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Mouse Lines

The following mouse lines have been contributed by Participating Investigators and bred by the Mouse Transgenics Core (F) and are currently available for distribution. Two breeding pairs of homozygous null animals will be provided.

Original Publication Name Colony Code Name1 Gene Symbol2
Name of Enzyme or Protein
b1,4GalT1 BT3 B4galt1 UDP-Gal:bGlcNAcb1-4galactosyltransferase, polypeptide 1
b1,4GalT1 BG4 B4galt1 UDP-Gal:bGlcNAcb1-4galactosyltransferase, polypeptide 1
C2 GlcNAcT CR Gcnt Core 2 b1-6N-acetylglucosaminyltransfersase-I
CD33/Siglec-3 CC Cd33 Sialic acid-binding Ig superfamily lectin 3
FucT-IV FA Fut4 a1-3fucosyltransferase-IV
FucT-IV and FucT-VII FC Fut4 and Fut7 a1-3fucosyltransferase-IV and a1-3fucosyltransferase-VII (double null)
FucT-VII FB Fut7 a1-3fucosyltransferase-VII
FUT1 FD Fut1 a1-2fucosyltransferase-I
FUT2 FE Fut2 a1-2fucosyltransferase-II
Gal-1 GA Lgals Galectin-1
Gal-1 and Gal-3 GN Lgals1 and Lgals3 Galectin-1 and Galectin-3 (double null)
Gal-3 GT Lgals3 Galectin-3
Gal-3 GC5 Lgals3 Galectin-3
Gal9 GJ Lgals9 Galectin-9
GalNAcT Sda blood group GW Galgt2 UDP-N-acetyl-a-D-galactosamine:(N-acetylneuraminyl)-galactosyl-N-acetylglucosaminylpolypeptide-b1-4N-acetylgalactosaminyltransferase
GM2/GD2 Synthase GM6 Galgt1 P-N-acetyl-a-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-b1-4N-acetylgalactosaminyltransferase
Mgat3 MT Mgat3 Mannoside acetyl glucosaminyltransferase 3
Mgat5 MG7 Mgat5 b1-6N-acetylglucosaminyltransferase-V
mMGL MM Mgl1 Macrophage galactose- and N-acetylgalactosamine-specific C-type lectin
mSiglec-2 (CD22) CD Cd22 CD22 antigen
mSiglec-4 (MAG) SL Mag Myelin-associated glycoprotein
PSGL-1 PS Selpl Selectin, platelet (p-selectin) ligand
ST3Gal-I ST St3gal1-pending (Siat4a) b-galactosidase a2-3sialyltransferase
ST3Gal-II SP St3gal2-pending (Siat5) Sialyltransferase 5
ST3Gal-IV SU St3gal4-pending (Siat4c) b-galactosidase a2-3sialyltransferase
ST6Gal-I SG St6gal1-pending (Siat1) N-acetyllacosaminide a2-6sialyltransferase
(GD3 Synthase)
SA St8sia1-pending (Siat8a) Sialyltransferase 8 (a2-8sialyltransferase) A

1 CFG internal mouse line identifier, specific and unique for each construct, background and type of mutation

2 As per the Mouse Genomic Nomenclature Committee (MGNC) maintained by Mouse Genome Informatics (MGI) of The Jackson Laboratory

3 Total gene ablation, homozygous neonatal lethal

4 First ATG mutated, only long message ablated

5 A second, independent line of Galectin-3 mutant mice

6 Only heterozygous males and homozygous females are currently available

7 Only heterozygous mice are currently available

Timeline for Generating Mouse Lines

Expected Mouse Lines

More Information

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Last Updated Tuesday, 28-Sep-2004 14:05:11 EDT . Please contact us with comments/questions.

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