Decoding Cortical Organoid Networks with Multimodal Neural Interfaces

23rd April 2026

Timing : 1 pm ET

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For a list of all talks at the NanoBio seminar series Spring'26, see here

Cortical organoids have emerged as a transformative platform in modern neuroscience, offering an unparalleled model of human cortical development that 2D cultures and animal models cannot provide. Yet, the tools to rigorously interrogate organoids network dynamics lag behind the biology. We present custom transparent and flexible microelectrode arrays that enable simultaneous electrophysiological recording and imaging, purpose-built for organoid research both in vitro and in vivo. Using this platform, we reveal how spontaneous and stimulated networks evolve in organoids, and how implanted neural tissue functionally integrates with host circuitry, opening new frontiers in neural prosthetics, personalized medicine, and biological computing.

Madison Wilson
Madison Wilson is a senior Ph.D. student in Professor Duygu Kuzum’s Neuroelectronics Lab at UC San Diego. The lab focuses on creating transparent neural interfaces for spatiotemporal investigation of brain circuitry and advancing neuromorphic computing using emerging non-volatile memory technologies. Madison’s research centers on cortical organoids, bridging high-resolution electrophysiology and imaging to untangle how neural circuits form and function, from in the dish to the brain. She is a recipient of the NSF Graduate Research Fellowship (2021), Siebel Scholarship for academic excellence and leadership achievement (2023), and Hypatia Fellowship for thesis research with significant technical impact (2023).