Mouse Transgenics Core (F)

Available Mouse Lines

Specific Objectives

• Generate new knockout and knockin mice to ablate or alter the functions of selected GBP and glycosyltransferase genes
• Acquire and maintain existing knockout or transgenic strains of interest to the program
• Implement 'speed genomics' for accelerated backcrossing of the genetic trait into a fixed genetic background (C57BL/6)
• Direct and monitor breeding of mouse strains by The Scripps Research Institute custom breeding program
• Supply mice to the Mouse Phenotype Core (G) for phenotypic analysis
• Prepare mRNA from mouse tissues for the Gene Micorarray Core (E)
• Distribute mice to Participating Investigators at the direction of the Steering Committee