Bioelectronic chronotherapy: Towards sleep and circadian rhythm-aware brain implants
12th October 2023
Timing : 1 pm EST
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For a list of all talks at the NanoBio seminar Series Fall'23, see here
Prof. Tim Denison
Royal Academy of Engineering Chair in Emerging Technologies
MRC Investigator
Depts of Engineering Science and Clinical Neuroscience
University of Oxford
Professor Denison holds a joint appointment in Engineering Science and Clinical Neurosciences at Oxford, where he explores the fundamentals of physiologic closed-loop systems. Prior to that, Tim was a Technical Fellow at Medtronic PLC and Vice President of Research & Core Technology for the Restorative Therapies Group, where he helped oversee the design of next generation neural interface and algorithm technologies for the treatment of chronic neurological disease.
In 2012, he was awarded membership to the Bakken Society, Medtronic’s highest technical and scientific honor, and in 2014 he was awarded the Wallin leadership award, becoming only the second person in Medtronic history to receive both awards. In 2015, he was elected to the College of Fellows for the American Institute of Medical and Biological Engineering (AIMBE).
Tim received an A.B. in Physics from The University of Chicago, and an M.S. and Ph.D. in Electrical Engineering from MIT. He recently completed his MBA and was named a Wallman Scholar at The University of Chicago.
Royal Academy of Engineering Chair in Emerging Technologies
MRC Investigator
Depts of Engineering Science and Clinical Neuroscience
University of Oxford
Professor Denison holds a joint appointment in Engineering Science and Clinical Neurosciences at Oxford, where he explores the fundamentals of physiologic closed-loop systems. Prior to that, Tim was a Technical Fellow at Medtronic PLC and Vice President of Research & Core Technology for the Restorative Therapies Group, where he helped oversee the design of next generation neural interface and algorithm technologies for the treatment of chronic neurological disease.
In 2012, he was awarded membership to the Bakken Society, Medtronic’s highest technical and scientific honor, and in 2014 he was awarded the Wallin leadership award, becoming only the second person in Medtronic history to receive both awards. In 2015, he was elected to the College of Fellows for the American Institute of Medical and Biological Engineering (AIMBE).
Tim received an A.B. in Physics from The University of Chicago, and an M.S. and Ph.D. in Electrical Engineering from MIT. He recently completed his MBA and was named a Wallman Scholar at The University of Chicago.
Dr. Joram van Rheede
Senior Postdoctoral Neuroengineer
University of Oxford
Dr. Joram J. van Rheede is a Senior Postdoctoral Neuroengineer in the Bioelectronics lab in the Institute of Biomedical Engineering and the MRC Brain Network Dynamics Unit at the University of Oxford. Joram obtained a BA in Liberal Arts and Sciences from Utrecht University in 2007, and moved to the University of Oxford to start the Wellcome Trust MSc + DPhil programme in Neuroscience in 2008. He obtained his MSc in Neuroscience in 2009 and defended his doctoral thesis on the role of neural activity in visual system development in 2013. After postdoctoral projects on sensory prosthetic technology and neural sensory processing, Joram joined the MRC Brain Network Dynamics Unit to work with Prof. Andrew Sharott in 2020 and joined the Bioelectronics lab to work with Prof. Tim Denison in 2023.
Key Research Areas:
Characterising the interaction of sleep/wake cycles and circadian rhythms with biomarkers and symptoms of neurological and psychiatric conditions, using data from human patients implanted with brain stimulation devices.
The testing and refinement of closed-loop neuromodulation strategies to optimise therapy for sleep and circadian rhythms, using in silico, animal model and human clinical research.
Senior Postdoctoral Neuroengineer
University of Oxford
Dr. Joram J. van Rheede is a Senior Postdoctoral Neuroengineer in the Bioelectronics lab in the Institute of Biomedical Engineering and the MRC Brain Network Dynamics Unit at the University of Oxford. Joram obtained a BA in Liberal Arts and Sciences from Utrecht University in 2007, and moved to the University of Oxford to start the Wellcome Trust MSc + DPhil programme in Neuroscience in 2008. He obtained his MSc in Neuroscience in 2009 and defended his doctoral thesis on the role of neural activity in visual system development in 2013. After postdoctoral projects on sensory prosthetic technology and neural sensory processing, Joram joined the MRC Brain Network Dynamics Unit to work with Prof. Andrew Sharott in 2020 and joined the Bioelectronics lab to work with Prof. Tim Denison in 2023.
Key Research Areas:
Characterising the interaction of sleep/wake cycles and circadian rhythms with biomarkers and symptoms of neurological and psychiatric conditions, using data from human patients implanted with brain stimulation devices.
The testing and refinement of closed-loop neuromodulation strategies to optimise therapy for sleep and circadian rhythms, using in silico, animal model and human clinical research.