Fibroblast growth factor 21: a therapeutic target and diagnostic biomarker for early diagnosis of metabolic syndrome linked with neurodegenerative disorder

7th September 2022

Timing : 1 pm EST

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In our earlier studies, we have established the link between metabolic syndrome (MetS) and neurodegenerative conditions, for which one of the major reasons might be the brain insulin resistance development (IR). Alzheimer's disease (AD) is a progressive neurodegenerative disorders without effective clinical cure. Exploring novel molecular targets and early diagnosis of these neurodegenartive disorders is an unmet needs clinically for effective management. Chronic stress during IR may influence the expression and release of Fibroblast growth factor 21 (FGF21), an endogenous hormone, known for its role to regulate glucose and energy metabolism in the body. Additionally, it has been discovered that diabetic and obese patients have an increased serum FGF21 levels during progression of MetS, which may be due to resistance development and or compensatory response to its receptor.



Snow
Dr. Rajeev Taliyan
Associate Professor, Department of Pharmacy,
Birla Institute of Technology and Science (BITS), Pilani, India

Prof. Taliyan has > 15 years of research experience in the field of preclinical ,Neuropharmacology, epigentics, genomic and drug toxicity studies. Prof. Taliyan published numerous research papers in National and International Journals of high repute including- (Pharmacological research-IF=7.83: Aging Res Reviews=IF-11.79:, J Controlled Release, IF- 11.47: Biomed & Pharmacother –IF 6.52: Neuropharmacology-IF= 5.52], besides attending and presenting scientific papers in many national and international conferences and seminars. He delivered invited talk in several national and international conference. He is also an Ex- executive member of Indian Pharmacological Society (IPS) and actively involved in regional conference of IPS. He is an active Professional Member of several national and international societies of high repute i.e :British Pharmacological Society*, U.K, International Union of Basic and Clinical Pharmacology, Life member of Indian Pharmacological Society, Life member of APTI, India , Life member of Indian Academy of Neurosciences and American Society for Pharmacology and Experimental Therapeutics (ASPET). Several awards are also in his credits like University Immersion award by BITS, Pilani ,to share, Improve and carry out research at Taipei medical University, Taiwan, from May 17– July 18, 2018.