experimental approaches to map RNA-RNA interactions in living cells. He is also investigating the role of chromatin structure in the regulation of alternative splicing.
Education: MS, Tsinghua University
Jesse

Jesse Zamudio
Position:
Fellow
Research: Jesse is investigating the regulation of RNA polymerase II divergent transcription and exploring a functional role for transcription start site associated RNAs (TSSAs) found by former postdoc fellow Amy White.  He is also interested in the role of other noncoding RNAs in transcriptional regulation.
Education: PhD, UCLA

Lyndon Zhang Lyndon Zhang
Position:
Graduate Student
Research: Lyndon is interested in understanding the biological functions of long non-coding RNAs, in particular those of enhancer RNAs. In addition, he is interested in mapping the three-dimensional interactions of cis-regulatory elements in mammalian genomes, including super-enhancers, in order to further characterize their roles in transcriptional regulation.
 


   
   

 

 

 

 

 

 

 

 

 

 

MIT Koch Institute for Integrative Cancer Research at MIT