Motor control mechanisms toward precise kinematic coding and cross-individual uniformity
26th September 2024
Timing : 11 am EST
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For a list of all talks at the NanoBio seminar Series Fall'24, see here
In this talk, we present our recent findings on how the cerebellum utilizes frequency coding to govern the detailed kinematics of movement. We demonstrate that failures in this frequency control can result in tremors or ataxia, proposing a unifying theory for a range of movement disorders. Additionally, we explore how cerebellar neurons compute precise frequency dynamics through population coding, contributing to the broader understanding of motor control across individuals.
Dr. Ming-Kai Pan, MD, PhD
Associate Professor
Department and Graduate institute of Pharmacology, College of Medicine, National Taiwan University
Cerebellar Research Center, National Taiwan University Hospital
Molecular Imaging Center, National Taiwan University
Institute of Biomedical Sciences, Academia Sinica
Ming-Kai Pan is a movement disorder specialist with a dual focus on cerebellar motor and cognitive control and their related disorders. He is currently running the Cerebellar Research Center at National Taiwan University Hospital, the deputy director of the Molecular Imaging Center at National Taiwan University, and leads several national neuroscience projects. Dr. Pan's work has significantly advanced our understanding of the pathophysiology of essential tremor, the most common movement disorder, and he has contributed to multiple textbooks as an authoritative voice on this subject. In his lab, Dr. Pan drives innovation by employing cutting-edge neural dynamic technologies, bridging clinical neurology with basic neuroscience. His expertise spans cerebellar electroencephalography with dynamic spatial mapping, intraoperative cerebellar recordings, and advanced mouse-based methodologies, including tissue clearing, optogenetics, fiber photometry, calcium imaging, optical coherence tomography, and electrophysiology. Additionally, he has made significant contributions to bioengineering, particularly in the development of novel motion-tracking technologies and volumetric super-speed microscopy. Dr. Pan's research has been published in leading journals, including Science Translational Medicine, Journal of Clinical Investigation, Bioengineering & Translational Medicine, Science Advances, Advanced Science, PNAS, and Acta Neuropathologica, reflecting his impact on both medical and neural dynamic advancements.
Associate Professor
Department and Graduate institute of Pharmacology, College of Medicine, National Taiwan University
Cerebellar Research Center, National Taiwan University Hospital
Molecular Imaging Center, National Taiwan University
Institute of Biomedical Sciences, Academia Sinica
Ming-Kai Pan is a movement disorder specialist with a dual focus on cerebellar motor and cognitive control and their related disorders. He is currently running the Cerebellar Research Center at National Taiwan University Hospital, the deputy director of the Molecular Imaging Center at National Taiwan University, and leads several national neuroscience projects. Dr. Pan's work has significantly advanced our understanding of the pathophysiology of essential tremor, the most common movement disorder, and he has contributed to multiple textbooks as an authoritative voice on this subject. In his lab, Dr. Pan drives innovation by employing cutting-edge neural dynamic technologies, bridging clinical neurology with basic neuroscience. His expertise spans cerebellar electroencephalography with dynamic spatial mapping, intraoperative cerebellar recordings, and advanced mouse-based methodologies, including tissue clearing, optogenetics, fiber photometry, calcium imaging, optical coherence tomography, and electrophysiology. Additionally, he has made significant contributions to bioengineering, particularly in the development of novel motion-tracking technologies and volumetric super-speed microscopy. Dr. Pan's research has been published in leading journals, including Science Translational Medicine, Journal of Clinical Investigation, Bioengineering & Translational Medicine, Science Advances, Advanced Science, PNAS, and Acta Neuropathologica, reflecting his impact on both medical and neural dynamic advancements.